ATE288441T1 - Beta-ketophosphonaten - Google Patents
Beta-ketophosphonatenInfo
- Publication number
- ATE288441T1 ATE288441T1 AT02755252T AT02755252T ATE288441T1 AT E288441 T1 ATE288441 T1 AT E288441T1 AT 02755252 T AT02755252 T AT 02755252T AT 02755252 T AT02755252 T AT 02755252T AT E288441 T1 ATE288441 T1 AT E288441T1
- Authority
- AT
- Austria
- Prior art keywords
- ketophosphonates
- followed
- beta
- reaction
- purification
- Prior art date
Links
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 abstract 1
- 239000012346 acetyl chloride Substances 0.000 abstract 1
- 150000001266 acyl halides Chemical class 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- GGUBFICZYGKNTD-UHFFFAOYSA-N triethyl phosphonoacetate Chemical compound CCOC(=O)CP(=O)(OCC)OCC GGUBFICZYGKNTD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0123202.4A GB0123202D0 (en) | 2001-09-27 | 2001-09-27 | Beta-ketophosphonates |
| PCT/GB2002/003922 WO2003027129A1 (en) | 2001-09-27 | 2002-08-23 | Beta-ketophosphonates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288441T1 true ATE288441T1 (de) | 2005-02-15 |
Family
ID=9922770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02755252T ATE288441T1 (de) | 2001-09-27 | 2002-08-23 | Beta-ketophosphonaten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7112692B2 (de) |
| EP (1) | EP1430065B1 (de) |
| JP (1) | JP4399262B2 (de) |
| AT (1) | ATE288441T1 (de) |
| CA (1) | CA2463287C (de) |
| DE (1) | DE60202884T2 (de) |
| ES (1) | ES2236554T3 (de) |
| GB (1) | GB0123202D0 (de) |
| WO (1) | WO2003027129A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
| US20070021612A1 (en) * | 2004-11-04 | 2007-01-25 | University Of Notre Dame Du Lac | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof |
| CN104341449A (zh) * | 2014-09-30 | 2015-02-11 | 苏州大学 | 一种β-羰基膦酸酯衍生物的制备方法 |
| CN105330690B (zh) * | 2015-10-19 | 2017-03-29 | 深圳瑞科生物科技有限公司 | 一种药物中间体芳基酮膦酸酯化合物的合成方法 |
-
2001
- 2001-09-27 GB GBGB0123202.4A patent/GB0123202D0/en not_active Ceased
-
2002
- 2002-08-23 EP EP02755252A patent/EP1430065B1/de not_active Expired - Lifetime
- 2002-08-23 WO PCT/GB2002/003922 patent/WO2003027129A1/en active IP Right Grant
- 2002-08-23 ES ES02755252T patent/ES2236554T3/es not_active Expired - Lifetime
- 2002-08-23 CA CA002463287A patent/CA2463287C/en not_active Expired - Fee Related
- 2002-08-23 DE DE60202884T patent/DE60202884T2/de not_active Expired - Lifetime
- 2002-08-23 JP JP2003530716A patent/JP4399262B2/ja not_active Expired - Fee Related
- 2002-08-23 US US10/485,899 patent/US7112692B2/en not_active Expired - Lifetime
- 2002-08-23 AT AT02755252T patent/ATE288441T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2463287C (en) | 2009-12-15 |
| US7112692B2 (en) | 2006-09-26 |
| DE60202884T2 (de) | 2005-10-27 |
| EP1430065B1 (de) | 2005-02-02 |
| US20040267040A1 (en) | 2004-12-30 |
| GB0123202D0 (en) | 2001-11-21 |
| JP4399262B2 (ja) | 2010-01-13 |
| ES2236554T3 (es) | 2005-07-16 |
| CA2463287A1 (en) | 2003-04-03 |
| WO2003027129A1 (en) | 2003-04-03 |
| DE60202884D1 (de) | 2005-03-10 |
| EP1430065A1 (de) | 2004-06-23 |
| JP2005503443A (ja) | 2005-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |