DE60006536D1 - Antiproliferative imidazol wirkstoffe - Google Patents

Antiproliferative imidazol wirkstoffe

Info

Publication number
DE60006536D1
DE60006536D1 DE60006536T DE60006536T DE60006536D1 DE 60006536 D1 DE60006536 D1 DE 60006536D1 DE 60006536 T DE60006536 T DE 60006536T DE 60006536 T DE60006536 T DE 60006536T DE 60006536 D1 DE60006536 D1 DE 60006536D1
Authority
DE
Germany
Prior art keywords
antiproliferative
active substances
compounds
imidazole active
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60006536T
Other languages
English (en)
Other versions
DE60006536T2 (de
Inventor
Le Wang
Qun Li
Hing L Sham
W Woods
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE60006536D1 publication Critical patent/DE60006536D1/de
Application granted granted Critical
Publication of DE60006536T2 publication Critical patent/DE60006536T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE60006536T 1999-08-02 2000-07-21 Antiproliferative imidazol wirkstoffe Expired - Fee Related DE60006536T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US365936 1999-08-02
US09/365,936 US6201001B1 (en) 1999-08-02 1999-08-02 Imidazole antiproliferative agents
PCT/US2000/020053 WO2001009103A2 (en) 1999-08-02 2000-07-21 Imidazole antiproliferative agents

Publications (2)

Publication Number Publication Date
DE60006536D1 true DE60006536D1 (de) 2003-12-18
DE60006536T2 DE60006536T2 (de) 2004-09-23

Family

ID=23441008

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60006536T Expired - Fee Related DE60006536T2 (de) 1999-08-02 2000-07-21 Antiproliferative imidazol wirkstoffe

Country Status (11)

Country Link
US (1) US6201001B1 (de)
EP (1) EP1200412B1 (de)
JP (1) JP2003527318A (de)
AT (1) ATE254110T1 (de)
CA (1) CA2378942A1 (de)
DE (1) DE60006536T2 (de)
DK (1) DK1200412T3 (de)
ES (1) ES2212778T3 (de)
MX (1) MXPA02001213A (de)
PT (1) PT1200412E (de)
WO (1) WO2001009103A2 (de)

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US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US20020143284A1 (en) * 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US20040111050A1 (en) * 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US6638239B1 (en) * 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7431710B2 (en) * 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
EP1418868B1 (de) * 2001-04-07 2008-03-26 Glaukos Corporation Glaukom-stent für die glaukom-behandlung
US7678065B2 (en) * 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US7094225B2 (en) * 2001-05-03 2006-08-22 Glaukos Corporation Medical device and methods of use of glaucoma treatment
US20040229960A1 (en) * 2001-07-13 2004-11-18 David Sherris Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US7163543B2 (en) * 2001-11-08 2007-01-16 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US7632955B2 (en) 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US7528165B2 (en) 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
TWI317634B (en) 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20060148674A1 (en) * 2004-12-31 2006-07-06 Luduena Richard F Therapeutic composition
US7456289B2 (en) 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
WO2007139808A2 (en) * 2006-05-25 2007-12-06 Ayyala Ramesh S Device for delivery of antifibrotic agents & method
CA2668954C (en) 2006-11-10 2020-09-08 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20090192098A1 (en) 2007-11-21 2009-07-30 Oxigene, Inc. Method for treating hematopoietic neoplasms
WO2009096853A1 (en) * 2008-01-28 2009-08-06 Milux Holding Sa Blood clot removal device, system, and method
CN101602730B (zh) * 2008-06-12 2013-06-19 北大方正集团有限公司 取代的咪唑衍生物
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CN102190625B (zh) * 2010-03-18 2013-08-28 南京圣和药业有限公司 二苯乙烯类肿瘤靶向药物Combretastatin A4类似物
US8980933B2 (en) 2010-05-05 2015-03-17 Universitat Bayreuth Combretastatin analogs for use in the treatment of cancer
CN102863388B (zh) * 2011-07-05 2015-04-29 南京圣和药业股份有限公司 肿瘤靶向药物Combretastatin A4衍生物
CN105753787B (zh) * 2011-07-05 2018-05-15 南京圣和药业股份有限公司 肿瘤靶向药物Combretastatin A4衍生物
WO2013040079A1 (en) 2011-09-13 2013-03-21 Dose Medical Corporation Intraocular physiological sensor
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
AU2014228822A1 (en) 2013-03-15 2015-10-01 Memorial Sloan-Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
CN104771396B (zh) * 2014-01-14 2019-04-26 南京圣和药业股份有限公司 4-(3,5-二甲氧苯基)-5-(3-羟基-4-甲氧基苯基)咪唑的应用
JP2018523712A (ja) 2015-08-18 2018-08-23 マテオン セラピューティクス, インク.Mateon Therapeutics, Inc. 腫瘍に対する免疫調節療法を向上させる為のｖｄａｓの使用
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof

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JPS6481673A (en) * 1987-09-22 1989-03-27 Takashi Yamada Automatic generator
US5296609A (en) * 1993-04-09 1994-03-22 Syntex Pharmaceuticals, Ltd. Process for the preparation of 1,2,4-substituted imidazoles and related aminoalkylimidazole derivatives
JPH1081673A (ja) 1996-09-06 1998-03-31 Ajinomoto Co Inc 複素環誘導体、及びそれを含有する制癌剤
US5886025A (en) * 1997-03-06 1999-03-23 Baylor University Anti-mitotic agents which inhibit tubulin polymerization

Also Published As

Publication number Publication date
ES2212778T3 (es) 2004-08-01
MXPA02001213A (es) 2002-07-30
EP1200412B1 (de) 2003-11-12
CA2378942A1 (en) 2001-02-08
DE60006536T2 (de) 2004-09-23
US6201001B1 (en) 2001-03-13
PT1200412E (pt) 2004-04-30
DK1200412T3 (da) 2004-03-22
JP2003527318A (ja) 2003-09-16
WO2001009103A2 (en) 2001-02-08
ATE254110T1 (de) 2003-11-15
WO2001009103A3 (en) 2001-05-31
EP1200412A2 (de) 2002-05-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee