DE60014088D1 - Verfahren zur herstellung von (nitroxymethyl)phenylestern von salicylsäurederivaten - Google Patents
Verfahren zur herstellung von (nitroxymethyl)phenylestern von salicylsäurederivatenInfo
- Publication number
- DE60014088D1 DE60014088D1 DE60014088T DE60014088T DE60014088D1 DE 60014088 D1 DE60014088 D1 DE 60014088D1 DE 60014088 T DE60014088 T DE 60014088T DE 60014088 T DE60014088 T DE 60014088T DE 60014088 D1 DE60014088 D1 DE 60014088D1
- Authority
- DE
- Germany
- Prior art keywords
- salicylic acid
- nitroxymethyl
- acid derivatives
- phenyl esters
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI991517 | 1999-07-09 | ||
IT1999MI001517A ITMI991517A1 (it) | 1999-07-09 | 1999-07-09 | Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico |
PCT/EP2000/005722 WO2001004082A1 (en) | 1999-07-09 | 2000-06-21 | A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60014088D1 true DE60014088D1 (de) | 2004-10-28 |
DE60014088T2 DE60014088T2 (de) | 2005-10-06 |
Family
ID=11383309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60014088T Expired - Fee Related DE60014088T2 (de) | 1999-07-09 | 2000-06-21 | Verfahren zur herstellung von (nitroxymethyl)phenylestern von salicylsäurederivaten |
Country Status (25)
Country | Link |
---|---|
US (1) | US6696591B1 (de) |
EP (1) | EP1194397B1 (de) |
JP (1) | JP2003504352A (de) |
KR (1) | KR100671996B1 (de) |
CN (1) | CN1165511C (de) |
AT (1) | ATE276998T1 (de) |
AU (1) | AU775482B2 (de) |
BR (1) | BR0012168A (de) |
CA (1) | CA2377222A1 (de) |
DE (1) | DE60014088T2 (de) |
DK (1) | DK1194397T3 (de) |
ES (1) | ES2228551T3 (de) |
HU (1) | HUP0201766A3 (de) |
IL (1) | IL147054A0 (de) |
IT (1) | ITMI991517A1 (de) |
MX (1) | MXPA02000245A (de) |
NO (1) | NO20020052D0 (de) |
NZ (1) | NZ516125A (de) |
PL (1) | PL193252B1 (de) |
PT (1) | PT1194397E (de) |
RU (1) | RU2235717C2 (de) |
SI (1) | SI1194397T1 (de) |
TR (1) | TR200200010T2 (de) |
WO (1) | WO2001004082A1 (de) |
ZA (1) | ZA200110276B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1319202B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
US6706724B2 (en) | 2000-12-21 | 2004-03-16 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
US7220749B2 (en) | 2002-06-11 | 2007-05-22 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
JP2005539089A (ja) | 2002-07-03 | 2005-12-22 | ニトロメッド インコーポレーティッド | ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法 |
CA2493156A1 (en) | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
EP1789091B1 (de) | 2004-08-26 | 2010-08-25 | Piramal Life Sciences Limited | Prodrugs mit neuen biospaltbaren verbindern |
TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
PT1978947E (pt) | 2006-02-03 | 2014-11-03 | Nicox Science Ireland | Derivados nitro-óxido para utilização no tratamento de distrofias musculares |
EP2048129A1 (de) * | 2007-10-12 | 2009-04-15 | Lonza Ag | Verfahren zur Herstellung organischer Nitrate |
CN101973879B (zh) * | 2010-09-27 | 2013-03-13 | 广安凯特医药化工有限公司 | 一种吉法酯的制备方法 |
CA2925293C (en) | 2013-09-24 | 2023-05-16 | Universitat Zu Koln | Compounds useful in the treatment of neoplastic diseases |
ES2837835T3 (es) * | 2014-02-24 | 2021-07-01 | Natureworks Llc | Procedimiento para preparar un éster 2-acetoxialcanoico |
WO2015127372A1 (en) * | 2014-02-24 | 2015-08-27 | Nature Works Llc | Process for making esters of 2-acetoxyalkanoic acids using an alpha-hydroxyalkanoic acid ester and an acetate ester as starting materials |
CN107074716A (zh) * | 2014-07-18 | 2017-08-18 | 比奥考金特有限责任公司 | 包含水杨酸酯和聚水杨酸酯的组合物及方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1243367B (it) * | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
