CY1105674T1 - Νεα μορφη κρυσταλλου του παραγωγου πυρρολιδυλοθειοκαρβαπενεμης - Google Patents

Νεα μορφη κρυσταλλου του παραγωγου πυρρολιδυλοθειοκαρβαπενεμης

Info

Publication number
CY1105674T1
CY1105674T1 CY20051101453T CY051101453T CY1105674T1 CY 1105674 T1 CY1105674 T1 CY 1105674T1 CY 20051101453 T CY20051101453 T CY 20051101453T CY 051101453 T CY051101453 T CY 051101453T CY 1105674 T1 CY1105674 T1 CY 1105674T1
Authority
CY
Cyprus
Prior art keywords
new crystal
crystal form
derivative
pyrrolidylthiocarbapenem derivative
crystal
Prior art date
Application number
CY20051101453T
Other languages
English (en)
Inventor
Izumi Saitoh
Masayuki Takahira
Toshio Kawakita
Yasuyuki Yoshioka
Original Assignee
Shionogi & Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18614158&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1105674(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co., Ltd filed Critical Shionogi & Co., Ltd
Publication of CY1105674T1 publication Critical patent/CY1105674T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Παρέχεται ένα νέο κρύσταλλο ενός παραγώγου πυρρολιδυλο-θειοκαρβαπενέμης που έχει εξαιρετική σταθερότητα. Σύμφωνα με την παρούσα εφεύρεση παρέχεται ένα κρύσταλλο του (+)-(4R,5S,6S)-6-[(1R)-1-υδροξυαιθυλ]-4-μεθυλ-7-οξο-3[[(3S,5S)-5-(σουλφαμοϋλαμινομεθυλ)πυρρολιδιν-3-υλ]θειο]-1-αζαδικυκλο-[3.2.0]επτ-2-ενο-2-καρβοξυλικού οξέος που έχει μία εικόνα περίθλασης σε περίθλαση ακτίνων-Χ κρυσταλλικής κόνεως που κατά προτίμηση έχει κύριες κορυφές σε γωνίες περίθλασης (2Θ) = 13,04, 14,98, 15,88, 16,62, 20,62, 21,06, 22,18, 23,90, 26,08, 28,22 και 28,98 (μοίρες).
CY20051101453T 2000-03-31 2005-11-28 Νεα μορφη κρυσταλλου του παραγωγου πυρρολιδυλοθειοκαρβαπενεμης CY1105674T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000099868 2000-03-31
PCT/JP2001/002834 WO2001072750A1 (fr) 2000-03-31 2001-03-30 Nouvelle forme cristalline d'un derive de pyrrolidylthiocarbapenem

Publications (1)

Publication Number Publication Date
CY1105674T1 true CY1105674T1 (el) 2010-07-28

Family

ID=18614158

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20051101453T CY1105674T1 (el) 2000-03-31 2005-11-28 Νεα μορφη κρυσταλλου του παραγωγου πυρρολιδυλοθειοκαρβαπενεμης
CY200900001C CY2009001I2 (el) 2000-03-31 2009-01-23 Νεα μορφη κρυσταλλου του παραγωγου πυρρολιδυλοθειοκαρβαπενεμης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY200900001C CY2009001I2 (el) 2000-03-31 2009-01-23 Νεα μορφη κρυσταλλου του παραγωγου πυρρολιδυλοθειοκαρβαπενεμης

Country Status (17)

