DE60141043D1 - Rekombinante anti-cd30-antikörper und deren verwendungen - Google Patents
Rekombinante anti-cd30-antikörper und deren verwendungenInfo
- Publication number
- DE60141043D1 DE60141043D1 DE60141043T DE60141043T DE60141043D1 DE 60141043 D1 DE60141043 D1 DE 60141043D1 DE 60141043 T DE60141043 T DE 60141043T DE 60141043 T DE60141043 T DE 60141043T DE 60141043 D1 DE60141043 D1 DE 60141043D1
- Authority
- DE
- Germany
- Prior art keywords
- proteins
- hodgkin
- disease
- antibodies
- hefi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 208000017604 Hodgkin disease Diseases 0.000 abstract 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 abstract 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 abstract 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940044683 chemotherapy drug Drugs 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/724,406 US7090843B1 (en) | 2000-11-28 | 2000-11-28 | Recombinant anti-CD30 antibodies and uses thereof |
| PCT/US2001/044811 WO2002043661A2 (en) | 2000-11-28 | 2001-11-28 | Recombinant anti-cd30 antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60141043D1 true DE60141043D1 (de) | 2010-02-25 |
Family
ID=24910311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60141043T Expired - Lifetime DE60141043D1 (de) | 2000-11-28 | 2001-11-28 | Rekombinante anti-cd30-antikörper und deren verwendungen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7090843B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1347730B2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4303964B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE454124T1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU3651802A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2430135C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1110700T1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60141043D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1347730T4 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2339333T5 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1347730E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002043661A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040018194A1 (en) * | 2000-11-28 | 2004-01-29 | Francisco Joseph A. | Recombinant anti-CD30 antibodies and uses thereof |
| US7090843B1 (en) † | 2000-11-28 | 2006-08-15 | Seattle Genetics, Inc. | Recombinant anti-CD30 antibodies and uses thereof |
| US20110313230A1 (en) | 2001-05-11 | 2011-12-22 | Terrance Grant Johns | Specific binding proteins and uses thereof |
| EP1482972A4 (en) * | 2001-11-20 | 2005-11-23 | Seattle Genetics Inc | TREATMENT OF IMMUNOLOGICAL DISORDERS USING ANTI-CD30 ANTIBODIES |
| WO2003055527A2 (en) * | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
| KR100829283B1 (ko) * | 2002-01-09 | 2008-05-13 | 메다렉스, 인코포레이티드 | Cd30에 대한 인간 모노클로날 항체 |
| US20070148171A1 (en) * | 2002-09-27 | 2007-06-28 | Xencor, Inc. | Optimized anti-CD30 antibodies |
| EP2353611B1 (en) * | 2002-07-31 | 2015-05-13 | Seattle Genetics, Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
| KR101520209B1 (ko) | 2003-11-06 | 2015-05-13 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
| MX2007003533A (es) | 2004-10-01 | 2007-05-23 | Medarex Inc | Metodos de tratar linfomas cd30 positivas. |
| MX2007009940A (es) | 2005-02-18 | 2007-10-10 | Medarex Inc | Anticuerpos monoclonales que carecen de residuos fucosilo contra cd30. |
| JP4860703B2 (ja) | 2005-10-06 | 2012-01-25 | ゼンコー・インコーポレイテッド | 最適化された抗cd30抗体 |
| WO2008025020A2 (en) * | 2006-08-25 | 2008-02-28 | Seattle Genetics, Inc. | Cd30 binding agents and uses thereof |
| JP5469600B2 (ja) | 2007-07-16 | 2014-04-16 | ジェネンテック, インコーポレイテッド | 抗CD79b抗体及びイムノコンジュゲートとその使用方法 |
| SG183044A1 (en) | 2007-07-16 | 2012-08-30 | Genentech Inc | Humanized anti-cd79b antibodies and immunoconjugatesand methods of use |
| US8865875B2 (en) | 2007-08-22 | 2014-10-21 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions |
| WO2009048967A1 (en) | 2007-10-12 | 2009-04-16 | Seattle Genetics, Inc. | Combination therapy with antibody-drug conjugates |
| UA106586C2 (uk) | 2008-01-31 | 2014-09-25 | Дженентек, Інк. | Анти-cd79b антитіла, і імунокон'югати та способи їх застосування |
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| KR101224468B1 (ko) * | 2009-05-20 | 2013-01-23 | 주식회사 파멥신 | 신규한 형태의 이중표적항체 및 그 용도 |
| US20110076232A1 (en) | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| TWI545134B (zh) | 2010-10-22 | 2016-08-11 | 西雅圖遺傳學公司 | 以奧裡斯他汀(AURISTATIN)為主之抗體藥物結合物及PI3K-AKT mTOR路徑抑制劑間的協同功效 |
| US9717803B2 (en) | 2011-12-23 | 2017-08-01 | Innate Pharma | Enzymatic conjugation of polypeptides |
| KR20180137614A (ko) * | 2012-04-27 | 2018-12-27 | 노보 노르디스크 에이/에스 | 사람 cd30 리간드 항원 결합 단백질 |
| US10132799B2 (en) | 2012-07-13 | 2018-11-20 | Innate Pharma | Screening of conjugated antibodies |
| WO2014057687A1 (ja) | 2012-10-11 | 2014-04-17 | 第一三共株式会社 | 抗体-薬物コンジュゲート |
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-
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- 2000-11-28 US US09/724,406 patent/US7090843B1/en not_active Expired - Lifetime
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- 2001-11-28 JP JP2002545640A patent/JP4303964B2/ja not_active Expired - Lifetime
- 2001-11-28 ES ES01986050T patent/ES2339333T5/es not_active Expired - Lifetime
- 2001-11-28 DK DK01986050.1T patent/DK1347730T4/da active
- 2001-11-28 WO PCT/US2001/044811 patent/WO2002043661A2/en not_active Ceased
- 2001-11-28 AU AU3651802A patent/AU3651802A/xx active Pending
- 2001-11-28 CA CA2430135A patent/CA2430135C/en not_active Expired - Lifetime
- 2001-11-28 AU AU2002236518A patent/AU2002236518B2/en active Active
- 2001-11-28 AT AT01986050T patent/ATE454124T1/de active
- 2001-11-28 EP EP01986050.1A patent/EP1347730B2/en not_active Expired - Lifetime
- 2001-11-28 DE DE60141043T patent/DE60141043D1/de not_active Expired - Lifetime
- 2001-11-28 PT PT01986050T patent/PT1347730E/pt unknown
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| Publication number | Publication date |
|---|---|
| WO2002043661A3 (en) | 2003-01-16 |
| EP1347730A2 (en) | 2003-10-01 |
| PT1347730E (pt) | 2010-03-03 |
| EP1347730A4 (en) | 2005-08-17 |
| AU3651802A (en) | 2002-06-11 |
| WO2002043661A2 (en) | 2002-06-06 |
| ES2339333T3 (es) | 2010-05-19 |
| EP1347730B1 (en) | 2010-01-06 |
| CY1110700T1 (el) | 2015-06-10 |
| CA2430135C (en) | 2012-10-02 |
| ATE454124T1 (de) | 2010-01-15 |
| DK1347730T4 (da) | 2020-04-27 |
| US7090843B1 (en) | 2006-08-15 |
| WO2002043661B1 (en) | 2003-03-06 |
| JP2005506035A (ja) | 2005-03-03 |
| DK1347730T3 (da) | 2010-02-01 |
| JP4303964B2 (ja) | 2009-07-29 |
| AU2002236518B2 (en) | 2006-10-26 |
| ES2339333T5 (es) | 2013-09-26 |
| EP1347730B2 (en) | 2013-05-29 |
| CA2430135A1 (en) | 2002-06-06 |
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