JP3646223B2 (ja) * | 1992-06-16 | 2005-05-11 | 日本農薬株式会社 | 求電子反応による芳香族化合物の製造方法及び芳香族化合物 |
US5700947A (en) * | 1993-10-06 | 1997-12-23 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
FR2724378B1 (fr) * | 1994-09-09 | 1996-12-20 | Rhone Poulenc Chimie | Procede de preparation de l'acide picrique |
DE19515970A1 (de) * | 1995-05-02 | 1996-11-07 | Bayer Ag | Acetylsalicylsäurenitrate |
IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
IT1307928B1 (it) | 1999-01-26 | 2001-11-29 | Nicox Sa | Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina. |
-
1999
- 1999-07-09 IT IT1999MI001517A patent/ITMI991517A1/it unknown
-
2000
- 2000-06-21 CN CNB008100225A patent/CN1165511C/zh not_active Expired - Fee Related
- 2000-06-21 TR TR2002/00010T patent/TR200200010T2/xx unknown
- 2000-06-21 HU HU0201766A patent/HUP0201766A3/hu unknown
- 2000-06-21 AU AU56845/00A patent/AU775482B2/en not_active Ceased
- 2000-06-21 NZ NZ516125A patent/NZ516125A/en unknown
- 2000-06-21 PL PL352359A patent/PL193252B1/pl unknown
- 2000-06-21 AT AT00942111T patent/ATE276998T1/de not_active IP Right Cessation
- 2000-06-21 IL IL14705400A patent/IL147054A0/xx not_active IP Right Cessation
- 2000-06-21 SI SI200030541T patent/SI1194397T1/xx unknown
- 2000-06-21 DK DK00942111T patent/DK1194397T3/da active
- 2000-06-21 BR BR0012168-1A patent/BR0012168A/pt not_active Application Discontinuation
- 2000-06-21 US US10/019,316 patent/US6696591B1/en not_active Expired - Fee Related
- 2000-06-21 DE DE60014088T patent/DE60014088T2/de not_active Expired - Fee Related
- 2000-06-21 RU RU2002100083/04A patent/RU2235717C2/ru not_active IP Right Cessation
- 2000-06-21 CA CA002377222A patent/CA2377222A1/en not_active Abandoned
- 2000-06-21 WO PCT/EP2000/005722 patent/WO2001004082A1/en active IP Right Grant
- 2000-06-21 ES ES00942111T patent/ES2228551T3/es not_active Expired - Lifetime
- 2000-06-21 EP EP00942111A patent/EP1194397B1/de not_active Expired - Lifetime
- 2000-06-21 PT PT00942111T patent/PT1194397E/pt unknown
- 2000-06-21 MX MXPA02000245A patent/MXPA02000245A/es active IP Right Grant
- 2000-06-21 JP JP2001509694A patent/JP2003504352A/ja active Pending
- 2000-06-21 KR KR1020027000057A patent/KR100671996B1/ko not_active IP Right Cessation
-
2001
- 2001-12-13 ZA ZA200110276A patent/ZA200110276B/xx unknown
-
2002
- 2002-01-07 NO NO20020052A patent/NO20020052D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
ES2228551T3 (es) | 2005-04-16 |
KR20020024298A (ko) | 2002-03-29 |
DK1194397T3 (da) | 2005-01-31 |
PT1194397E (pt) | 2005-02-28 |
CN1165511C (zh) | 2004-09-08 |
PL193252B1 (pl) | 2007-01-31 |
EP1194397B1 (de) | 2004-09-22 |
US6696591B1 (en) | 2004-02-24 |
BR0012168A (pt) | 2002-03-19 |
AU5684500A (en) | 2001-01-30 |
HUP0201766A2 (en) | 2002-10-28 |
CN1360566A (zh) | 2002-07-24 |
NO20020052L (no) | 2002-01-07 |
ZA200110276B (en) | 2003-05-28 |
MXPA02000245A (es) | 2004-09-10 |
CA2377222A1 (en) | 2001-01-18 |
RU2235717C2 (ru) | 2004-09-10 |
ATE276998T1 (de) | 2004-10-15 |
PL352359A1 (en) | 2003-08-11 |
KR100671996B1 (ko) | 2007-01-19 |
IL147054A0 (en) | 2002-08-14 |
WO2001004082A1 (en) | 2001-01-18 |
DE60014088T2 (de) | 2005-10-06 |
JP2003504352A (ja) | 2003-02-04 |
HUP0201766A3 (en) | 2003-08-28 |
EP1194397A1 (de) | 2002-04-10 |
SI1194397T1 (en) | 2005-02-28 |
NO20020052D0 (no) | 2002-01-07 |
TR200200010T2 (tr) | 2002-09-23 |
ITMI991517A1 (it) | 2001-01-09 |
AU775482B2 (en) | 2004-08-05 |
NZ516125A (en) | 2004-06-25 |
ITMI991517A0 (it) | 1999-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NICOX S.A., SOPHIA ANTIPOLIS, FR |
|
8339 | Ceased/non-payment of the annual fee |