CN103387577A - 西格列汀碱的不对称合成方法 - Google Patents
西格列汀碱的不对称合成方法 Download PDFInfo
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- CN103387577A CN103387577A CN2013103394763A CN201310339476A CN103387577A CN 103387577 A CN103387577 A CN 103387577A CN 2013103394763 A CN2013103394763 A CN 2013103394763A CN 201310339476 A CN201310339476 A CN 201310339476A CN 103387577 A CN103387577 A CN 103387577A
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- 0 CCC(N(CCN(C1)C(CC(Cc(cc(c(C)c2)I)c2I)=N)=*)C1=*)=N Chemical compound CCC(N(CCN(C1)C(CC(Cc(cc(c(C)c2)I)c2I)=N)=*)C1=*)=N 0.000 description 1
- MFFMDFFZMYYVKS-SECBINFHSA-N N[C@@H](CC(N1Cc2nnc(C(F)(F)F)[n]2CC1)=O)Cc(cc(c(F)c1)F)c1F Chemical compound N[C@@H](CC(N1Cc2nnc(C(F)(F)F)[n]2CC1)=O)Cc(cc(c(F)c1)F)c1F MFFMDFFZMYYVKS-SECBINFHSA-N 0.000 description 1
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104628732A (zh) * | 2015-01-30 | 2015-05-20 | 吉林修正药业新药开发有限公司 | 一种三氮唑吡嗪的合成方法 |
CN108178761A (zh) * | 2017-12-28 | 2018-06-19 | 安庆奇创药业有限公司 | 一种西格列汀的合成方法 |
CN114891004A (zh) * | 2017-12-23 | 2022-08-12 | 浙江九洲药业股份有限公司 | 一种西格列汀中间体化合物的制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100339354C (zh) * | 2003-03-19 | 2007-09-26 | 默克公司 | 通过不对称氢化来制备手性β-氨基酸衍生物的方法 |
CN100430397C (zh) * | 2003-06-24 | 2008-11-05 | 默克公司 | 二肽基肽酶-iv抑制剂的磷酸盐 |
WO2010032264A2 (en) * | 2008-08-27 | 2010-03-25 | Cadila Healthcare Limited | Improved process for preparation of (2r)-4-oxo-4-[3- (trifluoromethyl)-5,6-dihydro [1,2,4]-triazolo[4,3-a]pyrazin- 7(8h)-yl]-l-(2,4,5-trifluorophenyl)butan-2-amine & new impurities in preparation thereof |
CN101903390A (zh) * | 2007-12-20 | 2010-12-01 | 雷迪博士实验室有限公司 | 制备西他列汀及其药学上可接受的盐的方法 |
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- 2013-07-29 CN CN2013103394763A patent/CN103387577A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100339354C (zh) * | 2003-03-19 | 2007-09-26 | 默克公司 | 通过不对称氢化来制备手性β-氨基酸衍生物的方法 |
CN100430397C (zh) * | 2003-06-24 | 2008-11-05 | 默克公司 | 二肽基肽酶-iv抑制剂的磷酸盐 |
CN101903390A (zh) * | 2007-12-20 | 2010-12-01 | 雷迪博士实验室有限公司 | 制备西他列汀及其药学上可接受的盐的方法 |
WO2010032264A2 (en) * | 2008-08-27 | 2010-03-25 | Cadila Healthcare Limited | Improved process for preparation of (2r)-4-oxo-4-[3- (trifluoromethyl)-5,6-dihydro [1,2,4]-triazolo[4,3-a]pyrazin- 7(8h)-yl]-l-(2,4,5-trifluorophenyl)butan-2-amine & new impurities in preparation thereof |
Non-Patent Citations (2)
Title |
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XIAO-YU ZHOU ET AL.: "Palladium-catalyzed asymmetric hydrogenation of simple ketimines using a bronsted acid as activator", 《ADVANCED SYNTHESIS & CATALYSIS》 * |
叶飞等: "西他列汀外消旋体的合成及拆分", 《合成化学》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104628732A (zh) * | 2015-01-30 | 2015-05-20 | 吉林修正药业新药开发有限公司 | 一种三氮唑吡嗪的合成方法 |
CN104628732B (zh) * | 2015-01-30 | 2017-02-22 | 吉林修正药业新药开发有限公司 | 一种三氮唑吡嗪的合成方法 |
CN114891004A (zh) * | 2017-12-23 | 2022-08-12 | 浙江九洲药业股份有限公司 | 一种西格列汀中间体化合物的制备方法 |
CN114891004B (zh) * | 2017-12-23 | 2024-01-05 | 浙江九洲药业股份有限公司 | 一种西格列汀中间体化合物的制备方法 |
CN108178761A (zh) * | 2017-12-28 | 2018-06-19 | 安庆奇创药业有限公司 | 一种西格列汀的合成方法 |
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Effective date of registration: 20151027 Address after: Economic and Technological Development Zone of Shandong Province, Weihai City, Gushan Town, 264209 No. 18 South Road, No. 19 North Road, No. 3 East Road, the west five Applicant after: Weihai Disu Pharmaceutical Co., Ltd. Address before: 264209 No. 196, science and technology road, torch hi tech Industrial Development Zone, Shandong, Weihai Applicant before: Disha Pharmaceutical Group Shandong Disha Pharmaceutical Co., Ltd. |
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