DE60131160T2 - Caspase-inhibitoren und ihre verwendungen - Google Patents

Caspase-inhibitoren und ihre verwendungen Download PDF

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Publication number
DE60131160T2
DE60131160T2 DE60131160T DE60131160T DE60131160T2 DE 60131160 T2 DE60131160 T2 DE 60131160T2 DE 60131160 T DE60131160 T DE 60131160T DE 60131160 T DE60131160 T DE 60131160T DE 60131160 T2 DE60131160 T2 DE 60131160T2
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disease
compound according
treatment
caspase
compound
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DE60131160T
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English (en)
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DE60131160D1 (de
Inventor
Jean-Damien Vertex Pharmaceuticals I Charrier
Guy Vertex Pharmaceuticals Ltd. Oxon BRENCHLEY
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Neurology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
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  • Addiction (AREA)
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DE60131160T 2000-06-07 2001-06-05 Caspase-inhibitoren und ihre verwendungen Expired - Lifetime DE60131160T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20992900P 2000-06-07 2000-06-07
US209929P 2000-06-07
PCT/US2001/018243 WO2001094351A1 (en) 2000-06-07 2001-06-05 Caspase inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
DE60131160D1 DE60131160D1 (de) 2007-12-13
DE60131160T2 true DE60131160T2 (de) 2008-08-07

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DE60131160T Expired - Lifetime DE60131160T2 (de) 2000-06-07 2001-06-05 Caspase-inhibitoren und ihre verwendungen

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Country Link
US (3) US7407964B2 (https=)
EP (1) EP1289993B9 (https=)
JP (1) JP2003535865A (https=)
KR (1) KR20030025235A (https=)
AT (1) ATE377010T1 (https=)
AU (2) AU7527901A (https=)
CA (1) CA2409015A1 (https=)
DE (1) DE60131160T2 (https=)
ES (1) ES2295171T3 (https=)
IL (1) IL152845A0 (https=)
WO (1) WO2001094351A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355618B1 (en) 1999-04-09 2002-03-12 Cytovia, Inc. Caspase inhibitors and the use thereof
DE60010675T2 (de) 1999-08-06 2005-06-16 Vertex Pharmaceuticals Inc., Cambridge Caspase inhibitoren und deren verwendung
US6495522B1 (en) 1999-08-27 2002-12-17 Cytovia, Inc. Substituted alpha-hydroxy acid caspase inhibitors and the use thereof
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
WO2001094351A1 (en) * 2000-06-07 2001-12-13 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
US7410956B2 (en) 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
AU2003225088A1 (en) 2002-04-19 2003-11-03 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
PL374598A1 (en) 2002-06-28 2005-10-31 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
US7612091B2 (en) 2002-12-20 2009-11-03 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
NZ540729A (en) 2002-12-27 2008-03-28 Angeletti P Ist Richerche Bio Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds useful as HIV integrase inhibitors
EP1607101A4 (en) * 2003-02-24 2007-10-24 Daiichi Seiyaku Co INHIBITOR OF DEGRADATION OF PROTEIN INTERACTING WITH HEPATITIS B VIRUS PROTEIN X
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
IL158599A0 (en) * 2003-10-26 2004-05-12 Yeda Res & Dev Methods of modulating hematopoiesis
US7652153B2 (en) * 2004-02-27 2010-01-26 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
EP2399916B1 (en) * 2004-03-12 2014-12-10 Vertex Pharmaceuticals Incorporated Process and intermediates for the preparation of aspartic acetal caspase ihnhibitors
WO2005115362A1 (en) * 2004-05-15 2005-12-08 Vertex Pharmaceuticals Incorporated Treating seizures using ice inhibitors
CA2567080A1 (en) 2004-05-27 2005-12-15 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
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AU7527901A (en) 2001-12-17
ATE377010T1 (de) 2007-11-15
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US20110003824A1 (en) 2011-01-06
US7968716B2 (en) 2011-06-28
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US7829561B2 (en) 2010-11-09
US20090023739A1 (en) 2009-01-22
US7407964B2 (en) 2008-08-05
EP1289993B1 (en) 2007-10-31
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