DE602005026310D1 - Verfahren zur herstellung von ibandronat - Google Patents
Verfahren zur herstellung von ibandronatInfo
- Publication number
- DE602005026310D1 DE602005026310D1 DE602005026310T DE602005026310T DE602005026310D1 DE 602005026310 D1 DE602005026310 D1 DE 602005026310D1 DE 602005026310 T DE602005026310 T DE 602005026310T DE 602005026310 T DE602005026310 T DE 602005026310T DE 602005026310 D1 DE602005026310 D1 DE 602005026310D1
- Authority
- DE
- Germany
- Prior art keywords
- ibandronate
- production
- hydroxypropane
- monohydrate
- pentyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 title 1
- 229940015872 ibandronate Drugs 0.000 title 1
- DRPKUPBGKFMTRM-UHFFFAOYSA-N (2-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid Chemical compound CC(N)C(O)(P(O)(O)=O)P(O)(O)=O DRPKUPBGKFMTRM-UHFFFAOYSA-N 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 238000007040 multi-step synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04105407 | 2004-10-29 | ||
| PCT/EP2005/011404 WO2006045578A2 (en) | 2004-10-29 | 2005-10-25 | Process for the preparation of ibandronate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005026310D1 true DE602005026310D1 (de) | 2011-03-24 |
Family
ID=36097233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005026310T Active DE602005026310D1 (de) | 2004-10-29 | 2005-10-25 | Verfahren zur herstellung von ibandronat |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7214818B2 (de) |
| EP (1) | EP1807090B9 (de) |
| JP (1) | JP4560548B2 (de) |
| KR (1) | KR100880061B1 (de) |
| CN (1) | CN101048165B (de) |
| AT (1) | ATE497769T1 (de) |
| CA (1) | CA2585027C (de) |
| DE (1) | DE602005026310D1 (de) |
| ES (1) | ES2359415T3 (de) |
| IL (1) | IL182690A (de) |
| MX (1) | MX2007005114A (de) |
| TW (1) | TWI293304B (de) |
| WO (1) | WO2006045578A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007000087A (es) * | 2004-06-23 | 2007-11-06 | Teva Pharma | Acido ibandronico solido y cristalino. |
| WO2007074475A2 (en) * | 2005-12-27 | 2007-07-05 | Natco Pharma Limited | Novel polymorphic forms of ibandronate |
| ATE473990T1 (de) | 2006-06-23 | 2010-07-15 | Cipla Ltd | Verfahren zur synthese von ibandronat-natrium |
| CA2656053A1 (en) * | 2006-07-03 | 2008-01-10 | Generics [Uk] Limited | Novel process for the preparation of bisphosphonic acids |
| WO2008014510A2 (en) * | 2006-07-28 | 2008-01-31 | Dr. Reddy's Laboratories Limited | Crystalline form a of ibandronic acid and process for the preparation |
| TW200829256A (en) * | 2006-11-16 | 2008-07-16 | Teva Pharma | Crystalline forms of ibandronate sodium |
| CA2570949A1 (en) * | 2006-12-12 | 2008-06-12 | Apotex Pharmachem Inc. | Ibandronate sodium propylene glycol solvate and processes for the preparation thereof |
| CN101679465B (zh) * | 2007-04-11 | 2013-08-21 | 霍夫曼-拉罗奇有限公司 | 伊班膦酸盐的制备方法 |
| EP2316840A1 (de) * | 2007-04-19 | 2011-05-04 | Dr. Reddy's Laboratories Limited | Polymorphe von Sodium Ibandronat |
| US20090042839A1 (en) * | 2007-08-09 | 2009-02-12 | Sharon Avhar-Maydan | Crystalline forms of ibandronate sodium |
| US20090075944A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched ibandronate |
| WO2009093258A2 (en) * | 2008-01-24 | 2009-07-30 | Fleming Laboratories Limited | A new and improved process for the preparation of ibandronate sodium monohydrate |
| EP2180003A1 (de) | 2008-10-21 | 2010-04-28 | Zentiva, k.s. | Herstellung von Trinatriumbandronat |
| EP2192126B1 (de) | 2008-11-26 | 2013-03-27 | Synthon B.V. | Verfahren zur Herstellung von Zoledronsäure |
| US20100130746A1 (en) * | 2008-11-26 | 2010-05-27 | Martin Kas | Process for Making Zoledronic Acid |
| CN101863919B (zh) * | 2010-07-05 | 2011-11-23 | 武汉同源药业有限公司 | 一种化合物伊班膦酸钠的制备方法 |
| CN102093416B (zh) * | 2011-03-17 | 2013-07-24 | 南京恒生制药有限公司 | 一种合成伊班膦酸钠的方法 |
| CN103012155A (zh) * | 2012-11-29 | 2013-04-03 | 张家港市大伟助剂有限公司 | 一种n-甲基戊胺的制备方法 |
| CN103396332A (zh) * | 2013-08-19 | 2013-11-20 | 四川协力制药有限公司 | 3—[（n—甲基—n—戊基）氨基]丙酸盐酸盐的制备方法 |
| CN104628768A (zh) * | 2015-03-06 | 2015-05-20 | 江苏正大清江制药有限公司 | 一种伊班膦酸钠的制备方法 |
| CN114524925B (zh) * | 2020-11-23 | 2023-11-14 | 华润化学材料科技股份有限公司 | 钛系催化剂及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919321A (en) * | 1966-11-08 | 1975-11-11 | Hoffmann La Roche | Halo-substituted-5H-dibenzo{8 a,d{9 cyclohepten-5-ones |
| US4220611A (en) | 1978-06-29 | 1980-09-02 | Sandoz, Inc. | Polyoxyalkylene bridged phosphate esters |