Country Link
US (5) US20030153191A1 (el)
EP (1) EP1270575B1 (el)
JP (1) JP3375084B2 (el)
KR (1) KR100472842B1 (el)
CN (1) CN1192030C (el)
AT (1) ATE304014T1 (el)
AU (2) AU4469201A (el)
BR (1) BRPI0109712B8 (el)
CA (1) CA2404703C (el)
CY (2) CY1105674T1 (el)
DE (1) DE60113243T2 (el)
DK (1) DK1270575T3 (el)
ES (1) ES2252205T3 (el)
MX (1) MXPA02009592A (el)
TW (1) TWI293631B (el)
WO (1) WO2001072750A1 (el)
ZA (1) ZA200207675B (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI293631B (el) * 2000-03-31 2008-02-21 Shionogi & Co
JP5004355B2 (ja) * 2001-05-10 2012-08-22 塩野義製薬株式会社 アセチルチオピロリジン誘導体の製法
EP1448563A1 (en) * 2001-11-16 2004-08-25 Ranbaxy Laboratories, Ltd. Process for the preparation of crystalline imipenem
TWI353855B (en) 2005-05-26 2011-12-11 Shionogi & Co Method for preparing an aqueous solution of doripe
KR20090007572A (ko) * 2006-04-28 2009-01-19 카네카 코포레이션 카르바페넴 항생 물질 중간체의 개량된 정석 방법
CN101466713A (zh) * 2006-07-03 2009-06-24 成都地奥九泓制药厂 多尼培南的新结晶及其制备方法和用途
CN101191787B (zh) * 2006-11-21 2011-07-27 上海医药工业研究院 高效液相色谱法测定多利培南含量的方法
EP2276762B1 (en) 2008-03-24 2014-10-01 Ranbaxy Laboratories Limited Process for the preparation of sterile doripenem
US8822445B2 (en) 2010-06-03 2014-09-02 Xuanzhu Pharma Co., Ltd. Crystalline form of carbapenem derivative or its hydrates and preparation methods and uses thereof
CN102977101A (zh) * 2011-09-07 2013-03-20 中国人民解放军军事医学科学院毒物药物研究所 多尼培南一水合物、其药物组合物、其制备方法和用途
CN102285988B (zh) * 2011-09-08 2012-09-05 上海希迈医药科技有限公司 一种多尼培南水合物晶体及其制备方法
EP2776440A1 (en) * 2011-11-08 2014-09-17 Ranbaxy Laboratories Limited Process for the preparation of polymorphs of doripenem
CN104072497B (zh) * 2013-03-29 2017-10-03 石药集团中奇制药技术（石家庄）有限公司 一种多尼培南新结晶及其制备方法
CN103389347B (zh) * 2013-07-26 2015-12-09 深圳市海滨制药有限公司 高效液相色谱法测定多尼培南的方法
US9840506B2 (en) 2014-04-28 2017-12-12 Jw Pharmaceutical Corporation Crystal of doripenem, and preparation method therefor
KR20160007679A (ko) 2016-01-04 2016-01-20 제일약품주식회사 도리페넴의 신규한 결정형

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
US5539102A (en) * 1992-02-21 1996-07-23 Shionogi Seiyaku Kabushiki Kaisha Production method for sulfamide
AU700545B2 (en) * 1994-05-02 1999-01-07 Shionogi & Co., Ltd. Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same
JP3558684B2 (ja) * 1994-06-28 2004-08-25 塩野義製薬株式会社 ピロリジルチオカルバペネム誘導体の乾燥方法
TWI293631B (el) * 2000-03-31 2008-02-21 Shionogi & Co
KR101089529B1 (ko) * 2003-02-14 2011-12-05 시오노기세이야쿠가부시키가이샤 카르바페넴 중간체의 결정
EP2401278A4 (en) 2009-02-26 2012-07-04 Orchid Chemicals & Pharm Ltd IMPROVED PROCESS FOR THE PREPARATION OF A CARBAPENEM ANTIBIOTICS

Also Published As

Publication number Publication date
DK1270575T3 (da) 2006-01-16
CN1432016A (zh) 2003-07-23
US8247402B2 (en) 2012-08-21
KR100472842B1 (ko) 2005-03-10
ES2252205T3 (es) 2006-05-16
EP1270575A4 (en) 2004-02-18
US20150031664A1 (en) 2015-01-29
CY2009001I1 (el) 2009-11-04
CA2404703A1 (en) 2002-09-26
WO2001072750A1 (fr) 2001-10-04
US20080207586A1 (en) 2008-08-28
US20070060562A1 (en) 2007-03-15
EP1270575A1 (en) 2003-01-02
JP3375084B2 (ja) 2003-02-10
AU4469201A (en) 2001-10-08
CA2404703C (en) 2007-06-05
DE60113243D1 (de) 2005-10-13
ATE304014T1 (de) 2005-09-15
CN1192030C (zh) 2005-03-09
BR0109712A (pt) 2003-04-29
DE60113243T2 (de) 2006-02-16
US20030153191A1 (en) 2003-08-14
ZA200207675B (en) 2003-09-25
AU2001244692B2 (en) 2004-10-14
US9221823B2 (en) 2015-12-29
BRPI0109712B8 (pt) 2021-05-25
KR20020087446A (ko) 2002-11-22
US20130059831A1 (en) 2013-03-07
TWI293631B (el) 2008-02-21
BRPI0109712B1 (pt) 2017-10-24
MXPA02009592A (es) 2003-03-12
CY2009001I2 (el) 2009-11-04
EP1270575B1 (en) 2005-09-07

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