DE3853457T2 - Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests. - Google Patents

Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests.

Info

Publication number
DE3853457T2
DE3853457T2 DE3853457T DE3853457T DE3853457T2 DE 3853457 T2 DE3853457 T2 DE 3853457T2 DE 3853457 T DE3853457 T DE 3853457T DE 3853457 T DE3853457 T DE 3853457T DE 3853457 T2 DE3853457 T2 DE 3853457T2
Authority
DE
Germany
Prior art keywords
fast
accuracy
simple performance
prothrombin test
prothrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3853457T
Other languages
English (en)
Other versions
DE3853457D1 (de
Inventor
Bruce Oberhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiovascular Diagnostics Inc
Original Assignee
Cardiovascular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiovascular Diagnostics Inc filed Critical Cardiovascular Diagnostics Inc
Application granted granted Critical
Publication of DE3853457D1 publication Critical patent/DE3853457D1/de
Publication of DE3853457T2 publication Critical patent/DE3853457T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
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    • B01F23/56—Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
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    • B01F31/31—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
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    • B01F35/7172—Feed mechanisms characterised by the means for feeding the components to the mixer using capillary forces
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DE3853457T 1987-04-03 1988-04-01 Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests. Expired - Fee Related DE3853457T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/033,817 US4849340A (en) 1987-04-03 1987-04-03 Reaction system element and method for performing prothrombin time assay
PCT/US1988/000980 WO1988007666A1 (en) 1987-04-03 1988-04-01 Element and method for performing biological assays accurately, rapidly and simply

Publications (2)

Publication Number Publication Date
DE3853457D1 DE3853457D1 (de) 1995-05-04
DE3853457T2 true DE3853457T2 (de) 1995-10-26

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10140699A1 (de) * 2001-08-24 2003-03-13 Roche Diagnostics Gmbh Anordnung und Verfahren zur Untersuchung der Fließfähigkeit einer physiologischen Flüssigprobe
DE10148210B4 (de) * 2001-09-28 2005-09-15 Ibidi Gmbh Flusskammer
US7517499B2 (en) 2001-09-28 2009-04-14 Ibidi Gmbh Flow chamber
DE10101576B4 (de) * 2001-01-15 2016-02-18 Presens Precision Sensing Gmbh Optischer Sensor und Sensorfeld

Families Citing this family (365)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164598A (en) * 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5204525A (en) * 1985-08-05 1993-04-20 Biotrack Capillary flow device
US5140161A (en) * 1985-08-05 1992-08-18 Biotrack Capillary flow device
US5144139A (en) * 1985-08-05 1992-09-01 Biotrack, Inc. Capillary flow device
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4918025A (en) * 1987-03-03 1990-04-17 Pb Diagnostic Systems, Inc. Self contained immunoassay element
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
US5209904A (en) * 1987-12-23 1993-05-11 Abbott Laboratories Agglutination reaction device utilizing selectively impregnated porous material
US5779976A (en) * 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5114350A (en) * 1989-03-08 1992-05-19 Cholestech Corporation Controlled-volume assay apparatus
US4957582A (en) * 1989-03-16 1990-09-18 Eastman Kodak Company Capillary transport zone coated with adhesive
IE940110L (en) * 1989-03-23 1990-09-23 Bunce Roger A Liquid transfer devices
US5039617A (en) * 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
EP0397424A3 (de) * 1989-05-08 1991-08-21 Biotrack, Inc. Mehrfachanalysesystem
US5147609A (en) * 1989-05-19 1992-09-15 Pb Diagnostic Systems, Inc. Assay element
IT1230744B (it) * 1989-07-07 1991-10-29 Instrumentation Lab Spa Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano.
JPH0810193B2 (ja) * 1989-08-21 1996-01-31 富士写真フイルム株式会社 生化学分析方法における点着異常判定方法
US5620657A (en) * 1989-11-27 1997-04-15 Behringwerke Ag Device and method for completing a fluidic circuit
US5104812A (en) * 1989-11-27 1992-04-14 Syntex (U.S.A.) Inc. Device and method for interrupting capillary flow
US5646046A (en) * 1989-12-01 1997-07-08 Akzo Nobel N.V. Method and instrument for automatically performing analysis relating to thrombosis and hemostasis
US5068181A (en) * 1989-12-01 1991-11-26 Akzo N.V. Method of monitoring reagent delivery in a scanning spectrophotometer
US5110724A (en) * 1990-04-02 1992-05-05 Cholestech Corporation Multi-analyte assay device
US4986964A (en) * 1990-04-19 1991-01-22 Center For Innovative Technology Clot retractometer
WO1991018276A1 (en) * 1990-05-22 1991-11-28 Kelly Kenneth A Microassay strip device for immunoassay
TW221493B (de) * 1990-07-10 1994-03-01 Cardiovascular Diagnostics Inc
WO1992005440A1 (en) * 1990-09-26 1992-04-02 Akers Research Corporation Improved ligand assay
ZA92804B (en) 1991-02-06 1992-12-30 Igen Inc Methods and apparatus for improved luminescence assays
EP0501796A3 (en) * 1991-03-01 1993-10-06 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5207984A (en) * 1991-03-11 1993-05-04 Miles Inc. Blood sample collection and test device
US5877028A (en) 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
US5998220A (en) 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
BE1005090A5 (fr) * 1991-06-25 1993-04-13 Saliva Diagnostic Systems Inc Dispositif d'echantillonnage et systeme d'adequation d'echantillon.
US5540888A (en) * 1991-11-11 1996-07-30 British Technology Group Limited Liquid transfer assay devices
JP3382632B2 (ja) * 1992-03-13 2003-03-04 オリンパス光学工業株式会社 生体関連物質の測定方法およびそれに用いる反応容器
US5443959A (en) * 1992-09-09 1995-08-22 Tokuyama Corporation Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof
US5344754A (en) * 1993-01-13 1994-09-06 Avocet Medical, Inc. Assay timed by electrical resistance change and test strip
WO1994019690A1 (en) * 1993-02-17 1994-09-01 Cardiovascular Diagnostics, Inc. Dry chemistry cascade immunoassay and affinity assay
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5670329A (en) * 1993-05-28 1997-09-23 Cardiovascular Diagnostics, Inc. Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field
US6521187B1 (en) 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates
US6203759B1 (en) 1996-05-31 2001-03-20 Packard Instrument Company Microvolume liquid handling system
US6537817B1 (en) 1993-05-31 2003-03-25 Packard Instrument Company Piezoelectric-drop-on-demand technology
DE4323672A1 (de) * 1993-07-15 1995-01-19 Boehringer Mannheim Gmbh Vorrichtung zur gleichzeitigen Bestimmung von Analyten
CA2168967C (en) * 1993-08-31 2005-03-29 George R. Lennert Power supply monitor and control for medical instrument
CA2168966C (en) * 1993-08-31 2007-07-31 George R. Lennert Analog heater control for medical instrument
ES2220914T3 (es) * 1993-08-31 2004-12-16 Roche Diagnostics Corporation Reactivo y metodo para su suso.
US5522255A (en) 1993-08-31 1996-06-04 Boehringer Mannheim Corporation Fluid dose, flow and coagulation sensor for medical instrument
US5526111A (en) * 1993-08-31 1996-06-11 Boehringer Mannheim Corporation Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control
US5841023A (en) * 1993-08-31 1998-11-24 Boehringer Mannheim Corporation Magnet for medical instrument
US5478751A (en) * 1993-12-29 1995-12-26 Abbott Laboratories Self-venting immunodiagnositic devices and methods of performing assays
US5582907A (en) * 1994-07-28 1996-12-10 Pall Corporation Melt-blown fibrous web
US6074869A (en) * 1994-07-28 2000-06-13 Pall Corporation Fibrous web for processing a fluid
GB9416002D0 (en) * 1994-08-08 1994-09-28 Univ Cranfield Fluid transport device
US5504011A (en) * 1994-10-21 1996-04-02 International Technidyne Corporation Portable test apparatus and associated method of performing a blood coagulation test
JP3388060B2 (ja) * 1994-11-25 2003-03-17 日本碍子株式会社 流体の特性測定用素子及び流体の特性測定装置
AU689143B2 (en) * 1994-12-02 1998-03-26 Cardiovascular Diagnostics, Inc. Improved method and analytical system for performing fibrinogen assays accurately, rapidly and simply
US5508521A (en) * 1994-12-05 1996-04-16 Cardiovascular Diagnostics Inc. Method and apparatus for detecting liquid presence on a reflecting surface using modulated light
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
DE19512710A1 (de) * 1995-04-10 1996-10-17 Behringwerke Ag Biosensor
DE19523061A1 (de) * 1995-06-24 1997-01-02 Boehringer Mannheim Gmbh Element und System zum Sammeln, Transportieren und Lagern von zu analysierendem Probenmaterial
