RU95108590A - Производные имидазола - Google Patents
Производные имидазолаInfo
- Publication number
- RU95108590A RU95108590A RU95108590/04A RU95108590A RU95108590A RU 95108590 A RU95108590 A RU 95108590A RU 95108590/04 A RU95108590/04 A RU 95108590/04A RU 95108590 A RU95108590 A RU 95108590A RU 95108590 A RU95108590 A RU 95108590A
- Authority
- RU
- Russia
- Prior art keywords
- imidazole derivatives
- imidazole
- derivatives
- new
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Coloring (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Предлагаются новые производные имидазола, являющиеся промежуточными соединениями в синтезе ценных биологически- активных лекарственных веществ.
Claims (1)
- Предлагаются новые производные имидазола, являющиеся промежуточными соединениями в синтезе ценных биологически- активных лекарственных веществ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4010797.3 | 1990-04-04 | ||
DE4010797A DE4010797A1 (de) | 1990-04-04 | 1990-04-04 | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU4894882 Division |
Publications (2)
Publication Number | Publication Date |
---|---|
RU95108590A true RU95108590A (ru) | 1997-03-20 |
RU2092482C1 RU2092482C1 (ru) | 1997-10-10 |
Family
ID=6403704
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU914894882A RU2060255C1 (ru) | 1990-04-04 | 1991-04-03 | Способ получения производных имидазола или их физиологически переносимых солей |
RU9595108590A RU2092482C1 (ru) | 1990-04-04 | 1995-05-30 | Производные имидазола |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU914894882A RU2060255C1 (ru) | 1990-04-04 | 1991-04-03 | Способ получения производных имидазола или их физиологически переносимых солей |
Country Status (25)
Country | Link |
---|---|
US (2) | US5350751A (ru) |
EP (1) | EP0450566B1 (ru) |
JP (1) | JP3212036B2 (ru) |
KR (1) | KR910018376A (ru) |
CN (2) | CN1031940C (ru) |
AT (1) | ATE124696T1 (ru) |
AU (2) | AU644857B2 (ru) |
CA (1) | CA2039622A1 (ru) |
CZ (1) | CZ280248B6 (ru) |
DE (2) | DE4010797A1 (ru) |
DK (1) | DK0450566T3 (ru) |
ES (1) | ES2076395T3 (ru) |
FI (1) | FI911584A (ru) |
HU (2) | HU213096B (ru) |
IE (1) | IE67790B1 (ru) |
IL (1) | IL97760A (ru) |
MA (1) | MA22112A1 (ru) |
MX (1) | MX25204A (ru) |
MY (1) | MY109937A (ru) |
NO (1) | NO177266C (ru) |
NZ (2) | NZ237644A (ru) |
PT (1) | PT97254B (ru) |
RU (2) | RU2060255C1 (ru) |
SK (1) | SK278797B6 (ru) |
ZA (1) | ZA912458B (ru) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
DE4023215A1 (de) * | 1990-07-21 | 1992-01-23 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung |
US5374615A (en) * | 1990-10-31 | 1994-12-20 | E. R. Squibb & Sons, Inc. | Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives |
PH31175A (en) * | 1990-10-31 | 1998-03-20 | Squibb & Sons Inc | Indole and benzimi-dazole-substituted imidazole and benzimidazole derivatives. |
DE4036706A1 (de) * | 1990-11-17 | 1992-05-21 | Hoechst Ag | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
TW197428B (ru) | 1991-01-04 | 1993-01-01 | Hoechst Ag | |
CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
GB9108811D0 (en) * | 1991-04-24 | 1991-06-12 | Erba Carlo Spa | N-imidazolyl derivatives of substituted indole |
TW215434B (ru) * | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
US5364869A (en) * | 1992-03-09 | 1994-11-15 | Abbott Laboratories | Heterocycle-substituted benzyaminopyridine angiotensin II receptor antagonists |
RU2103262C1 (ru) * | 1992-07-16 | 1998-01-27 | Лонца АГ Гампель/Валлис | Способ получения 2-замещенных 5-хлоримидазол-4-карбальдегидов |
EP0614889A1 (de) * | 1993-03-12 | 1994-09-14 | Lonza Ag | Verfahren zur Herstellung von gegebenenfalls 2-substituierten 5-Chlorimidazol-4-carbaldehyden |
US5442075A (en) * | 1993-03-12 | 1995-08-15 | Lonza Ltd. | Process for the production of 2-substituted 5-chlorimidazole-4-carbaldehydes |
US5338740A (en) * | 1993-07-13 | 1994-08-16 | Pfizer Inc. | Angiotensin II receptor antagonists |
GB9725953D0 (en) * | 1997-12-08 | 1998-02-04 | Pfizer Ltd | Compounds useful in therapy |
DE19802969A1 (de) | 1998-01-27 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
AU2002364381A1 (en) * | 2001-11-23 | 2003-06-10 | Solvay Pharmaceuticals Gmbh | Hypertonia treatment during the acute phase of a cerebrovascular accident |
ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
CA2583084C (en) | 2003-09-19 | 2010-12-07 | Galileo Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
KR20110007258A (ko) | 2006-03-22 | 2011-01-21 | 에프. 호프만-라 로슈 아게 | 11-베타-hsd-1로서의 피라졸 |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CN101772513B (zh) | 2007-06-04 | 2013-11-13 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
JP2013506624A (ja) * | 2009-09-23 | 2013-02-28 | アミラ ファーマシューティカルズ,インク. | 5−リポキシゲナーゼのインドリジンインヒビター |
US20130005721A1 (en) * | 2009-09-23 | 2013-01-03 | Panmira Pharmaceuticals, Llc | Indolizine inhibitors of 5-lipoxygenase |
BR112012010752B1 (pt) | 2009-11-05 | 2021-07-20 | University Of Notre Dame Du Lac | Compostos imidazo[1,2-a]piridina |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
CA2913737A1 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
EP3328382A4 (en) | 2015-09-17 | 2018-12-19 | Marvin J. Miller | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT44957B (de) * | 1907-12-24 | 1910-11-10 | Charles Henri Perrin | Apparat zum Filtrieren von Flüssigkeiten. |
AT53390B (de) * | 1908-10-15 | 1912-05-10 | Elek Sche Ind Ges | Kühleinrichtung für gekapselte elektrische Maschinen. |
CH443777A (de) * | 1965-08-06 | 1968-02-15 | Agripat Sa | Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens |
US4182769A (en) * | 1977-02-09 | 1980-01-08 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones |
US4698356A (en) * | 1979-08-14 | 1987-10-06 | University Of Miami | Anti-hypertensive agents |
US4690939A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
US4690940A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
US4695577A (en) * | 1979-08-14 | 1987-09-22 | University Of Miami | Anti-hypertensive agents |
US4690937A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
US4690938A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
US4698355A (en) * | 1979-08-14 | 1987-10-06 | University Of Miami | Anti-hypertensive agents |
ZA794723B (en) * | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
AU538665B2 (en) * | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
ZA81219B (en) * | 1980-01-23 | 1982-01-27 | Schering Corp | Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them |
PT70158A1 (en) * | 1980-03-03 | 1982-03-01 | Univ Miami | Process for preparing anti-hypertensive agents |
US4833152A (en) * | 1980-03-05 | 1989-05-23 | University Of Miami | Anti-hypertensive agents |
US4692458A (en) * | 1980-03-05 | 1987-09-08 | University Of Miami | Anti-hypertensive agents |
US4690936A (en) * | 1980-03-05 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
DE3161915D1 (en) * | 1980-03-05 | 1984-02-23 | Univ Miami | Angiotensin converting enzyme inhibitors |
US4734420A (en) * | 1980-03-05 | 1988-03-29 | University Of Miami | Anti-hypertensive agents |
US4352808A (en) * | 1980-12-12 | 1982-10-05 | Schering Corporation | 3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes and related derivatives, their use as antimicrobials and pharmaceutical formulations useful therefore |
US4507294A (en) * | 1982-03-08 | 1985-03-26 | Schering Corp. | Imidazo[1,2-a]pyrazines |
EP0068378B1 (en) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
