BR112016029338A2 - creme transdérmico - Google Patents

creme transdérmico

Info

Publication number
BR112016029338A2
BR112016029338A2 BR112016029338A BR112016029338A BR112016029338A2 BR 112016029338 A2 BR112016029338 A2 BR 112016029338A2 BR 112016029338 A BR112016029338 A BR 112016029338A BR 112016029338 A BR112016029338 A BR 112016029338A BR 112016029338 A2 BR112016029338 A2 BR 112016029338A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
transdermal
progesterone
limonene
propylene glycol
Prior art date
Application number
BR112016029338A
Other languages
English (en)
Inventor
Ghanta Ajay
Shadiack Annette
Legassie Jason
Amadio Julia
Persicaner Peter
Winneker Richard
Thorsteinsson Thorsteinn
Original Assignee
Therapeuticsmd Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therapeuticsmd Inc filed Critical Therapeuticsmd Inc
Publication of BR112016029338A2 publication Critical patent/BR112016029338A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Abstract

resumo "creme transdérmico" a presente revelação se refere a composições farmacêuticas transdérmicas contendo progesterona em combinação com um ou mais agentes de solubilização e intensificadores de penetração, em que as composições farmacêuticas são formuladas como cremes para administração tópica. em algumas modalidades, as composições farmacêuticas transdérmicas contêm progesterona, um óleo de cadeia média e d-limoneno. em algumas modalidades, as composições farmacêuticas transdérmicas contêm progesterona, um óleo de cadeia média, um intensificador de penetração (por exemplo, propileno glicol, um éster de ácido graxo de propileno glicol, um éter de glicol) e opcionalmente d-limoneno. em certas modalidades, as composições farmacêuticas incluem ainda estradiol. métodos para tratar condições associadas à deficiência de hormônio em um sujeito são também descritos.
BR112016029338A 2014-07-29 2015-07-29 creme transdérmico BR112016029338A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462030540P 2014-07-29 2014-07-29
US201562152674P 2015-04-24 2015-04-24
PCT/US2015/042621 WO2016018993A1 (en) 2014-07-29 2015-07-29 Transdermal cream

Publications (1)

Publication Number Publication Date
BR112016029338A2 true BR112016029338A2 (pt) 2017-08-22

Family

ID=55178912

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016029338A BR112016029338A2 (pt) 2014-07-29 2015-07-29 creme transdérmico

Country Status (11)

Country Link
US (2) US10098894B2 (pt)
EP (1) EP3174542A4 (pt)
JP (1) JP2017523138A (pt)
KR (1) KR20170040209A (pt)
AU (1) AU2015296609A1 (pt)
BR (1) BR112016029338A2 (pt)
CA (1) CA2951284A1 (pt)
IL (1) IL248984A0 (pt)
MX (1) MX2016013693A (pt)
RU (1) RU2016141135A (pt)
WO (1) WO2016018993A1 (pt)

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