ATE473990T1 - Verfahren zur synthese von ibandronat-natrium - Google Patents
Verfahren zur synthese von ibandronat-natriumInfo
- Publication number
- ATE473990T1 ATE473990T1 AT07849673T AT07849673T ATE473990T1 AT E473990 T1 ATE473990 T1 AT E473990T1 AT 07849673 T AT07849673 T AT 07849673T AT 07849673 T AT07849673 T AT 07849673T AT E473990 T1 ATE473990 T1 AT E473990T1
- Authority
- AT
- Austria
- Prior art keywords
- synthesis
- ibandronate sodium
- present
- ibandronate
- sodium
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 title abstract 2
- 229960005236 ibandronic acid Drugs 0.000 title abstract 2
- MMMLYCSMYFFSPJ-UHFFFAOYSA-N 3-(hexan-2-ylamino)propanoic acid Chemical compound CCCCC(C)NCCC(O)=O MMMLYCSMYFFSPJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/04—Sodium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN994MU2006 | 2006-06-23 | ||
| PCT/IN2007/000255 WO2008035367A2 (en) | 2006-06-23 | 2007-06-22 | Process for the synthesis of ibandronate sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE473990T1 true ATE473990T1 (de) | 2010-07-15 |
Family
ID=39144580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07849673T ATE473990T1 (de) | 2006-06-23 | 2007-06-22 | Verfahren zur synthese von ibandronat-natrium |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8178712B2 (de) |
| EP (1) | EP2038291B1 (de) |
| JP (1) | JP5571378B2 (de) |
| KR (1) | KR101425429B1 (de) |
| AT (1) | ATE473990T1 (de) |
| AU (1) | AU2007298508B2 (de) |
| CA (1) | CA2652420C (de) |
| DE (1) | DE602007007773D1 (de) |
| NZ (1) | NZ573137A (de) |
| WO (1) | WO2008035367A2 (de) |
| ZA (1) | ZA200810024B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008004000A1 (en) * | 2006-07-03 | 2008-01-10 | Generics [Uk] Limited | Novel process for the preparation of bisphosphonic acids |
| CN102093416B (zh) * | 2011-03-17 | 2013-07-24 | 南京恒生制药有限公司 | 一种合成伊班膦酸钠的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2534391C2 (de) * | 1975-08-01 | 1983-01-13 | Henkel KGaA, 4000 Düsseldorf | 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren |
| JPS5414931A (en) * | 1977-07-05 | 1979-02-03 | Seitetsu Kagaku Co Ltd | Preparation of n-benzylglycine |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| JPS63190868A (ja) * | 1986-08-21 | 1988-08-08 | Kanegafuchi Chem Ind Co Ltd | 光学活性スルホニルオキシ化合物及びその化合物を用いる光学活性アミンの製造方法 |
| JPH11322687A (ja) * | 1998-05-12 | 1999-11-24 | Koei Chem Co Ltd | ホルムアミド類の製造方法 |
| JPH11349494A (ja) * | 1998-06-03 | 1999-12-21 | Toray Ind Inc | 光学分割用分離剤および光学異性体の吸着分離方法 |
| JP2001294558A (ja) * | 2000-04-12 | 2001-10-23 | Honshu Chem Ind Co Ltd | ノルボルネンー２−カルボン酸エステル類及びその製造方法 |
| CA2536229C (en) | 2003-08-21 | 2012-09-25 | Sun Pharmaceutical Industries Limited | A process for preparation of bisphosphonic acid compounds |
| JP4191008B2 (ja) * | 2003-11-04 | 2008-12-03 | 花王株式会社 | アミノカルボン酸エステルの製造法 |
| DE602004032577D1 (de) | 2003-12-23 | 2011-06-16 | Alchymars S P A | Amorphe Form das Natriumsalzes der Ibandronsäure |
| WO2006002348A2 (en) * | 2004-06-23 | 2006-01-05 | Teva Pharmaceutical Industies Ltd. | Solid and crystalline ibandronic acid |
| US7214818B2 (en) * | 2004-10-29 | 2007-05-08 | Hoffmann-La Roche Inc. | Method for synthesizing bisphosphonate |
-
2007
- 2007-06-22 JP JP2009516069A patent/JP5571378B2/ja not_active Expired - Fee Related
- 2007-06-22 KR KR1020087030889A patent/KR101425429B1/ko not_active IP Right Cessation
- 2007-06-22 WO PCT/IN2007/000255 patent/WO2008035367A2/en active Application Filing
- 2007-06-22 NZ NZ573137A patent/NZ573137A/en not_active IP Right Cessation
- 2007-06-22 DE DE602007007773T patent/DE602007007773D1/de active Active
- 2007-06-22 EP EP07849673A patent/EP2038291B1/de not_active Not-in-force
- 2007-06-22 AU AU2007298508A patent/AU2007298508B2/en not_active Ceased
- 2007-06-22 AT AT07849673T patent/ATE473990T1/de not_active IP Right Cessation
- 2007-06-22 US US12/303,918 patent/US8178712B2/en not_active Expired - Fee Related
- 2007-06-22 CA CA2652420A patent/CA2652420C/en not_active Expired - Fee Related
-
2008
- 2008-11-25 ZA ZA200810024A patent/ZA200810024B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2038291A2 (de) | 2009-03-25 |
| EP2038291B1 (de) | 2010-07-14 |
| KR20090023394A (ko) | 2009-03-04 |
| US20100228052A1 (en) | 2010-09-09 |
| WO2008035367A3 (en) | 2008-05-22 |
| WO2008035367A2 (en) | 2008-03-27 |
| WO2008035367B1 (en) | 2008-08-07 |
| JP2009541305A (ja) | 2009-11-26 |
| KR101425429B1 (ko) | 2014-08-01 |
| CA2652420A1 (en) | 2008-03-27 |
| CA2652420C (en) | 2014-01-14 |
| DE602007007773D1 (de) | 2010-08-26 |
| AU2007298508A1 (en) | 2008-03-27 |
| US8178712B2 (en) | 2012-05-15 |
| JP5571378B2 (ja) | 2014-08-13 |
| NZ573137A (en) | 2011-03-31 |
| AU2007298508B2 (en) | 2012-02-09 |
| ZA200810024B (en) | 2009-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |