DE60113243T2 - Neue kristalline form eines pyrrolidylthiocarbapenem-derivates - Google Patents

Neue kristalline form eines pyrrolidylthiocarbapenem-derivates Download PDF

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Publication number
DE60113243T2
DE60113243T2 DE60113243T DE60113243T DE60113243T2 DE 60113243 T2 DE60113243 T2 DE 60113243T2 DE 60113243 T DE60113243 T DE 60113243T DE 60113243 T DE60113243 T DE 60113243T DE 60113243 T2 DE60113243 T2 DE 60113243T2
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Germany
Prior art keywords
crystal
type
diffraction
powder
ray diffraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE60113243T
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German (de)
English (en)
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DE60113243D1 (de
Inventor
Izumi Saitoh
Masayuki Takahira
Toshio Kawakita
Yasuyuki Yoshioka
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of DE60113243D1 publication Critical patent/DE60113243D1/de
Application granted granted Critical
Publication of DE60113243T2 publication Critical patent/DE60113243T2/de
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60113243T 2000-03-31 2001-03-30 Neue kristalline form eines pyrrolidylthiocarbapenem-derivates Expired - Lifetime DE60113243T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000099868 2000-03-31
JP2000099868 2000-03-31
PCT/JP2001/002834 WO2001072750A1 (fr) 2000-03-31 2001-03-30 Nouvelle forme cristalline d'un derive de pyrrolidylthiocarbapenem

Publications (2)

Publication Number Publication Date
DE60113243D1 DE60113243D1 (de) 2005-10-13
DE60113243T2 true DE60113243T2 (de) 2006-02-16

Family

ID=18614158

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60113243T Expired - Lifetime DE60113243T2 (de) 2000-03-31 2001-03-30 Neue kristalline form eines pyrrolidylthiocarbapenem-derivates

Country Status (17)

Country Link
US (5) US20030153191A1 (fi)
EP (1) EP1270575B1 (fi)
JP (1) JP3375084B2 (fi)
KR (1) KR100472842B1 (fi)
CN (1) CN1192030C (fi)
AT (1) ATE304014T1 (fi)
AU (2) AU2001244692B2 (fi)
BR (1) BRPI0109712B8 (fi)
CA (1) CA2404703C (fi)
CY (2) CY1105674T1 (fi)
DE (1) DE60113243T2 (fi)
DK (1) DK1270575T3 (fi)
ES (1) ES2252205T3 (fi)
MX (1) MXPA02009592A (fi)
TW (1) TWI293631B (fi)
WO (1) WO2001072750A1 (fi)
ZA (1) ZA200207675B (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1270575B1 (en) * 2000-03-31 2005-09-07 Shionogi & Co., Ltd. Novel crystal form of pyrrolidylthiocarbapenem derivative
JP5004355B2 (ja) * 2001-05-10 2012-08-22 塩野義製薬株式会社 アセチルチオピロリジン誘導体の製法
JP2005509037A (ja) * 2001-11-16 2005-04-07 ランバクシー ラボラトリーズ リミテッド 結晶イミペネム製造方法
TWI353855B (en) * 2005-05-26 2011-12-11 Shionogi & Co Method for preparing an aqueous solution of doripe
WO2007125788A1 (ja) * 2006-04-28 2007-11-08 Kaneka Corporation カルバペネム抗生物質中間体の改良された晶析方法
WO2008006298A1 (fr) * 2006-07-03 2008-01-17 Chengdu Di'ao Jiuhong Pharmaceutical Factory Nouvelle forme cristalline de doripenem, préparation, procédé et utilisations de celle-ci
CN101191787B (zh) * 2006-11-21 2011-07-27 上海医药工业研究院 高效液相色谱法测定多利培南含量的方法
PL2276762T3 (pl) * 2008-03-24 2015-06-30 Ranbaxy Laboratories Ltd Sposób wytwarzania jałowego doripenemu
WO2011150679A1 (zh) * 2010-06-03 2011-12-08 山东轩竹医药科技有限公司 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途
CN102977101A (zh) * 2011-09-07 2013-03-20 中国人民解放军军事医学科学院毒物药物研究所 多尼培南一水合物、其药物组合物、其制备方法和用途
CN102285988B (zh) * 2011-09-08 2012-09-05 上海希迈医药科技有限公司 一种多尼培南水合物晶体及其制备方法
EP2776440A1 (en) * 2011-11-08 2014-09-17 Ranbaxy Laboratories Limited Process for the preparation of polymorphs of doripenem
CN104072497B (zh) * 2013-03-29 2017-10-03 石药集团中奇制药技术（石家庄）有限公司 一种多尼培南新结晶及其制备方法
CN103389347B (zh) * 2013-07-26 2015-12-09 深圳市海滨制药有限公司 高效液相色谱法测定多尼培南的方法
KR101910048B1 (ko) 2014-04-28 2018-10-22 제이더블유중외제약 주식회사 도리페넴의 신규한 결정 및 이의 제조방법
KR20160007679A (ko) 2016-01-04 2016-01-20 제일약품주식회사 도리페넴의 신규한 결정형

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317016A (en) 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
US5539102A (en) * 1992-02-21 1996-07-23 Shionogi Seiyaku Kabushiki Kaisha Production method for sulfamide
US6111098A (en) * 1994-05-02 2000-08-29 Shionogi & Co., Ltd. Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same
JP3558684B2 (ja) * 1994-06-28 2004-08-25 塩野義製薬株式会社 ピロリジルチオカルバペネム誘導体の乾燥方法
EP1270575B1 (en) * 2000-03-31 2005-09-07 Shionogi & Co., Ltd. Novel crystal form of pyrrolidylthiocarbapenem derivative
WO2004072073A1 (ja) * 2003-02-14 2004-08-26 Shionogi & Co., Ltd. カルバペネム合成中間体の結晶
WO2010097686A1 (en) 2009-02-26 2010-09-02 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of carbapenem antibiotic

Also Published As

Publication number Publication date
AU4469201A (en) 2001-10-08
DE60113243D1 (de) 2005-10-13
US8247402B2 (en) 2012-08-21
JP3375084B2 (ja) 2003-02-10
US20150031664A1 (en) 2015-01-29
KR20020087446A (ko) 2002-11-22
US20080207586A1 (en) 2008-08-28
CY2009001I1 (el) 2009-11-04
AU2001244692B2 (en) 2004-10-14
KR100472842B1 (ko) 2005-03-10
BRPI0109712B8 (pt) 2021-05-25
CN1192030C (zh) 2005-03-09
DK1270575T3 (da) 2006-01-16
US20030153191A1 (en) 2003-08-14
ZA200207675B (en) 2003-09-25
US9221823B2 (en) 2015-12-29
ATE304014T1 (de) 2005-09-15
CN1432016A (zh) 2003-07-23
TWI293631B (fi) 2008-02-21
EP1270575B1 (en) 2005-09-07
CY2009001I2 (el) 2009-11-04
EP1270575A4 (en) 2004-02-18
MXPA02009592A (es) 2003-03-12
BR0109712A (pt) 2003-04-29
CA2404703A1 (en) 2002-09-26
US20130059831A1 (en) 2013-03-07
US20070060562A1 (en) 2007-03-15
BRPI0109712B1 (pt) 2017-10-24
WO2001072750A1 (fr) 2001-10-04
CA2404703C (en) 2007-06-05
CY1105674T1 (el) 2010-07-28
ES2252205T3 (es) 2006-05-16
EP1270575A1 (en) 2003-01-02

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