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US20020090644A1 (en) * 1999-05-21 2002-07-11 Weigl Bernhard H. Microscale diffusion immunoassay
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
CA2256572C (en) * 1996-06-14 2008-08-05 Minnesota Mining And Manufacturing Company Display unit and methods of displaying an image
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
WO1998000231A1 (en) * 1996-06-28 1998-01-08 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
US5945345A (en) * 1996-08-27 1999-08-31 Metrika, Inc. Device for preventing assay interference using silver or lead to remove the interferant
US5832165A (en) 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays
EP0961919A1 (de) * 1996-09-24 1999-12-08 Case Western Reserve University Vorrichtung für optische und elektrochemische messungen von proben im mikroliterbereich
US7153651B1 (en) * 1996-10-31 2006-12-26 Inverness Medical - Biostar, Inc. Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof
US6703247B1 (en) 1996-12-23 2004-03-09 American Registry Of Pathology Apparatus and methods for efficient processing of biological samples on slides
US6565815B1 (en) 1997-02-28 2003-05-20 Cepheid Heat exchanging, optically interrogated chemical reaction assembly
US8293064B2 (en) * 1998-03-02 2012-10-23 Cepheid Method for fabricating a reaction vessel
US6150174A (en) * 1997-03-05 2000-11-21 Diametrics Medical, Inc. Method for measurement of whole blood coagulation parameters
US6052224A (en) * 1997-03-21 2000-04-18 Northern Edge Associates Microscope slide system and method of use
US5910288A (en) * 1997-07-10 1999-06-08 Hewlett-Packard Company Method and apparatus for mixing a thin film of fluid
US6066243A (en) * 1997-07-22 2000-05-23 Diametrics Medical, Inc. Portable immediate response medical analyzer having multiple testing modules
US6061128A (en) * 1997-09-04 2000-05-09 Avocet Medical, Inc. Verification device for optical clinical assay systems
US6222619B1 (en) * 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
EP1018012A4 (de) * 1997-09-26 2002-10-09 Univ Washington Simultan ablaufende partikeltrennung und chemische reaktion
DE19753849A1 (de) * 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit sich verjüngendem Kapillarkanal
US5908786A (en) * 1997-12-12 1999-06-01 Akzo Nobel, N.V. Blood coagulation monitoring device with liquid crystal and gradient heater
SE520341C2 (sv) * 1998-01-14 2003-06-24 Hemocue Ab Metod och förfarande för blandning i ett tunt vätskeskick
SE9800070D0 (sv) 1998-01-14 1998-01-14 Hemocue Ab Blandningsmetod
US5975153A (en) * 1998-02-13 1999-11-02 Roche Diagnostics Corporation Capillary fill test device with improved fluid delivery
SE9800590D0 (sv) * 1998-02-26 1998-02-26 Global Hemostasis Inst Mgr Ab Determination of polymerization/coagulation in a fluid
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6312888B1 (en) 1998-06-10 2001-11-06 Abbott Laboratories Diagnostic assay for a sample of biological fluid
US6165795A (en) * 1998-06-25 2000-12-26 Cardiovascular Diagnostics, Inc. Methods for performing fibrinogen assays using dry chemical reagents containing ecarin and magnetic particles
US6084660A (en) * 1998-07-20 2000-07-04 Lifescan, Inc. Initiation of an analytical measurement in blood
US6521182B1 (en) * 1998-07-20 2003-02-18 Lifescan, Inc. Fluidic device for medical diagnostics
US6830934B1 (en) * 1999-06-15 2004-12-14 Lifescan, Inc. Microdroplet dispensing for a medical diagnostic device
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6186659B1 (en) * 1998-08-21 2001-02-13 Agilent Technologies Inc. Apparatus and method for mixing a film of fluid
US6482306B1 (en) 1998-09-22 2002-11-19 University Of Washington Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer
US6498497B1 (en) * 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
US20060216744A1 (en) * 1998-12-23 2006-09-28 American Registry Of Pathology Armed Forces Institute Of Pathology Apparatus and methods for efficient processing of biological samples on slides
CN1195585C (zh) * 1998-12-23 2005-04-06 病理学美国登记处 采用试剂处理生物样品的方法
FR2792333B1 (fr) * 1999-04-14 2003-01-24 Labonord Dispositif de depot de cellules sur une plaque d'analyse
US20020019062A1 (en) * 1999-06-18 2002-02-14 Peter Lea Assay devices
US6258593B1 (en) * 1999-06-30 2001-07-10 Agilent Technologies Inc. Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
US6645359B1 (en) * 2000-10-06 2003-11-11 Roche Diagnostics Corporation Biosensor
US6743399B1 (en) 1999-10-08 2004-06-01 Micronics, Inc. Pumpless microfluidics
US6136549A (en) * 1999-10-15 2000-10-24 Feistel; Christopher C. systems and methods for performing magnetic chromatography assays
US6319719B1 (en) 1999-10-28 2001-11-20 Roche Diagnostics Corporation Capillary hematocrit separation structure and method
US6629057B2 (en) 1999-11-05 2003-09-30 Beckman Coulter, Inc. Comprehensive verification systems and methods for analyzer-read clinical assays
US6338969B1 (en) * 1999-11-15 2002-01-15 Bayer Corporation Assay test system for regulating temperature
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
JP2001159618A (ja) * 1999-12-03 2001-06-12 Matsushita Electric Ind Co Ltd バイオセンサ
CZ20022206A3 (cs) 1999-12-24 2002-10-16 Roche Diagnostics Gmbh Systém analýzy pomocí testovacího prvku
FR2803225B1 (fr) * 1999-12-29 2002-06-14 Biomerieux Sa Appareil d'analyse a compartiment reactionnel a geometrie variable, procede de mixage et de guidage de liquides
US6562210B1 (en) * 1999-12-30 2003-05-13 Roche Diagnostics Corporation Cell for electrochemical anaylsis of a sample
DE10002500A1 (de) * 2000-01-21 2001-07-26 Univ Albert Ludwigs Freiburg Kapillarkraftmischer
US6406672B1 (en) 2000-01-28 2002-06-18 Roche Diagnostics Plasma retention structure providing internal flow
US6451264B1 (en) * 2000-01-28 2002-09-17 Roche Diagnostics Corporation Fluid flow control in curved capillary channels
DE10005203A1 (de) * 2000-02-05 2001-08-16 Bayerische Motoren Werke Ag Vermessungsvorrichtung zum Abbilden und Aufzeichnen eines dreidimensionalen Objekts
US6323040B1 (en) * 2000-02-15 2001-11-27 Ryan S. Raz System for biological specimen preparation
US6402704B1 (en) * 2000-04-18 2002-06-11 Sonexxus Incorporated Prothrombin test apparatus for home use
KR20030014219A (ko) * 2000-05-09 2003-02-15 파마네틱스 인코포레이티드 혈소판 기능 측정법 및 이에 사용하는 시약
US6557427B2 (en) * 2000-05-24 2003-05-06 Micronics, Inc. Capillaries for fluid movement within microfluidic channels
IL154081A0 (en) * 2000-07-31 2003-07-31 Lifescan Inc Method and apparatus for detecting the presence of a fluid on a test strip
AU2000280282A1 (en) * 2000-10-17 2002-04-29 Abbott Laboratories Diagnostic assay for a sample of biological fluid
GB0028647D0 (en) * 2000-11-24 2001-01-10 Nextgen Sciences Ltd Apparatus for chemical assays
US7144495B2 (en) * 2000-12-13 2006-12-05 Lifescan, Inc. Electrochemical test strip with an integrated micro-needle and associated methods
US6620310B1 (en) * 2000-12-13 2003-09-16 Lifescan, Inc. Electrochemical coagulation assay and device
ATE281232T1 (de) * 2000-12-28 2004-11-15 Hoffmann La Roche Verfahren zur behandlung von nukleinsaüreproben mittels schwingung eines teiles einer kartuschenwandung, system und kartusche zur durchführung desselben
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
EP1372848A4 (de) * 2001-03-09 2006-08-09 Biomicro Systems Inc Verfahren und system zur mikrofluiden zusammenwirkung mit arrays
WO2002084291A1 (fr) * 2001-04-12 2002-10-24 Arkray, Inc. Instrument d'analyse de prelevement
US6759009B2 (en) * 2001-05-04 2004-07-06 Portascience Incorporated Method and device for clotting time assay
US20030211551A1 (en) * 2001-05-09 2003-11-13 Mahan Donald E Platelet function assay and reagent therefor
JP4222838B2 (ja) * 2001-05-17 2009-02-12 バイエル・ヘルスケア・エルエルシー 温度を調整するための検定試験系
US7473398B2 (en) 2001-05-25 2009-01-06 Roche Diagnostics Operations, Inc. Biosensor
EP1404218A4 (de) * 2001-06-12 2008-11-19 Pelikan Technologies Inc Thermischer sensor für die fluiddetektion
US7402282B2 (en) 2001-07-20 2008-07-22 Ortho-Clinical Diagnostics, Inc. Auxiliary sample supply for a clinical analyzer
US7824616B2 (en) * 2001-07-27 2010-11-02 Arkray, Inc. Analyzing instrument
US6678542B2 (en) * 2001-08-16 2004-01-13 Optiscan Biomedical Corp. Calibrator configured for use with noninvasive analyte-concentration monitor and employing traditional measurements
US6902904B2 (en) 2001-08-27 2005-06-07 Pharmanetics Incorporated Coagulation assay reagents containing lanthanides
FR2829576B1 (fr) * 2001-09-12 2003-10-31 Bio Merieux Procede et dispositif d'isolement et/ou determination d'un analyte
DE10151778A1 (de) * 2001-10-19 2003-05-08 Philips Corp Intellectual Pty Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel
US7050157B2 (en) * 2001-11-08 2006-05-23 Optiscan Biomedical Corp. Reagent-less whole-blood glucose meter
US6989891B2 (en) 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
US6680177B2 (en) * 2001-12-07 2004-01-20 Cardiovascular Diagnostics, Inc. Low molecular weight heparin assay, system and reagent therefor
JP2005513503A (ja) * 2001-12-21 2005-05-12 ビアコーレ・アー・ベー 結合物質の固定化
MXPA04006861A (es) 2002-01-18 2005-06-20 Univ Utah Res Found Deteccion de polimorfismos de nucleotidos individuales utilizando guias de onda planas.
