DE69903923T2 - Bizyklische pyrrolderivate als mcp-1 inhibitoren - Google Patents
Bizyklische pyrrolderivate als mcp-1 inhibitorenInfo
- Publication number
- DE69903923T2 DE69903923T2 DE69903923T DE69903923T DE69903923T2 DE 69903923 T2 DE69903923 T2 DE 69903923T2 DE 69903923 T DE69903923 T DE 69903923T DE 69903923 T DE69903923 T DE 69903923T DE 69903923 T2 DE69903923 T2 DE 69903923T2
- Authority
- DE
- Germany
- Prior art keywords
- bizyclic
- mcp
- inhibitors
- optionally substituted
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9803228.7A GB9803228D0 (en) | 1998-02-17 | 1998-02-17 | Chemical compounds |
PCT/GB1999/000335 WO1999040914A1 (en) | 1998-02-17 | 1999-02-02 | Bicyclic pyrrole derivatives as mcp-1 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69903923D1 DE69903923D1 (de) | 2002-12-19 |
DE69903923T2 true DE69903923T2 (de) | 2003-07-10 |
Family
ID=10827056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69903923T Expired - Fee Related DE69903923T2 (de) | 1998-02-17 | 1999-02-02 | Bizyklische pyrrolderivate als mcp-1 inhibitoren |
Country Status (16)
Country | Link |
---|---|
US (1) | US6479527B1 (de) |
EP (1) | EP1056451B1 (de) |
JP (1) | JP2002502874A (de) |
KR (1) | KR20010040997A (de) |
CN (1) | CN1291094A (de) |
AT (1) | ATE227570T1 (de) |
AU (1) | AU2432999A (de) |
BR (1) | BR9907936A (de) |
CA (1) | CA2319082A1 (de) |
DE (1) | DE69903923T2 (de) |
GB (1) | GB9803228D0 (de) |
IL (1) | IL137876A0 (de) |
NO (1) | NO20004091L (de) |
NZ (1) | NZ505638A (de) |
WO (1) | WO1999040914A1 (de) |
ZA (1) | ZA99940B (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB0000626D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
EP1307461A2 (de) * | 2000-08-04 | 2003-05-07 | Eli Lilly And Company | Substituierte pyrrol-verbindungen und ihre verwendung als spla2-hemmer |
US6706712B2 (en) | 2000-12-20 | 2004-03-16 | Bristol-Myers Squibb Pharma Company | Cyclic derivatives as modulators of chemokine receptor activity |
HUP0303540A2 (hu) | 2000-12-20 | 2004-01-28 | Bristol-Myers Squibb Pharma Co. | Diaminok mint kemokin receptor aktivitás modulátorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
JP2004529113A (ja) | 2001-03-07 | 2004-09-24 | ファイザー・プロダクツ・インク | ケモカイン受容体活性のモジュレーター |
US6730694B1 (en) | 2001-07-20 | 2004-05-04 | Eli Lilly And Company | sPLA2 inhibitors |
CA2463198A1 (en) * | 2001-10-03 | 2003-04-17 | Ucb, S.A. | Pyrrolidinone derivatives |
DE60305052T2 (de) | 2002-09-06 | 2006-12-21 | Janssen Pharmaceutica N.V. | Thienopyrrolyl und furanopyrrolyl verbindungen und deren verwendung als histamin h4 rezeptor liganden |
TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
WO2004071449A2 (en) | 2003-02-12 | 2004-08-26 | Bristol-Myers Squibb Company | Lactams as modulators of chemokine receptor activity |
US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
SE0302035D0 (sv) * | 2003-07-09 | 2003-07-09 | Biolipox Ab | New compound |
US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US7488747B2 (en) * | 2003-12-29 | 2009-02-10 | Sepracor Inc. | Pyrrole and pyrazole DAAO inhibitors |
US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
US8481035B2 (en) | 2004-04-27 | 2013-07-09 | Northwestern University | Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A |
CN101006054A (zh) * | 2004-06-18 | 2007-07-25 | 比奥里波克斯公司 | 用于炎症治疗的吲哚 |
ES2315877T3 (es) | 2004-06-18 | 2009-04-01 | Biolipox Ab | Indoles utiles en el tratamiento de inflamaciones. |
JP2008502672A (ja) * | 2004-06-18 | 2008-01-31 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
EA200700757A1 (ru) * | 2004-09-28 | 2007-10-26 | Янссен Фармацевтика Н.В. | Замещённые дипиперидиновые антагонисты ccr2 |
US7622583B2 (en) * | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
AU2006204750C1 (en) * | 2005-01-14 | 2012-11-01 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
WO2006077367A1 (en) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflamation |
ZA200705827B (en) | 2005-01-19 | 2008-10-29 | Biolipox Ab | Indoles useful in the treatment of inflammation |
WO2006077401A1 (en) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Pyrrolopyridines useful in the treatment of inflammation |
US20090069384A1 (en) * | 2005-01-19 | 2009-03-12 | Biolipox Ab | Thienopyrroles useful in the treatment of inflammation |
WO2006077364A1 (en) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflammation |
CA2594773A1 (en) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflammation |
AU2006264317B2 (en) | 2005-07-06 | 2012-02-23 | Sunovion Pharmaceuticals Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
ES2594156T3 (es) | 2006-01-06 | 2016-12-16 | Sunovion Pharmaceuticals Inc. | Cicloalquilaminas como inhibidores de la recaptación de monoaminas |
CN101426372A (zh) | 2006-01-06 | 2009-05-06 | 塞普拉柯公司 | 基于四氢萘酮的单胺再摄取抑制剂 |
US8097760B2 (en) | 2006-03-31 | 2012-01-17 | Sunovion Pharmacuticals Inc. | Preparation of chiral amides and amines |
CA2659060A1 (en) * | 2006-06-30 | 2008-01-10 | Sepracor Inc. | Fused heterocyclic inhibitors of d-amino acid oxidase |
US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
US20080058395A1 (en) * | 2006-06-30 | 2008-03-06 | Sepracor Inc. | Fused heterocyclic inhibitors of D-amino acid oxidase |
US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
US8519135B2 (en) * | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
US7671062B2 (en) | 2006-07-28 | 2010-03-02 | Bristol-Myers Squibb Company | Modulators of chemokine receptor activity, crystalline forms and process |
US7629351B2 (en) | 2006-07-28 | 2009-12-08 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino) pyrrolidin-1-yl)cyclohexyl)acetamide and other modulators of chemokine receptor activity, crystalline forms and process |
US7687508B2 (en) | 2006-07-28 | 2010-03-30 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
JP5306818B2 (ja) | 2006-10-18 | 2013-10-02 | 武田薬品工業株式会社 | 縮合複素環化合物 |
US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
ZA200904686B (en) * | 2007-01-18 | 2010-09-29 | Sepracor Inc | Inhibitiors of D-amino acid oxidase |
MX2009012685A (es) | 2007-05-31 | 2009-12-14 | Sepracor Inc | Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina. |
EP2175859B1 (de) * | 2007-07-12 | 2012-03-07 | ChemoCentryx, Inc. | Kondensierte heteroarylpyridyl- und phenylbenzensulfonamide als ccr2-modulatoren zur behandlung von entzündungen |
US20100120740A1 (en) * | 2008-08-07 | 2010-05-13 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
CN102149384B (zh) * | 2008-08-14 | 2014-08-20 | 南京奥昭生物科技有限公司 | 作为ep4受体拮抗剂的杂环酰胺衍生物 |
US20110034434A1 (en) * | 2009-08-07 | 2011-02-10 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
US8383812B2 (en) | 2009-10-13 | 2013-02-26 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes |
AU2017363299B2 (en) | 2016-11-23 | 2022-12-22 | Chemocentryx, Inc. | Method of treating focal segmental glomerulosclerosis |
EP4252629A3 (de) | 2016-12-07 | 2023-12-27 | Biora Therapeutics, Inc. | Verfahren, vorrichtungen und systeme zur detektion des magen-darm-trakts |
US10980739B2 (en) | 2016-12-14 | 2021-04-20 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
JP2020536919A (ja) | 2017-10-11 | 2020-12-17 | ケモセントリックス, インコーポレイテッド | Ccr2アンタゴニストによる巣状分節性糸球体硬化症の治療 |
EP3883635A1 (de) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Verfahren und vorrichtungen zur behandlung einer krankheit mit biotherapeutika |
WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2537974A1 (fr) * | 1982-12-16 | 1984-06-22 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
FR2565981B1 (fr) * | 1984-06-15 | 1986-09-19 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
US4751231A (en) | 1987-09-16 | 1988-06-14 | Merck & Co., Inc. | Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents |
WO1996018393A1 (en) * | 1994-12-13 | 1996-06-20 | Smithkline Beecham Corporation | Novel compounds |
TR199701096T1 (xx) | 1995-04-04 | 1998-02-21 | Texas Biotechnology Corporation | Tienil-, Furil-, Pirolil- ve Bifenils�lfonamidler ve Bunlar�n Endotelin Etkinli�ini D�zenleyen T�revleri. |
WO1997012613A1 (en) * | 1995-10-05 | 1997-04-10 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
WO1998006703A1 (en) * | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
-
1998
- 1998-02-17 GB GBGB9803228.7A patent/GB9803228D0/en not_active Ceased
-
1999
- 1999-02-02 CN CN99803003A patent/CN1291094A/zh active Pending
- 1999-02-02 NZ NZ505638A patent/NZ505638A/xx not_active Application Discontinuation
- 1999-02-02 KR KR1020007009018A patent/KR20010040997A/ko not_active Application Discontinuation
- 1999-02-02 CA CA002319082A patent/CA2319082A1/en not_active Abandoned
- 1999-02-02 DE DE69903923T patent/DE69903923T2/de not_active Expired - Fee Related
- 1999-02-02 AU AU24329/99A patent/AU2432999A/en not_active Abandoned
- 1999-02-02 EP EP99903810A patent/EP1056451B1/de not_active Expired - Lifetime
- 1999-02-02 JP JP2000531166A patent/JP2002502874A/ja active Pending
- 1999-02-02 IL IL13787699A patent/IL137876A0/xx unknown
- 1999-02-02 WO PCT/GB1999/000335 patent/WO1999040914A1/en not_active Application Discontinuation
- 1999-02-02 BR BR9907936-4A patent/BR9907936A/pt not_active IP Right Cessation
- 1999-02-02 AT AT99903810T patent/ATE227570T1/de not_active IP Right Cessation
- 1999-02-05 ZA ZA9900940A patent/ZA99940B/xx unknown
-
2000
- 2000-07-26 US US09/626,378 patent/US6479527B1/en not_active Expired - Fee Related
- 2000-08-16 NO NO20004091A patent/NO20004091L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2319082A1 (en) | 1999-08-19 |
ZA99940B (en) | 1999-08-17 |
NO20004091L (no) | 2000-10-16 |
WO1999040914A1 (en) | 1999-08-19 |
JP2002502874A (ja) | 2002-01-29 |
ATE227570T1 (de) | 2002-11-15 |
IL137876A0 (en) | 2001-10-31 |
US6479527B1 (en) | 2002-11-12 |
DE69903923D1 (de) | 2002-12-19 |
KR20010040997A (ko) | 2001-05-15 |
GB9803228D0 (en) | 1998-04-08 |
AU2432999A (en) | 1999-08-30 |
NZ505638A (en) | 2002-09-27 |
EP1056451A1 (de) | 2000-12-06 |
BR9907936A (pt) | 2000-10-24 |
EP1056451B1 (de) | 2002-11-13 |
CN1291094A (zh) | 2001-04-11 |
NO20004091D0 (no) | 2000-08-16 |
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