| DE3623397A1 (de) | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3808074A1 (de) | 1988-03-11 | 1989-09-21 | Henkel Kgaa | Verfahren zur herstellung von azacycloalkan-2,2-diphosphonsaeuren |
| DE3822650A1 (de) | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4922007A (en) | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| PE20011065A1 (es) | 2000-02-01 | 2001-11-21 | Procter & Gamble | Proceso para fabricar bisfosfonatos geminales |
| KR100681282B1 (ko) | 2002-05-17 | 2007-02-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법 |
-
2005
- 2005-10-18 US US11/252,668 patent/US7214818B2/en active Active
- 2005-10-25 ES ES05799731T patent/ES2359415T3/es active Active
- 2005-10-25 CN CN2005800371320A patent/CN101048165B/zh not_active Expired - Fee Related
- 2005-10-25 AT AT05799731T patent/ATE497769T1/de active
- 2005-10-25 DE DE602005026310T patent/DE602005026310D1/de active Active
- 2005-10-25 KR KR1020077011938A patent/KR100880061B1/ko not_active IP Right Cessation
- 2005-10-25 WO PCT/EP2005/011404 patent/WO2006045578A2/en active Application Filing
- 2005-10-25 EP EP05799731A patent/EP1807090B9/de not_active Not-in-force
- 2005-10-25 CA CA2585027A patent/CA2585027C/en not_active Expired - Fee Related
- 2005-10-25 JP JP2007538322A patent/JP4560548B2/ja active Active
- 2005-10-25 MX MX2007005114A patent/MX2007005114A/es active IP Right Grant
- 2005-10-27 TW TW094137688A patent/TWI293304B/zh not_active IP Right Cessation
-
2007
- 2007-04-19 IL IL182690A patent/IL182690A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007005114A (es) | 2007-06-26 |
| US7214818B2 (en) | 2007-05-08 |
| TW200621792A (en) | 2006-07-01 |
| EP1807090B1 (de) | 2011-02-09 |
| EP1807090B9 (de) | 2011-11-09 |
| US20060094898A1 (en) | 2006-05-04 |
| IL182690A (en) | 2011-07-31 |
| CN101048165A (zh) | 2007-10-03 |
| ATE497769T1 (de) | 2011-02-15 |
| IL182690A0 (en) | 2007-09-20 |
| KR20070070246A (ko) | 2007-07-03 |
| EP1807090A2 (de) | 2007-07-18 |
| KR100880061B1 (ko) | 2009-01-22 |
| CN101048165B (zh) | 2010-12-01 |
| WO2006045578A2 (en) | 2006-05-04 |
| JP2008517964A (ja) | 2008-05-29 |
| JP4560548B2 (ja) | 2010-10-13 |
| CA2585027A1 (en) | 2006-05-04 |
| ES2359415T3 (es) | 2011-05-23 |
| TWI293304B (en) | 2008-02-11 |
| WO2006045578A3 (en) | 2006-08-17 |
| CA2585027C (en) | 2010-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602005026310D1 (de) | Verfahren zur herstellung von ibandronat | |
| CY1121703T1 (el) | Ιατρικη χρηση του πολυμορφου a toy ibanδρονικου | |
| TW200640940A (en) | Ibandronate polymorph B | |
| TW200801027A (en) | Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids | |
| ATE537136T1 (de) | Neues verfahren zur herstellung von säurechloriden | |
| ATE451380T1 (de) | Verfahren zur herstellung von bisphosphonsäureverbindungen | |
| ATE552230T1 (de) | Verfahren zur herstellung von derivaten aus 1-(2- halobiphenyl-4-yl)-cyclopropancarboxylsäure | |
| ATE489352T1 (de) | Verfahren zur herstellung von brenztraubensäure | |
| EA201170057A1 (ru) | Способ получения замещенных 2-аминотиазолонов | |
| ATE549315T1 (de) | Verfahren zur herstellung von kristallinem perindopril | |
| MX2009010850A (es) | Sintesis de ibandronato en multiples etapas. | |
| DE602005013007D1 (de) | Verfahren zur herstellung von lactonen | |
| ATE381532T1 (de) | Verfahren zur herstellung von gabapentin | |
| ATE502045T1 (de) | Verfahren zur herstellung von perindoprilerbumin | |
| DE602005025140D1 (de) | Verfahren zur herstellung von alkylphosphinaten | |
| DE602004014822D1 (de) | Neues verfahren zur herstellung von nitrooxyderivaten von paracetamol | |
| ATE519765T1 (de) | Verfahren zur herstellung von 3-hydroxymorphinan- derivaten | |
| ATE517890T1 (de) | Verfahren zur herstellung von reinem irbesartan | |
| DE602004030091D1 (de) | Verfahren zur reduktiven deshalogenierung | |
| ATE546458T1 (de) | Verfahren zur herstellung von 6-alpha, 9-alpha- | |
| BR112012012908A2 (pt) | processo de preparo de um derivado de combretastatina | |
| DE502005003019D1 (de) | Verfahren zur herstellung der enantiomeren formen von 2,3-diaminopropionsäurederivaten | |
| WO2012070896A3 (en) | Synthetic method of enantiomerically pure 2,2'-dihydroxy-1,1'-binaphthyl-3-carboxylic acid | |
| SE0402462D0 (sv) | New process | |
| DE602007007773D1 (de) | Verfahren zur synthese von ibandronat-natrium |