DE602004014910D1 - Verfahren zur herstellung von derivaten chiraler beta-aminosäuren durch assymetrische hydrierung - Google Patents

Verfahren zur herstellung von derivaten chiraler beta-aminosäuren durch assymetrische hydrierung

Info

Publication number
DE602004014910D1
DE602004014910D1 DE602004014910T DE602004014910T DE602004014910D1 DE 602004014910 D1 DE602004014910 D1 DE 602004014910D1 DE 602004014910 T DE602004014910 T DE 602004014910T DE 602004014910 T DE602004014910 T DE 602004014910T DE 602004014910 D1 DE602004014910 D1 DE 602004014910D1
Authority
DE
Germany
Prior art keywords
preparation
amino acids
beta amino
chiral beta
derivative chiral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004014910T
Other languages
English (en)
Inventor
Yi Xiao
Joseph D Armstrong
Shane W Krska
Eugenia Njolito
Nelo R Rivera
Yongkui Sun
Thorsten Rosner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33098076&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602004014910(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE602004014910D1 publication Critical patent/DE602004014910D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0261—Complexes comprising ligands with non-tetrahedral chirality
    • B01J2531/0263—Planar chiral ligands, e.g. derived from donor-substituted paracyclophanes and metallocenes or from substituted arenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0286—Complexes comprising ligands or other components characterized by their function
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84—Metals of the iron group
    • B01J2531/842—Iron
DE602004014910T 2003-03-19 2004-03-15 Verfahren zur herstellung von derivaten chiraler beta-aminosäuren durch assymetrische hydrierung Expired - Lifetime DE602004014910D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45593203P 2003-03-19 2003-03-19
PCT/US2004/007793 WO2004085378A1 (en) 2003-03-19 2004-03-15 Process for the preparation of chiral beta amino acid derivatives by asymmetric hydrogenation

Publications (1)

Publication Number Publication Date
DE602004014910D1 true DE602004014910D1 (de) 2008-08-21

Family

ID=33098076

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004014910T Expired - Lifetime DE602004014910D1 (de) 2003-03-19 2004-03-15 Verfahren zur herstellung von derivaten chiraler beta-aminosäuren durch assymetrische hydrierung

Country Status (12)

Country Link
US (1) US7468459B2 (de)
EP (1) EP1606243B1 (de)
JP (3) JP4503594B2 (de)
CN (1) CN100339354C (de)
AR (2) AR043515A1 (de)
AT (1) ATE400545T1 (de)
AU (2) AU2004223885B2 (de)
CA (1) CA2518435C (de)
DE (1) DE602004014910D1 (de)
ES (1) ES2307000T3 (de)
TW (1) TWI312772B (de)
WO (1) WO2004085378A1 (de)

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CN109234327A (zh) * 2017-07-11 2019-01-18 上海弈柯莱生物医药科技有限公司 一种立体选择性的转氨酶在不对称合成手性胺中的应用
CN108178761A (zh) * 2017-12-28 2018-06-19 安庆奇创药业有限公司 一种西格列汀的合成方法
CN108929345B (zh) * 2018-07-18 2021-03-19 中国人民解放军第四军医大学 手性二茂铁双膦配体及其制备方法和应用
CN109761988B (zh) * 2019-01-17 2021-07-23 深圳市第二人民医院 治疗糖尿病的药物西他列汀的制备方法
CN112824422B (zh) * 2019-11-21 2023-01-13 中国科学院大连化学物理研究所 一种手性二茂铁-吲哚双膦配体及其制备方法和其应用
CN113636950B (zh) * 2020-05-11 2023-01-17 浙江医药股份有限公司新昌制药厂 一种手性4-芳基-β-氨基酸衍生物的制备方法
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CA2518435C (en) 2010-07-27
JP2010155857A (ja) 2010-07-15
ATE400545T1 (de) 2008-07-15
US7468459B2 (en) 2008-12-23
ES2307000T3 (es) 2008-11-16
AU2004223885A1 (en) 2004-10-07
TW200510273A (en) 2005-03-16
AR072877A2 (es) 2010-09-29
JP2013237674A (ja) 2013-11-28
EP1606243A1 (de) 2005-12-21
AU2009202775B2 (en) 2011-07-28
WO2004085378A1 (en) 2004-10-07
JP5663176B2 (ja) 2015-02-04
US20060194977A1 (en) 2006-08-31
EP1606243B1 (de) 2008-07-09
TWI312772B (en) 2009-08-01
AR043515A1 (es) 2005-08-03
JP4503594B2 (ja) 2010-07-14
JP2006521354A (ja) 2006-09-21
AU2009202775A1 (en) 2009-07-30
AU2004223885B2 (en) 2009-05-14
CN1761642A (zh) 2006-04-19
CN100339354C (zh) 2007-09-26

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