ES2076395T3 - Azoles sustituidos, procedimiento para su preparacion, agentes que los contienen y su utilizacion. - Google Patents

Azoles sustituidos, procedimiento para su preparacion, agentes que los contienen y su utilizacion.

Info

Publication number
ES2076395T3
ES2076395T3 ES91105178T ES91105178T ES2076395T3 ES 2076395 T3 ES2076395 T3 ES 2076395T3 ES 91105178 T ES91105178 T ES 91105178T ES 91105178 T ES91105178 T ES 91105178T ES 2076395 T3 ES2076395 T3 ES 2076395T3
Authority
ES
Spain
Prior art keywords
preparation
azols
substituted
agents
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91105178T
Other languages
English (en)
Inventor
Adalbert Dr Wagner
Rainer Dr Henning
Hermann Dr Gerhards
Bernward Dr Scholkens
Caille Jean-Claude
Vevert Jean-Paul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2076395T3 publication Critical patent/ES2076395T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Coloring (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

LA INVENCION CONCIERNE A COMPUESTOS DE FORMULA EN LA QUE X, Y Y Z SON IGUALES O DISTINTOS Y REPRESENTAN N O CR (AL CUADRADO) ; R ELEVADO 1 Y R (AL CUADRADO) ESTAN DEFINIDOS EN LA MEMORIA; L REPRESENTA UN RESTO ALQUILENO; Q = 0 O 1 Y A REPRESENTA EL RESTO DE UN HETEROBICICLO ANILLADO. LA INVENCION CONCIERNE ADEMAS A UN PROCEDIMIENTO PARA LA OBTENCION DE DICHOS COMPUESTOS, A LOS PREPARADOS QUE LOS CONTIENEN Y A SU APLICACION.
ES91105178T 1990-04-04 1991-04-02 Azoles sustituidos, procedimiento para su preparacion, agentes que los contienen y su utilizacion. Expired - Lifetime ES2076395T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4010797A DE4010797A1 (de) 1990-04-04 1990-04-04 Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung

Publications (1)

Publication Number Publication Date
ES2076395T3 true ES2076395T3 (es) 1995-11-01

Family

ID=6403704

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91105178T Expired - Lifetime ES2076395T3 (es) 1990-04-04 1991-04-02 Azoles sustituidos, procedimiento para su preparacion, agentes que los contienen y su utilizacion.

Country Status (25)

Country Link
US (2) US5350751A (es)
EP (1) EP0450566B1 (es)
JP (1) JP3212036B2 (es)
KR (1) KR910018376A (es)
CN (2) CN1031940C (es)
AT (1) ATE124696T1 (es)
AU (2) AU644857B2 (es)
CA (1) CA2039622A1 (es)
CZ (1) CZ280248B6 (es)
DE (2) DE4010797A1 (es)
DK (1) DK0450566T3 (es)
ES (1) ES2076395T3 (es)
FI (1) FI911584A (es)
HU (2) HU213096B (es)
IE (1) IE67790B1 (es)
IL (1) IL97760A (es)
MA (1) MA22112A1 (es)
MX (1) MX25204A (es)
MY (1) MY109937A (es)
NO (1) NO177266C (es)
NZ (2) NZ260561A (es)
PT (1) PT97254B (es)
RU (2) RU2060255C1 (es)
SK (1) SK278797B6 (es)
ZA (1) ZA912458B (es)

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DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
DE4023215A1 (de) * 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
US5374615A (en) * 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
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DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
TW197428B (es) 1991-01-04 1993-01-01 Hoechst Ag
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
GB9108811D0 (en) * 1991-04-24 1991-06-12 Erba Carlo Spa N-imidazolyl derivatives of substituted indole
TW215434B (es) * 1992-03-07 1993-11-01 Hoechst Ag
US5364869A (en) * 1992-03-09 1994-11-15 Abbott Laboratories Heterocycle-substituted benzyaminopyridine angiotensin II receptor antagonists
RU2103262C1 (ru) * 1992-07-16 1998-01-27 Лонца АГ Гампель/Валлис Способ получения 2-замещенных 5-хлоримидазол-4-карбальдегидов
US5442075A (en) * 1993-03-12 1995-08-15 Lonza Ltd. Process for the production of 2-substituted 5-chlorimidazole-4-carbaldehydes
EP0614889A1 (de) * 1993-03-12 1994-09-14 Lonza Ag Verfahren zur Herstellung von gegebenenfalls 2-substituierten 5-Chlorimidazol-4-carbaldehyden
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
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SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
GB0008269D0 (en) * 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
AU2002364381A1 (en) * 2001-11-23 2003-06-10 Solvay Pharmaceuticals Gmbh Hypertonia treatment during the acute phase of a cerebrovascular accident
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US20050065099A1 (en) * 2003-09-19 2005-03-24 Gail Walkinshaw Treatment of mitochondrial diseases
WO2007107470A2 (en) 2006-03-22 2007-09-27 F. Hoffmann-La Roche Ag Pyrazoles as 11-beta-hsd-1
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US20130005721A1 (en) * 2009-09-23 2013-01-03 Panmira Pharmaceuticals, Llc Indolizine inhibitors of 5-lipoxygenase
WO2011038097A2 (en) * 2009-09-23 2011-03-31 Amira Pharmaceuticals, Inc. Indolizine inhibitors of 5-lipoxygenase
CN106866667B (zh) 2009-11-05 2019-11-15 圣母大学 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
KR20180053386A (ko) 2015-09-17 2018-05-21 마빈 제이. 밀러 마이코박테리아 감염에 대해 유용한 벤질 아민-함유 헤테로사이클릭 화합물 및 조성물
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Also Published As

Publication number Publication date
IE67790B1 (en) 1996-04-17
CA2039622A1 (en) 1991-10-05
AU658781B2 (en) 1995-04-27
EP0450566B1 (de) 1995-07-05
IL97760A0 (en) 1992-06-21
FI911584A0 (fi) 1991-04-02
HU911091D0 (en) 1991-10-28
PT97254A (pt) 1992-01-31
RU2060255C1 (ru) 1996-05-20
HU211464A9 (en) 1995-11-28
NO177266C (no) 1995-08-16
HUT60734A (en) 1992-10-28
CS9100906A2 (en) 1991-11-12
PT97254B (pt) 1998-07-31
ZA912458B (en) 1991-12-24
ATE124696T1 (de) 1995-07-15
NO177266B (no) 1995-05-08
RU95108590A (ru) 1997-03-20
NO911302L (no) 1991-10-07
AU5256093A (en) 1994-02-24
CN1031940C (zh) 1996-06-05
MY109937A (en) 1997-10-31
US5350751A (en) 1994-09-27
NZ237644A (en) 1994-12-22
CN1105993A (zh) 1995-08-02
CN1036263C (zh) 1997-10-29
CN1055361A (zh) 1991-10-16
DK0450566T3 (da) 1995-10-30
CZ280248B6 (cs) 1995-12-13
NO911302D0 (no) 1991-04-03
JP3212036B2 (ja) 2001-09-25
AU7401391A (en) 1991-10-10
MX25204A (es) 1993-08-01
KR910018376A (ko) 1991-11-30
DE4010797A1 (de) 1991-10-10
FI911584A (fi) 1991-10-05
DE59105897D1 (de) 1995-08-10
EP0450566A1 (de) 1991-10-09
RU2092482C1 (ru) 1997-10-10
JPH04234876A (ja) 1992-08-24
AU644857B2 (en) 1993-12-23
IE911098A1 (en) 1991-10-09
US5440046A (en) 1995-08-08
IL97760A (en) 1997-06-10
MA22112A1 (fr) 1991-12-31
NZ260561A (en) 1995-01-27
SK278797B6 (sk) 1998-03-04
HU213096B (en) 1997-02-28

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