DK1194397T3 - Fremgangsmåde til fremstilling af (nitroxymethyl)phenylestere af salicylderivater - Google Patents

Fremgangsmåde til fremstilling af (nitroxymethyl)phenylestere af salicylderivater

Info

Publication number
DK1194397T3
DK1194397T3 DK00942111T DK00942111T DK1194397T3 DK 1194397 T3 DK1194397 T3 DK 1194397T3 DK 00942111 T DK00942111 T DK 00942111T DK 00942111 T DK00942111 T DK 00942111T DK 1194397 T3 DK1194397 T3 DK 1194397T3
Authority
DK
Denmark
Prior art keywords
nitroxymethyl
phenyl esters
preparation
acid
derivatives
Prior art date
Application number
DK00942111T
Other languages
English (en)
Inventor
Graziano Castaldi
Francesca Benedini
Erminio Oldani
Gabriele Razzetti
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of DK1194397T3 publication Critical patent/DK1194397T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK00942111T 1999-07-09 2000-06-21 Fremgangsmåde til fremstilling af (nitroxymethyl)phenylestere af salicylderivater DK1194397T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999MI001517A ITMI991517A1 (it) 1999-07-09 1999-07-09 Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
PCT/EP2000/005722 WO2001004082A1 (en) 1999-07-09 2000-06-21 A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives
EP00942111A EP1194397B1 (en) 1999-07-09 2000-06-21 A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives

Publications (1)

Publication Number Publication Date
DK1194397T3 true DK1194397T3 (da) 2005-01-31

Family

ID=11383309

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00942111T DK1194397T3 (da) 1999-07-09 2000-06-21 Fremgangsmåde til fremstilling af (nitroxymethyl)phenylestere af salicylderivater

Country Status (25)

Country Link
US (1) US6696591B1 (da)
EP (1) EP1194397B1 (da)
JP (1) JP2003504352A (da)
KR (1) KR100671996B1 (da)
CN (1) CN1165511C (da)
AT (1) ATE276998T1 (da)
AU (1) AU775482B2 (da)
BR (1) BR0012168A (da)
CA (1) CA2377222A1 (da)
DE (1) DE60014088T2 (da)
DK (1) DK1194397T3 (da)
ES (1) ES2228551T3 (da)
HU (1) HUP0201766A3 (da)
IL (1) IL147054A0 (da)
IT (1) ITMI991517A1 (da)
MX (1) MXPA02000245A (da)
NO (1) NO20020052D0 (da)
NZ (1) NZ516125A (da)
PL (1) PL193252B1 (da)
PT (1) PT1194397E (da)
RU (1) RU2235717C2 (da)
SI (1) SI1194397T1 (da)
TR (1) TR200200010T2 (da)
WO (1) WO2001004082A1 (da)
ZA (1) ZA200110276B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
CA2432642A1 (en) 2000-12-21 2002-08-08 Subhash P. Khanapure Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2006501161A (ja) 2002-06-11 2006-01-12 ニトロメッド インク． ニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物ならびに使用方法
JP2005539089A (ja) 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
CA2493156A1 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
KR20070053214A (ko) 2004-08-26 2007-05-23 니콜라스 피라말 인디아 리미티드 신규 생분해성 링커를 함유하는 프로드럭
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
DK1978947T3 (da) 2006-02-03 2014-11-03 Nicox Science Ireland Nitrooxyderivater til anvendelse ved behandling af muskeldystrofier
EP2048129A1 (en) * 2007-10-12 2009-04-15 Lonza Ag Method for the preparation of organic nitrates
CN101973879B (zh) * 2010-09-27 2013-03-13 广安凯特医药化工有限公司 一种吉法酯的制备方法
WO2015044177A1 (en) 2013-09-24 2015-04-02 Universität Zu Köln Compounds useful in the treatment of neoplastic diseases
RU2710547C2 (ru) * 2014-02-24 2019-12-27 НЕЙЧЕРВОРКС ЭлЭлСи Способ получения сложных эфиров 2-ацетоксиалкановых кислот с использованием сложного эфира альфа-гидроксиалкановой кислоты и сложного эфира уксусной кислоты в качестве исходных веществ
EP3110787B1 (en) * 2014-02-24 2018-04-11 NatureWorks LLC Process for making esters of 2-acetoxyalkanoic acids using a 3,6-dialkyl-1,4-dioxane-2,5-dione or poly-(alpha-hydroxyalkanoic acid) as a starting material
US20170158599A1 (en) * 2014-07-18 2017-06-08 Joseph D. Ceccoli Compositions and methods comprising salicylates and polysalicylates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
JP3646223B2 (ja) * 1992-06-16 2005-05-11 日本農薬株式会社 求電子反応による芳香族化合物の製造方法及び芳香族化合物
EP0722434B1 (en) * 1993-10-06 1998-07-29 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
FR2724378B1 (fr) * 1994-09-09 1996-12-20 Rhone Poulenc Chimie Procede de preparation de l'acide picrique
DE19515970A1 (de) * 1995-05-02 1996-11-07 Bayer Ag Acetylsalicylsäurenitrate
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
IT1307928B1 (it) 1999-01-26 2001-11-29 Nicox Sa Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.

Also Published As

Publication number Publication date
MXPA02000245A (es) 2004-09-10
ES2228551T3 (es) 2005-04-16
PL193252B1 (pl) 2007-01-31
PL352359A1 (en) 2003-08-11
ITMI991517A1 (it) 2001-01-09
CN1165511C (zh) 2004-09-08
ATE276998T1 (de) 2004-10-15
NZ516125A (en) 2004-06-25
EP1194397B1 (en) 2004-09-22
KR100671996B1 (ko) 2007-01-19
RU2235717C2 (ru) 2004-09-10
DE60014088T2 (de) 2005-10-06
ZA200110276B (en) 2003-05-28
NO20020052L (no) 2002-01-07
US6696591B1 (en) 2004-02-24
SI1194397T1 (en) 2005-02-28
NO20020052D0 (no) 2002-01-07
AU775482B2 (en) 2004-08-05
TR200200010T2 (tr) 2002-09-23
CN1360566A (zh) 2002-07-24
KR20020024298A (ko) 2002-03-29
HUP0201766A2 (en) 2002-10-28
ITMI991517A0 (it) 1999-07-09
WO2001004082A1 (en) 2001-01-18
JP2003504352A (ja) 2003-02-04
AU5684500A (en) 2001-01-30
DE60014088D1 (de) 2004-10-28
CA2377222A1 (en) 2001-01-18
BR0012168A (pt) 2002-03-19
IL147054A0 (en) 2002-08-14
HUP0201766A3 (en) 2003-08-28
PT1194397E (pt) 2005-02-28
EP1194397A1 (en) 2002-04-10

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