ATE539071T1 - Verfahren zur herstellung von s-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-ca bonsäure - Google Patents

Verfahren zur herstellung von s-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-ca bonsäure

Info

Publication number
ATE539071T1
ATE539071T1 AT07830535T AT07830535T ATE539071T1 AT E539071 T1 ATE539071 T1 AT E539071T1 AT 07830535 T AT07830535 T AT 07830535T AT 07830535 T AT07830535 T AT 07830535T AT E539071 T1 ATE539071 T1 AT E539071T1
Authority
AT
Austria
Prior art keywords
tetramethylchromane
hydroxy
carboxylic acid
general formula
producing
Prior art date
Application number
AT07830535T
Other languages
English (en)
Inventor
Akifumi Iida
Youichi Kyuuko
Toshio Hidaka
Original Assignee
Mitsubishi Gas Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Gas Chemical Co filed Critical Mitsubishi Gas Chemical Co
Application granted granted Critical
Publication of ATE539071T1 publication Critical patent/ATE539071T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
AT07830535T 2006-10-26 2007-10-25 Verfahren zur herstellung von s-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-ca bonsäure ATE539071T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006291628 2006-10-26
PCT/JP2007/070801 WO2008050829A1 (fr) 2006-10-26 2007-10-25 Procédé de fabrication de l'acide s -(-)-6-hydroxy-2,5,7,8-tétraméthylchromane-2-carboxylique et produit obtenu par le procédé

Publications (1)

Publication Number Publication Date
ATE539071T1 true ATE539071T1 (de) 2012-01-15

Family

ID=39324614

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07830535T ATE539071T1 (de) 2006-10-26 2007-10-25 Verfahren zur herstellung von s-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-ca bonsäure

Country Status (5)

Country Link
US (1) US8080676B2 (de)
EP (1) EP2088144B1 (de)
JP (1) JPWO2008050829A1 (de)
AT (1) ATE539071T1 (de)
WO (1) WO2008050829A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE028502T2 (en) 2007-11-06 2016-12-28 Edison Pharmaceuticals Inc 4- (P-Quinonyl) -2-hydroxybutanamide derivatives for the treatment of mitochondrial diseases
CN102203047B (zh) * 2008-10-29 2013-12-11 三菱瓦斯化学株式会社 光学活性有机羧酸的制造方法
JP2018500317A (ja) * 2014-12-16 2018-01-11 バイオエレクトロン テクノロジー コーポレイション トロロックスのキラル分割のための方法
SG10202003299PA (en) 2014-12-16 2020-05-28 Ptc Therapeutics Inc Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026907A (en) * 1973-11-19 1977-05-31 Hoffmann-La Roche Inc. Antioxidant chroman compounds
JPS6092283A (ja) 1983-10-27 1985-05-23 Nippon Oil Co Ltd クロマン化合物の選択的合成法
US5348973A (en) 1990-10-09 1994-09-20 Rhone-Poulenc Chimie Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis
JP3400039B2 (ja) 1993-09-28 2003-04-28 株式会社クラレ クロマン化合物の製造方法
JP3913329B2 (ja) 1997-09-11 2007-05-09 株式会社クラレ （±）−クロマンカルボン酸の光学分割法
WO2002012221A1 (fr) 2000-08-03 2002-02-14 Kuraray Co., Ltd. Procede de resolution optique de l'acide (±)-6-hydroxy-2,5,7,8,-tetramethyle de coumarone-2-carboxylique
JP2003146981A (ja) 2001-11-14 2003-05-21 Mitsubishi Gas Chem Co Inc ６−ヒドロキシ−２，５，７，８−テトラメチルクロマン−２−カルボン酸エステルの製造方法
WO2004108944A1 (ja) * 2003-06-04 2004-12-16 Mitsubishi Gas Chemical Company, Inc. 光学活性クロマンカルボン酸エステルの製造方法
US7615650B2 (en) * 2004-01-30 2009-11-10 Mitsubishi Gas Chemical Company, Inc. Process for producing chroman compound
JP4826132B2 (ja) * 2005-04-28 2011-11-30 三菱瓦斯化学株式会社 ６−ヒドロキシ−２，５，７，８−テトラメチルクロマン−２−カルボン酸及びその製造方法
JP4826133B2 (ja) * 2005-04-28 2011-11-30 三菱瓦斯化学株式会社 Ｓ−（−）−６−ヒドロキシ−２，５，７，８−テトラメチルクロマン−２−カルボン酸及びその製造方法

Also Published As

Publication number Publication date
EP2088144A4 (de) 2010-01-27
EP2088144A1 (de) 2009-08-12
US20100063305A1 (en) 2010-03-11
WO2008050829A1 (fr) 2008-05-02
US8080676B2 (en) 2011-12-20
JPWO2008050829A1 (ja) 2010-02-25
EP2088144B1 (de) 2011-12-28

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