US4436746A (en) * | 1982-09-30 | 1984-03-13 | Ciba-Geigy Corporation | Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles |
US4539410A (en) * | 1982-09-30 | 1985-09-03 | Ciba-Geigy Corporation | N-Substituted-2-(1-imidazolyl)indoles |
US4695578A (en) * | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
US4695579A (en) * | 1984-12-21 | 1987-09-22 | Schering Corporation | Antifungal 2-azolylmethyl-3-difluorobenzyloxy-2,3-dihydrofluoro-benzo(B) thiophens |
GB8518741D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
GB8518742D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
US4731364A (en) * | 1985-08-12 | 1988-03-15 | Schering Corporation | Dihydrobenzo(B)thiophenes and pharmaceutical compositions thereof useful as antifungals |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
AU7928787A (en) * | 1986-10-07 | 1988-04-14 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazopyridine derivatives |
EP0266890A1 (en) * | 1986-10-07 | 1988-05-11 | Yamanouchi Pharmaceutical Co. Ltd. | Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them |
GB8630759D0 (en) * | 1986-12-23 | 1987-02-04 | Janssen Pharmaceutica Nv | Carboxylic acid derivatives |
NZ224714A (en) * | 1987-06-01 | 1990-03-27 | Janssen Pharmaceutica Nv | Substituted benzotriazole derivatives and pharmaceutical compositions |
US4943574A (en) * | 1987-06-01 | 1990-07-24 | Janssen Pharmaceutica N.V. | (1H-azol-1-ylmethyl) substituted benzotriazole derivatives and pharmaceutical compositions containing them |
US4957931A (en) * | 1987-07-08 | 1990-09-18 | Ciba-Geigy Corporation | Certain 1,2-benzisoxazole and 1,2-benzisothiazole derivatives |
US4859691A (en) * | 1987-07-08 | 1989-08-22 | Ciba-Geigy Corporation | Certain 1,2-benzisoxazole derivatives |
GB8724912D0 (en) * | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
JP2614756B2 (ja) * | 1988-08-10 | 1997-05-28 | 日本ケミファ株式会社 | イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
US4977174A (en) * | 1989-06-12 | 1990-12-11 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
EP0409332A3 (en) * | 1989-07-19 | 1991-08-07 | Merck & Co. Inc. | Substituted triazoles as angiotensin ii antagonists |
US5183810A (en) * | 1990-02-13 | 1993-02-02 | Merck & Co., Inc. | Imidazole angiotensin II antagonists incorporating a substituted benzyl element |
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
DE4023215A1 (de) * | 1990-07-21 | 1992-01-23 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung |
TW215434B (ru) * | 1992-03-07 | 1993-11-01 | Hoechst Ag |
-
1990
- 1990-04-04 DE DE4010797A patent/DE4010797A1/de not_active Withdrawn
-
1991
- 1991-03-28 NZ NZ237644A patent/NZ237644A/en unknown
- 1991-03-28 NZ NZ260561A patent/NZ260561A/xx unknown
- 1991-04-02 EP EP91105178A patent/EP0450566B1/de not_active Expired - Lifetime
- 1991-04-02 ES ES91105178T patent/ES2076395T3/es not_active Expired - Lifetime
- 1991-04-02 SK SK906-91A patent/SK278797B6/sk unknown
- 1991-04-02 AT AT91105178T patent/ATE124696T1/de not_active IP Right Cessation
- 1991-04-02 DK DK91105178.7T patent/DK0450566T3/da active
- 1991-04-02 CZ CS91906A patent/CZ280248B6/cs not_active IP Right Cessation
- 1991-04-02 US US07/679,233 patent/US5350751A/en not_active Expired - Lifetime
- 1991-04-02 MY MYPI91000552A patent/MY109937A/en unknown
- 1991-04-02 DE DE59105897T patent/DE59105897D1/de not_active Expired - Lifetime
- 1991-04-02 FI FI911584A patent/FI911584A/fi unknown
- 1991-04-03 MX MX2520491A patent/MX25204A/es unknown
- 1991-04-03 ZA ZA912458A patent/ZA912458B/xx unknown
- 1991-04-03 IL IL97760A patent/IL97760A/xx not_active IP Right Cessation
- 1991-04-03 AU AU74013/91A patent/AU644857B2/en not_active Ceased
- 1991-04-03 RU SU914894882A patent/RU2060255C1/ru active
