ATE377010T1 - Caspase-inhibitoren und ihre verwendungen - Google Patents

Caspase-inhibitoren und ihre verwendungen

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Publication number
ATE377010T1
ATE377010T1 AT01941972T AT01941972T ATE377010T1 AT E377010 T1 ATE377010 T1 AT E377010T1 AT 01941972 T AT01941972 T AT 01941972T AT 01941972 T AT01941972 T AT 01941972T AT E377010 T1 ATE377010 T1 AT E377010T1
Authority
AT
Austria
Prior art keywords
group
ring
hydrogen
aliphatic
caspase inhibitors
Prior art date
Application number
AT01941972T
Other languages
English (en)
Inventor
Jean-Damien Charrier
Guy Brenchley
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE377010T1 publication Critical patent/ATE377010T1/de

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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AT01941972T 2000-06-07 2001-06-05 Caspase-inhibitoren und ihre verwendungen ATE377010T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20992900P 2000-06-07 2000-06-07

Publications (1)

Publication Number Publication Date
ATE377010T1 true ATE377010T1 (de) 2007-11-15

Family

ID=22780912

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01941972T ATE377010T1 (de) 2000-06-07 2001-06-05 Caspase-inhibitoren und ihre verwendungen

Country Status (11)

Country Link
US (3) US7407964B2 (de)
EP (1) EP1289993B9 (de)
JP (1) JP2003535865A (de)
KR (1) KR20030025235A (de)
AT (1) ATE377010T1 (de)
AU (2) AU2001275279B2 (de)
CA (1) CA2409015A1 (de)
DE (1) DE60131160T2 (de)
ES (1) ES2295171T3 (de)
IL (1) IL152845A0 (de)
WO (1) WO2001094351A1 (de)

Families Citing this family (36)

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WO2000061542A1 (en) 1999-04-09 2000-10-19 Cytovia, Inc. Caspase inhibitors and the use thereof
AU6894800A (en) 1999-08-06 2001-03-05 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
IL148426A0 (en) 1999-08-27 2002-09-12 Cytovia Inc α-HYDROXY ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
EP1289993B9 (de) * 2000-06-07 2008-08-20 Vertex Pharmaceuticals Incorporated Caspase-inhibitoren und ihre verwendungen
US7410956B2 (en) 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
US7960398B2 (en) 2002-04-19 2011-06-14 Vertex Pharmaceuticals Incorporated Regulation of TNF-alpha
BR0312232A (pt) 2002-06-28 2005-05-10 Vertex Pharma Inibidores de caspases e seus usos
EP1581501A1 (de) * 2002-12-20 2005-10-05 Vertex Pharmaceuticals Incorporated 4-oxo-3-(1-oxo-1h-isochinolin-2-ylacetylamino)pentansäureester-und -amidderivate und deren verwendung als caspaseinhibitoren
BR0317749A (pt) * 2002-12-27 2005-11-22 Angeletti P Ist Richerche Bio Composto, composição farmacêutica, e, uso de um composto
WO2004073742A1 (ja) * 2003-02-24 2004-09-02 Daiichi Pharmaceutical Co.,Ltd. Ｂ型肝炎ウイルスx相互作用蛋白質の分解阻害剤
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
IL158599A0 (en) * 2003-10-26 2004-05-12 Yeda Res & Dev Methods of modulating hematopoiesis
AU2005249503B2 (en) 2003-11-10 2011-08-25 Vertex Pharmaceuticals Incorporated ICE inhibitors for the treatment of autoinflammatory diseases
EP1718639A2 (de) 2004-02-27 2006-11-08 Vertex Pharmaceuticals Incorporated Caspaseinhibitoren und deren verwendungen
KR101135765B1 (ko) * 2004-03-12 2012-04-23 버텍스 파마슈티칼스 인코포레이티드 아스파르트산 아세탈 카스파아제 억제제의 제조를 위한방법 및 중간체
CA2566362C (en) * 2004-05-15 2013-09-10 Vertex Pharmaceuticals Incorporated Treating seizures using ice inhibitors
ES2614113T3 (es) * 2004-09-17 2017-05-29 Biomas Ltd. Uso de tricloro (dioxietilen-O,O’) telurato de amonio (AS101) para la inhibición de la enzima convertidora de interleucina-1 beta
EP1910379B1 (de) * 2005-07-28 2011-10-19 Vertex Pharmaceuticals Incorporated Caspase-hemmer-propharmaka
WO2007075809A2 (en) * 2005-12-22 2007-07-05 Schering Corporation Oxazoloisoquinoline derivatives as thrombin receptor antagonists
DK2288615T3 (en) 2008-05-21 2017-09-04 Genesis Tech Ltd SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF
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DE60131160T2 (de) 2008-08-07
US7829561B2 (en) 2010-11-09
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US7407964B2 (en) 2008-08-05
AU2001275279B2 (en) 2007-01-04
US20110003824A1 (en) 2011-01-06
US20020045623A1 (en) 2002-04-18
EP1289993B9 (de) 2008-08-20
US20090023739A1 (en) 2009-01-22
CA2409015A1 (en) 2001-12-13
KR20030025235A (ko) 2003-03-28
IL152845A0 (en) 2003-06-24
EP1289993B1 (de) 2007-10-31
US7968716B2 (en) 2011-06-28
WO2001094351A1 (en) 2001-12-13
AU7527901A (en) 2001-12-17
EP1289993A1 (de) 2003-03-12
ES2295171T3 (es) 2008-04-16

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