KR20030025235A - 카스파제 억제제 및 이의 용도 - Google Patents
카스파제 억제제 및 이의 용도 Download PDFInfo
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- KR20030025235A KR20030025235A KR1020027016636A KR20027016636A KR20030025235A KR 20030025235 A KR20030025235 A KR 20030025235A KR 1020027016636 A KR1020027016636 A KR 1020027016636A KR 20027016636 A KR20027016636 A KR 20027016636A KR 20030025235 A KR20030025235 A KR 20030025235A
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- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
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Classifications
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| US60/209,929 | 2000-06-07 |
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| CN1235875C (zh) | 1999-08-27 | 2006-01-11 | 西托维亚公司 | 取代的α－羟基酸天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途 |
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| ES2614113T3 (es) * | 2004-09-17 | 2017-05-29 | Biomas Ltd. | Uso de tricloro (dioxietilen-O,O) telurato de amonio (AS101) para la inhibición de la enzima convertidora de interleucina-1 beta |
| KR20080038369A (ko) * | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
| JP2009521458A (ja) * | 2005-12-22 | 2009-06-04 | シェーリング コーポレイション | トロンビン受容体アンタゴニストとしてのオキサゾロイソキノリン誘導体 |
| DK2288615T3 (en) | 2008-05-21 | 2017-09-04 | Genesis Tech Ltd | SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF |
| WO2010017408A1 (en) | 2008-08-06 | 2010-02-11 | The Buck Institute For Age Research | Caspase inhibitors and uses thereof |
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| CN101580505B (zh) * | 2009-05-27 | 2014-09-10 | 沈阳药科大学 | 吡咯并[2，1-b]喹唑啉类天然产物的衍生物及其制备方法和用途 |
| WO2011094426A1 (en) | 2010-01-29 | 2011-08-04 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Caspase inhibitors |
| US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
| EP2697246B1 (en) | 2011-04-15 | 2018-03-07 | Genesis Technologies Limited | Selective cysteine protease inhibitors and uses thereof |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| EP4105208A1 (en) * | 2013-07-31 | 2022-12-21 | Novartis AG | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions |
| ES2751652T3 (es) | 2014-05-12 | 2020-04-01 | Conatus Pharmaceuticals Inc | Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| JP2019500397A (ja) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ，インコーポレイテッド | カスパーゼ阻害剤を肝疾患の治療に使用する方法 |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
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| AT377586B (de) * | 1981-06-30 | 1985-04-10 | Erba Farmitalia | Verfahren zur herstellung von substituierten pyrrolo-(2,1-b)-chinazolinen und pyrido(2,1-b)chinazolinen |
| US5552400A (en) * | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| NZ330451A (https=) * | 1996-09-12 | 2000-01-28 | Idun Pharmaceuticals Inc | |
| WO1998016502A1 (en) * | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
| NZ334906A (en) * | 1996-10-11 | 2000-09-29 | Basf Ag | A sulphonamido pentanoic acid derivative useful as an interleukin-1-beta converting enzyme inhibitor |
| AU1915399A (en) * | 1998-07-10 | 2000-02-01 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| EP1289993B9 (en) * | 2000-06-07 | 2008-08-20 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
-
2001
- 2001-06-05 EP EP01941972A patent/EP1289993B9/en not_active Expired - Lifetime
- 2001-06-05 CA CA002409015A patent/CA2409015A1/en not_active Abandoned
- 2001-06-05 ES ES01941972T patent/ES2295171T3/es not_active Expired - Lifetime
- 2001-06-05 AU AU7527901A patent/AU7527901A/xx active Pending
- 2001-06-05 DE DE60131160T patent/DE60131160T2/de not_active Expired - Lifetime
- 2001-06-05 WO PCT/US2001/018243 patent/WO2001094351A1/en not_active Ceased
- 2001-06-05 AU AU2001275279A patent/AU2001275279B2/en not_active Ceased
- 2001-06-05 KR KR1020027016636A patent/KR20030025235A/ko not_active Withdrawn
- 2001-06-05 AT AT01941972T patent/ATE377010T1/de not_active IP Right Cessation
- 2001-06-05 IL IL15284501A patent/IL152845A0/xx unknown
- 2001-06-05 JP JP2002501900A patent/JP2003535865A/ja active Pending
- 2001-06-07 US US09/877,832 patent/US7407964B2/en not_active Expired - Fee Related
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2008
- 2008-07-01 US US12/165,952 patent/US7829561B2/en not_active Expired - Fee Related
-
2010
- 2010-09-16 US US12/883,424 patent/US7968716B2/en not_active Expired - Fee Related
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|---|---|
| AU2001275279B2 (en) | 2007-01-04 |
| US7968716B2 (en) | 2011-06-28 |
| AU7527901A (en) | 2001-12-17 |
| DE60131160T2 (de) | 2008-08-07 |
| US7407964B2 (en) | 2008-08-05 |
| US20090023739A1 (en) | 2009-01-22 |
| ATE377010T1 (de) | 2007-11-15 |
| WO2001094351A1 (en) | 2001-12-13 |
| DE60131160D1 (de) | 2007-12-13 |
| US20020045623A1 (en) | 2002-04-18 |
| EP1289993B1 (en) | 2007-10-31 |
| US20110003824A1 (en) | 2011-01-06 |
| JP2003535865A (ja) | 2003-12-02 |
| EP1289993A1 (en) | 2003-03-12 |
| CA2409015A1 (en) | 2001-12-13 |
| US7829561B2 (en) | 2010-11-09 |
| EP1289993B9 (en) | 2008-08-20 |
| ES2295171T3 (es) | 2008-04-16 |
| IL152845A0 (en) | 2003-06-24 |
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