- 1991-04-03 JP JP09611991A patent/JP3212036B2/ja not_active Expired - Lifetime
- 1991-04-03 CN CN91102043A patent/CN1031940C/zh not_active Expired - Fee Related
- 1991-04-03 IE IE109891A patent/IE67790B1/en not_active IP Right Cessation
- 1991-04-03 NO NO911302A patent/NO177266C/no unknown
- 1991-04-03 CA CA002039622A patent/CA2039622A1/en not_active Abandoned
- 1991-04-04 KR KR1019910005416A patent/KR910018376A/ko active IP Right Grant
- 1991-04-04 MA MA22381A patent/MA22112A1/fr unknown
- 1991-04-04 PT PT97254A patent/PT97254B/pt not_active IP Right Cessation
- 1991-04-04 HU HU911091A patent/HU213096B/hu not_active IP Right Cessation
-
1993
- 1993-12-21 AU AU52560/93A patent/AU658781B2/en not_active Ceased
-
1994
- 1994-05-27 US US08/250,491 patent/US5440046A/en not_active Expired - Lifetime
- 1994-10-22 CN CN94117640A patent/CN1036263C/zh not_active Expired - Fee Related
-
1995
- 1995-05-30 RU RU9595108590A patent/RU2092482C1/ru active
- 1995-06-28 HU HU95P/P00507P patent/HU211464A9/hu unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU95108590A (ru) | Производные имидазола | |
HUT76511A (en) | Benzoyl derivatives, preparation and use thereot | |
RU95116357A (ru) | Производные пирролидина и тиазолидина, способы их получения, способ разделения энантиомеров и фармацевтическая композиция на основе производных пирролидина и тиазолидина | |
ES2123149T3 (es) | Derivados de perhidroisoindol como antagonistas de la substancia p. | |
EE9800080A (et) | (Metüülsulfonüül)fenüül-2-(5H)-furanoonid, nende kasutamine ja farmatseutilised kompositsioonid | |
BR8707672A (pt) | Pirazolinas inseticidas | |
ATE216590T1 (de) | Arzneimittelformulierungen für il-12 | |
DE69618820D1 (de) | 3,4-diaryl-2-hydroxy-2,5-dihydrofurane als wirkstoffvorstufen von cox-2 inhibitoren | |
TR200001012T2 (tr) | Yeni ariloksi-alkil-dialkilaminler. | |
RU94035686A (ru) | 4-ариламино-бензопиран и родственные соединения, фармацевтическая композиция, способ лечения | |
PL337499A1 (en) | Novel 2-(iminomethyl)aminophenylic derivatives, their production and application as drugs and pharmaceutic agents containing such derivatives | |
RU94036749A (ru) | Замещенные 1-нафтилпиразол-3-карбоксамиды, способ их получения, содержащие их фармацевтические композиции и промежуточные соединения синтеза | |
GR1001597B (el) | Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών. | |
FI944823A (fi) | Galantamiinijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineissa | |
RU94038042A (ru) | Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент | |
RU95107655A (ru) | Глюкопиранозидбензотиофены, способ получения, фармацевтическая композиция | |
RU94000725A (ru) | Производные 9н-имидазо (1,2-a) бензимидазол-3-ацетамида, способ их получения, фармацевтическая композиция на их основе и промежуточные соединения синтеза | |
PT1000067E (pt) | Tiazolobenzo-heterociclos sua preparacao e medicamentos que os contem | |
RU94036769A (ru) | Алкильные производные тразодона, способ их получения, промежуточные соединения и фармацевтическая композиция | |
PT1001942E (pt) | Poli-hidroxibutilpirazinas sua preparacao e medicamentos que as contem | |
MX9706283A (es) | Nuevos antibioticos de polieno, 3874 hi a h6, procedimientos para su preparacion y empleo. | |
EA200000006A1 (ru) | Новые производные пентаэритрита, их получение и применение, а также промежуточные соединения для их синтеза | |
GR3030190T3 (en) | Benzoyl derivatives and synthesis thereof | |
RU94046312A (ru) | Применение биологически активных уреидопроизводных для лечения индуцируемых лентивирусами заболеваний, продукты, содержащие уреидопроизводные | |
IT8821369A0 (it) | Composizione farmaceutica utile per il trattamento di malattie cardiovascolari. |