RU95108590A - Производные имидазола - Google Patents

Производные имидазола

Info

Publication number
RU95108590A
RU95108590A RU95108590/04A RU95108590A RU95108590A RU 95108590 A RU95108590 A RU 95108590A RU 95108590/04 A RU95108590/04 A RU 95108590/04A RU 95108590 A RU95108590 A RU 95108590A RU 95108590 A RU95108590 A RU 95108590A
Authority
RU
Russia
Prior art keywords
imidazole derivatives
imidazole
derivatives
new
synthesis
Prior art date
Application number
RU95108590/04A
Other languages
English (en)
Other versions
RU2092482C1 (ru
Inventor
Вагнер Адальберт
De]
Хеннинг Райнер
Герхардс Херманн
Шелькенс Бернхард
Original Assignee
Хехст АГ (DE)
Хехст АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст АГ (DE), Хехст АГ filed Critical Хехст АГ (DE)
Publication of RU95108590A publication Critical patent/RU95108590A/ru
Application granted granted Critical
Publication of RU2092482C1 publication Critical patent/RU2092482C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Coloring (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Предлагаются новые производные имидазола, являющиеся промежуточными соединениями в синтезе ценных биологически- активных лекарственных веществ.

Claims (1)

  1. Предлагаются новые производные имидазола, являющиеся промежуточными соединениями в синтезе ценных биологически- активных лекарственных веществ.
RU9595108590A 1990-04-04 1995-05-30 Производные имидазола RU2092482C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4010797.3 1990-04-04
DE4010797A DE4010797A1 (de) 1990-04-04 1990-04-04 Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU4894882 Division

Publications (2)

Publication Number Publication Date
RU95108590A true RU95108590A (ru) 1997-03-20
RU2092482C1 RU2092482C1 (ru) 1997-10-10

Family

ID=6403704

Family Applications (2)

Application Number Title Priority Date Filing Date
SU914894882A RU2060255C1 (ru) 1990-04-04 1991-04-03 Способ получения производных имидазола или их физиологически переносимых солей
RU9595108590A RU2092482C1 (ru) 1990-04-04 1995-05-30 Производные имидазола

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU914894882A RU2060255C1 (ru) 1990-04-04 1991-04-03 Способ получения производных имидазола или их физиологически переносимых солей

Country Status (25)

Country Link
US (2) US5350751A (ru)
EP (1) EP0450566B1 (ru)
JP (1) JP3212036B2 (ru)
KR (1) KR910018376A (ru)
CN (2) CN1031940C (ru)
AT (1) ATE124696T1 (ru)
AU (2) AU644857B2 (ru)
CA (1) CA2039622A1 (ru)
CZ (1) CZ280248B6 (ru)
DE (2) DE4010797A1 (ru)
DK (1) DK0450566T3 (ru)
ES (1) ES2076395T3 (ru)
FI (1) FI911584A (ru)
HU (2) HU213096B (ru)
IE (1) IE67790B1 (ru)
IL (1) IL97760A (ru)
MA (1) MA22112A1 (ru)
MX (1) MX25204A (ru)
MY (1) MY109937A (ru)
NO (1) NO177266C (ru)
NZ (2) NZ237644A (ru)
PT (1) PT97254B (ru)
RU (2) RU2060255C1 (ru)
SK (1) SK278797B6 (ru)
ZA (1) ZA912458B (ru)

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DE4023215A1 (de) * 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
US5374615A (en) * 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
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DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
TW197428B (ru) 1991-01-04 1993-01-01 Hoechst Ag
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
GB9108811D0 (en) * 1991-04-24 1991-06-12 Erba Carlo Spa N-imidazolyl derivatives of substituted indole
TW215434B (ru) * 1992-03-07 1993-11-01 Hoechst Ag
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US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101772513B (zh) 2007-06-04 2013-11-13 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JP2013506624A (ja) * 2009-09-23 2013-02-28 アミラ ファーマシューティカルズ，インク． ５−リポキシゲナーゼのインドリジンインヒビター
US20130005721A1 (en) * 2009-09-23 2013-01-03 Panmira Pharmaceuticals, Llc Indolizine inhibitors of 5-lipoxygenase
BR112012010752B1 (pt) 2009-11-05 2021-07-20 University Of Notre Dame Du Lac Compostos imidazo[1,2-a]piridina
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Also Published As

Publication number Publication date
NZ237644A (en) 1994-12-22
EP0450566A1 (de) 1991-10-09
CZ280248B6 (cs) 1995-12-13
CN1036263C (zh) 1997-10-29
PT97254B (pt) 1998-07-31
ZA912458B (en) 1991-12-24
MX25204A (es) 1993-08-01
RU2060255C1 (ru) 1996-05-20
SK278797B6 (sk) 1998-03-04
AU5256093A (en) 1994-02-24
AU7401391A (en) 1991-10-10
JP3212036B2 (ja) 2001-09-25
DE59105897D1 (de) 1995-08-10
EP0450566B1 (de) 1995-07-05
FI911584A (fi) 1991-10-05
ES2076395T3 (es) 1995-11-01
HU213096B (en) 1997-02-28
NO911302D0 (no) 1991-04-03
NO911302L (no) 1991-10-07
HUT60734A (en) 1992-10-28
CN1055361A (zh) 1991-10-16
CN1031940C (zh) 1996-06-05
AU658781B2 (en) 1995-04-27
MA22112A1 (fr) 1991-12-31
CA2039622A1 (en) 1991-10-05
IE911098A1 (en) 1991-10-09
HU911091D0 (en) 1991-10-28
PT97254A (pt) 1992-01-31
FI911584A0 (fi) 1991-04-02
KR910018376A (ko) 1991-11-30
NO177266B (no) 1995-05-08
IL97760A0 (en) 1992-06-21
IE67790B1 (en) 1996-04-17
ATE124696T1 (de) 1995-07-15
HU211464A9 (en) 1995-11-28
MY109937A (en) 1997-10-31
US5440046A (en) 1995-08-08
NO177266C (no) 1995-08-16
RU2092482C1 (ru) 1997-10-10
JPH04234876A (ja) 1992-08-24
DE4010797A1 (de) 1991-10-10
DK0450566T3 (da) 1995-10-30
NZ260561A (en) 1995-01-27
CS9100906A2 (en) 1991-11-12
CN1105993A (zh) 1995-08-02
US5350751A (en) 1994-09-27
IL97760A (en) 1997-06-10
AU644857B2 (en) 1993-12-23

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