ATE377010T1 - Caspase-inhibitoren und ihre verwendungen - Google Patents

Caspase-inhibitoren und ihre verwendungen

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Publication number
ATE377010T1
ATE377010T1 AT01941972T AT01941972T ATE377010T1 AT E377010 T1 ATE377010 T1 AT E377010T1 AT 01941972 T AT01941972 T AT 01941972T AT 01941972 T AT01941972 T AT 01941972T AT E377010 T1 ATE377010 T1 AT E377010T1
Authority
AT
Austria
Prior art keywords
group
ring
hydrogen
aliphatic
caspase inhibitors
Prior art date
Application number
AT01941972T
Other languages
English (en)
Inventor
Jean-Damien Charrier
Guy Brenchley
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE377010T1 publication Critical patent/ATE377010T1/de

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
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  • Cardiology (AREA)
  • Molecular Biology (AREA)
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  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
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AT01941972T 2000-06-07 2001-06-05 Caspase-inhibitoren und ihre verwendungen ATE377010T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20992900P 2000-06-07 2000-06-07

Publications (1)

Publication Number Publication Date
ATE377010T1 true ATE377010T1 (de) 2007-11-15

Family

ID=22780912

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01941972T ATE377010T1 (de) 2000-06-07 2001-06-05 Caspase-inhibitoren und ihre verwendungen

Country Status (11)

Country Link
US (3) US7407964B2 (de)
EP (1) EP1289993B9 (de)
JP (1) JP2003535865A (de)
KR (1) KR20030025235A (de)
AT (1) ATE377010T1 (de)
AU (2) AU7527901A (de)
CA (1) CA2409015A1 (de)
DE (1) DE60131160T2 (de)
ES (1) ES2295171T3 (de)
IL (1) IL152845A0 (de)
WO (1) WO2001094351A1 (de)

Families Citing this family (36)

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BR0009610A (pt) 1999-04-09 2002-02-13 Cytovia Inc Inibidores de caspase e uso dos mesmos
WO2001010383A2 (en) 1999-08-06 2001-02-15 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
CA2383002A1 (en) 1999-08-27 2001-03-08 Cytovia, Inc. Substituted .alpha.-hydroxy acid caspase inhibitors and the use thereof
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
DE60131160T2 (de) * 2000-06-07 2008-08-07 Vertex Pharmaceuticals Inc., Cambridge Caspase-inhibitoren und ihre verwendungen
AU2003211052A1 (en) 2002-02-11 2003-09-04 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
AU2003225088A1 (en) 2002-04-19 2003-11-03 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
AR040350A1 (es) 2002-06-28 2005-03-30 Vertex Pharma Inhibidores de caspasa y usos de los mismos
CA2511235A1 (en) * 2002-12-20 2004-07-15 Vertex Pharmaceuticals Incorporated 4-oxo-3-(1-oxo-1h-isoquinolin-2-ylacetylamino)-pentanoic acid ester and amide derivatives and their use as caspase inhibitors
EP1578748B1 (de) 2002-12-27 2010-09-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Tetrahydro-4h-pyrido[1,2-a]pyrimidine und verwandte verbindungen verwendbar als hiv integrase hemmer
JPWO2004073742A1 (ja) * 2003-02-24 2006-06-01 第一製薬株式会社 Ｂ型肝炎ウイルスｘ相互作用蛋白質の分解阻害剤
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
IL158599A0 (en) * 2003-10-26 2004-05-12 Yeda Res & Dev Methods of modulating hematopoiesis
CN102161656B (zh) * 2004-02-27 2013-02-20 沃泰克斯药物股份有限公司 天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
CN103467459A (zh) 2004-03-12 2013-12-25 弗特克斯药品有限公司 制备化合物的方法
EP1750689A1 (de) * 2004-05-15 2007-02-14 Vertex Pharmaceuticals Incorporated Behandlung von krampfanfällen mit ice-hemmern
EP1778221A2 (de) 2004-05-27 2007-05-02 Vertex Pharmaceuticals Incorporated Ice-hemmer zur behandlung von autoinflammatorischen erkrankungen
EP1791535B1 (de) * 2004-09-17 2008-07-30 BioMAS Ltd. Neue tellurium-verbindungen und ihre verwendung als immunmodulatoren
JP2009502922A (ja) * 2005-07-28 2009-01-29 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼ阻害剤プロドラッグ
CN101384590A (zh) * 2005-12-22 2009-03-11 先灵公司 作为凝血酶受体拮抗剂的唑并异喹啉
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US7407964B2 (en) 2008-08-05
KR20030025235A (ko) 2003-03-28
DE60131160D1 (de) 2007-12-13
IL152845A0 (en) 2003-06-24
WO2001094351A1 (en) 2001-12-13
JP2003535865A (ja) 2003-12-02
ES2295171T3 (es) 2008-04-16
US20090023739A1 (en) 2009-01-22
EP1289993B9 (de) 2008-08-20
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