HUP0001739A2 - Gyógyászati hatóanyagok behatolását fokozó oldószerrendszert tartalmazó helyileg alkalmazott készítmények, valamint pufferolt oldószerrendszer alkalmazása - Google Patents

Gyógyászati hatóanyagok behatolását fokozó oldószerrendszert tartalmazó helyileg alkalmazott készítmények, valamint pufferolt oldószerrendszer alkalmazása

Info

Publication number
HUP0001739A2
HUP0001739A2 HU0001739A HUP0001739A HUP0001739A2 HU P0001739 A2 HUP0001739 A2 HU P0001739A2 HU 0001739 A HU0001739 A HU 0001739A HU P0001739 A HUP0001739 A HU P0001739A HU P0001739 A2 HUP0001739 A2 HU P0001739A2
Authority
HU
Hungary
Prior art keywords
solvent system
buffer
pharmaceutical compounds
enhanced penetration
medicinal
Prior art date
Application number
HU0001739A
Other languages
English (en)
Inventor
Jue-Chen Liu
Chakradhara Rao
Jonas C. T. Wang
Original Assignee
Johnson & Johnson Consumer Companies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson Consumer Companies, Inc. filed Critical Johnson & Johnson Consumer Companies, Inc.
Publication of HUP0001739A2 publication Critical patent/HUP0001739A2/hu
Publication of HUP0001739A3 publication Critical patent/HUP0001739A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány szerinti helyileg alkalmazott készítmények a) helyilegaktív gyógyászati vegyületet vagy hatóanyagot és b) pufferoltoldószerrendszert, amely áll i) illékony oldószerkomponensből, ii) nemillékony oldószerkomponensből és iii) pufferkomponensből, amely akészítmények pH-ját olyan értéken tartja, amelynél a gyógyászativegyület lényegileg ionizálatlan állapotban marad, tartalmaznak. A találmány tárgyköréhez tartozik továbbá pufferoltoldószerrendszer alkalmazása gyógyászati készítményekben helyilegaktív gyógyá- szati komponensek behatolásának fokozására. Ó
HU0001739A 1997-03-31 1998-03-03 Solvent system for enhanced penetration of pharmaceutical compounds for topical use and the use of the buffer solvent system HUP0001739A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82909197A 1997-03-31 1997-03-31

Publications (2)

Publication Number Publication Date
HUP0001739A2 true HUP0001739A2 (hu) 2000-12-28
HUP0001739A3 HUP0001739A3 (en) 2001-04-28

Family

ID=25253504

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001739A HUP0001739A3 (en) 1997-03-31 1998-03-03 Solvent system for enhanced penetration of pharmaceutical compounds for topical use and the use of the buffer solvent system

Country Status (14)

Country Link
EP (1) EP0971746A1 (hu)
JP (1) JP2001518879A (hu)
KR (1) KR19980081207A (hu)
CN (1) CN1252003A (hu)
AR (1) AR012217A1 (hu)
AU (1) AU6677698A (hu)
BR (1) BR9811458A (hu)
CA (1) CA2285368A1 (hu)
CO (1) CO5050328A1 (hu)
HU (1) HUP0001739A3 (hu)
IL (1) IL132096A0 (hu)
PL (1) PL335934A1 (hu)
WO (1) WO1998043673A1 (hu)
ZA (1) ZA982662B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2232855C (en) * 1997-04-10 2007-10-09 Roche Consumer Health (Worldwide) Sa Pharmaceutical formulation
WO2000072818A1 (en) * 1999-05-27 2000-12-07 The Procter & Gamble Company Topical compositions providing improved treatment of skin or scalp fungal infections
GB0103046D0 (en) * 2001-02-07 2001-03-21 Novartis Ag Organic Compounds
IL142037A0 (en) * 2001-03-15 2002-03-10 Agis Ind 1983 Ltd Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug
MY129350A (en) * 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
JP5435836B2 (ja) * 2003-07-03 2014-03-05 大正製薬株式会社 外用抗真菌剤組成物
JP4784051B2 (ja) * 2003-07-03 2011-09-28 大正製薬株式会社 容器への吸着を防止した外用抗真菌組成物
DE102005059742A1 (de) 2005-12-13 2007-06-14 Beiersdorf Ag Transparentes Sonnenschutzmittel
US20080032994A1 (en) 2006-08-03 2008-02-07 Marcel Borgers Modified azole compounds as antifungal and antibacterial agents
ES2349906T3 (es) * 2007-07-25 2011-01-12 Ixodes Gmbh Composición antibiótica tópica para prevenir la enfermedad de lyme.
KR101184834B1 (ko) * 2007-08-27 2012-09-20 니혼노야쿠가부시키가이샤 진균성 피부염용제
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
US9839611B2 (en) * 2013-09-10 2017-12-12 Insys Development Company, Inc. Sublingual buprenorphine spray
CA2924748C (en) 2013-10-03 2019-09-03 Dow Pharmaceutical Sciences, Inc. Stabilized efinaconazole formulations
CN112999223A (zh) 2013-11-22 2021-06-22 博世健康爱尔兰有限公司 抗感染的方法、组合物和装置
CN115745757B (zh) * 2022-11-07 2024-04-26 中国人民解放军军事科学院军事医学研究院 一种液态多甘醇柱芳烃衍生物的合成及对经皮药效分子缓释的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT89837B (pt) * 1988-02-29 1994-01-31 Pfizer Processo para a preparacao de composicoes para aumentar o fluxo transdermico contendo uma 1-alquilazaciclo-heptan-2-ona ou uma cis-olefina
GB8827822D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
CN1106259A (zh) * 1994-02-05 1995-08-09 日东制药株式会社 含有作为有效成分的丙酸类非类固醇性药物的新颖消炎镇痛外用凝胶制剂

Also Published As

Publication number Publication date
BR9811458A (pt) 2000-09-19
PL335934A1 (en) 2000-05-22
IL132096A0 (en) 2001-03-19
AR012217A1 (es) 2000-09-27
KR19980081207A (ko) 1998-11-25
HUP0001739A3 (en) 2001-04-28
WO1998043673A1 (en) 1998-10-08
CN1252003A (zh) 2000-05-03
CO5050328A1 (es) 2001-06-27
EP0971746A1 (en) 2000-01-19
JP2001518879A (ja) 2001-10-16
ZA982662B (en) 1999-09-30
CA2285368A1 (en) 1998-10-08
AU6677698A (en) 1998-10-22

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