AR072877A2 - Una forma cristalina de (2r) -4-oxo-4-[3- (trifluorometil ) -5,6-dihidro -.[1,2,4 ] - triazolo [4,3-a ] pirazin-7 (8h ) -il] -1- (2,4,5,-trifluoro fenil ) butan -2-amina - Google Patents
Una forma cristalina de (2r) -4-oxo-4-[3- (trifluorometil ) -5,6-dihidro -.[1,2,4 ] - triazolo [4,3-a ] pirazin-7 (8h ) -il] -1- (2,4,5,-trifluoro fenil ) butan -2-aminaInfo
- Publication number
- AR072877A2 AR072877A2 ARP090102853A ARP090102853A AR072877A2 AR 072877 A2 AR072877 A2 AR 072877A2 AR P090102853 A ARP090102853 A AR P090102853A AR P090102853 A ARP090102853 A AR P090102853A AR 072877 A2 AR072877 A2 AR 072877A2
- Authority
- AR
- Argentina
- Prior art keywords
- triazolo
- butan
- oxo
- pirazin
- trifluorometil
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
- B01J2531/0261—Complexes comprising ligands with non-tetrahedral chirality
- B01J2531/0263—Planar chiral ligands, e.g. derived from donor-substituted paracyclophanes and metallocenes or from substituted arenes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
- B01J2531/0286—Complexes comprising ligands or other components characterized by their function
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/822—Rhodium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/84—Metals of the iron group
- B01J2531/842—Iron
Abstract
Una forma cristalina de (2R)-4-oxo-4-[3-(trifluorometil)-5,6-dihidro[1,2,4]-triazolo[4,3-a]pirazin-7(8H)-il]-1-(2,4,5-trifluorofenil)butan-2-amina de formula estructural (2-5) que tiene un punto de fusion entre 114.1 y 115.7°C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45593203P | 2003-03-19 | 2003-03-19 |
Publications (1)
Publication Number | Publication Date |
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AR072877A2 true AR072877A2 (es) | 2010-09-29 |
Family
ID=33098076
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040100745A AR043515A1 (es) | 2003-03-19 | 2004-03-09 | Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica |
ARP090102853A AR072877A2 (es) | 2003-03-19 | 2009-07-27 | Una forma cristalina de (2r) -4-oxo-4-[3- (trifluorometil ) -5,6-dihidro -.[1,2,4 ] - triazolo [4,3-a ] pirazin-7 (8h ) -il] -1- (2,4,5,-trifluoro fenil ) butan -2-amina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040100745A AR043515A1 (es) | 2003-03-19 | 2004-03-09 | Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica |
Country Status (12)
Country | Link |
---|---|
US (1) | US7468459B2 (es) |
EP (1) | EP1606243B1 (es) |
JP (3) | JP4503594B2 (es) |
CN (1) | CN100339354C (es) |
AR (2) | AR043515A1 (es) |
AT (1) | ATE400545T1 (es) |
AU (2) | AU2004223885B2 (es) |
CA (1) | CA2518435C (es) |
DE (1) | DE602004014910D1 (es) |
ES (1) | ES2307000T3 (es) |
TW (1) | TWI312772B (es) |
WO (1) | WO2004085378A1 (es) |
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DE19956414A1 (de) | 1999-11-24 | 2001-06-13 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von chiralen Aminen durch homogen katalysierte asymmetrische Hydrierung von Enaminen |
JP4742484B2 (ja) * | 2000-02-22 | 2011-08-10 | ロンザ アーゲー | 3−アミノアルカン酸エステルの製造方法 |
CN1349994A (zh) * | 2000-10-25 | 2002-05-22 | 中国科学院上海有机化学研究所 | 一种具有二茂铁修饰的手性口袋的双膦配体、合成及应用 |
EP1341797A4 (en) * | 2000-11-17 | 2005-06-15 | Penn State Res Found | ORTHO-SUBSTITUTED CHIRAL PHOSPHINES AND PHOSPHINITES AND THEIR USE IN ASYMMETRIC CATALYTIC REACTIONS |
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JP4368632B2 (ja) * | 2002-07-30 | 2009-11-18 | 高砂香料工業株式会社 | 光学活性β−アミノ酸類の製造方法 |
EP1386901B1 (en) | 2002-07-30 | 2015-07-01 | Takasago International Corporation | Method for producing an optically active beta-amino acid |
TW200602293A (en) | 2004-04-05 | 2006-01-16 | Merck & Co Inc | Process for the preparation of enantiomerically enriched beta amino acid derivatives |
-
2004
- 2004-03-09 AR ARP040100745A patent/AR043515A1/es active IP Right Grant
- 2004-03-15 WO PCT/US2004/007793 patent/WO2004085378A1/en active Application Filing
- 2004-03-15 US US10/549,425 patent/US7468459B2/en active Active
- 2004-03-15 JP JP2006507177A patent/JP4503594B2/ja not_active Expired - Lifetime
- 2004-03-15 DE DE602004014910T patent/DE602004014910D1/de not_active Expired - Lifetime
- 2004-03-15 EP EP04720790A patent/EP1606243B1/en not_active Expired - Lifetime
- 2004-03-15 ES ES04720790T patent/ES2307000T3/es not_active Expired - Lifetime
- 2004-03-15 AU AU2004223885A patent/AU2004223885B2/en not_active Expired
- 2004-03-15 CN CNB2004800073134A patent/CN100339354C/zh not_active Expired - Lifetime
- 2004-03-15 CA CA2518435A patent/CA2518435C/en not_active Expired - Lifetime
- 2004-03-15 AT AT04720790T patent/ATE400545T1/de active
- 2004-03-18 TW TW093107261A patent/TWI312772B/zh active
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- 2009-07-08 AU AU2009202775A patent/AU2009202775B2/en not_active Expired
- 2009-07-27 AR ARP090102853A patent/AR072877A2/es not_active Application Discontinuation
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- 2010-03-05 JP JP2010048680A patent/JP5663176B2/ja not_active Expired - Lifetime
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TW200510273A (en) | 2005-03-16 |
AU2009202775B2 (en) | 2011-07-28 |
AU2004223885A1 (en) | 2004-10-07 |
CA2518435A1 (en) | 2004-10-07 |
JP2010155857A (ja) | 2010-07-15 |
AR043515A1 (es) | 2005-08-03 |
EP1606243B1 (en) | 2008-07-09 |
JP2013237674A (ja) | 2013-11-28 |
AU2004223885B2 (en) | 2009-05-14 |
AU2009202775A1 (en) | 2009-07-30 |
CA2518435C (en) | 2010-07-27 |
JP5663176B2 (ja) | 2015-02-04 |
CN100339354C (zh) | 2007-09-26 |
US20060194977A1 (en) | 2006-08-31 |
JP4503594B2 (ja) | 2010-07-14 |
JP2006521354A (ja) | 2006-09-21 |
EP1606243A1 (en) | 2005-12-21 |
ATE400545T1 (de) | 2008-07-15 |
CN1761642A (zh) | 2006-04-19 |
DE602004014910D1 (de) | 2008-08-21 |
WO2004085378A1 (en) | 2004-10-07 |
ES2307000T3 (es) | 2008-11-16 |
TWI312772B (en) | 2009-08-01 |
US7468459B2 (en) | 2008-12-23 |
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