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
JP3892743B2 (ja) * 2002-03-01 2007-03-14 日本碍子株式会社 反応セルおよびその使用方法
US20060134713A1 (en) 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
WO2003083489A1 (en) 2002-03-25 2003-10-09 Vector Ii, Inc. System for performing blood coagulation assays and measuring blood clotting times
US7524462B2 (en) * 2002-03-29 2009-04-28 Agilent Technologies, Inc. Capillary flow for a heterogenous assay in a micro-channel environment
ES2252358T3 (es) * 2002-04-09 2006-05-16 Cholestech Corporation Metodo y dispositivo de ensayo para la cuantificacion del colesterol asociado a lipoproteinas de alta densidad.
US7115421B2 (en) * 2002-04-17 2006-10-03 Biosafe Medical Technologies, Inc. Method and device for measurement of hematocrit
DE10219154A1 (de) * 2002-04-29 2003-11-20 Siemens Ag Verfahren zur Überwachung der Verfügbarkeit von Verbindungen in MPLS-Netzen
AU2003235970A1 (en) * 2002-04-30 2003-11-17 Arkray, Inc. Analysis instrument, sample analysis method and analysis device using the instrument, and method of forming opening in the instrument
US7468162B2 (en) * 2002-04-30 2008-12-23 Arkray, Inc. Analytical instrument
US7285425B2 (en) * 2002-05-14 2007-10-23 Siemens Medical Solutions Diagnostics Assay test system for regulating temperature
US6958132B2 (en) * 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
US7919308B2 (en) * 2002-06-14 2011-04-05 Agilent Technologies, Inc. Form in place gaskets for assays
US7553448B2 (en) * 2002-06-20 2009-06-30 Bioveris Corporation Electrochemiluminescence flow cell and flow cell components
AUPS309002A0 (en) 2002-06-20 2002-07-11 Vision Biosystems Limited A covertile for a substrate
US6939450B2 (en) * 2002-10-08 2005-09-06 Abbott Laboratories Device having a flow channel
JP3746756B2 (ja) * 2002-10-22 2006-02-15 株式会社日立製作所 溶液攪拌装置、溶液攪拌方法
US7126676B2 (en) * 2002-11-07 2006-10-24 Frank Anthony Greco Spectral analysis of light scattered from clotting blood
CA2492486A1 (en) * 2002-11-12 2004-05-27 Inverness Medical Switzerland Gmbh Photometric determination of coagulation time in undiluted whole blood
EP1419818B1 (de) * 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Vorrichtung zum schrittweisen Transport von Flüssigkeit unter Ausnutzung von Kapillarkräften
US20040101439A1 (en) * 2002-11-21 2004-05-27 Fusco Adam J Biological and chemical reaction devices and methods of manufacture
US7053783B2 (en) 2002-12-18 2006-05-30 Biovigilant Systems, Inc. Pathogen detector system and method
US6983177B2 (en) * 2003-01-06 2006-01-03 Optiscan Biomedical Corporation Layered spectroscopic sample element with microporous membrane
US20040132168A1 (en) * 2003-01-06 2004-07-08 Peter Rule Sample element for reagentless whole blood glucose meter
US20040131088A1 (en) * 2003-01-08 2004-07-08 Adtran, Inc. Shared T1/E1 signaling bit processor
ATE510605T1 (de) 2003-03-14 2011-06-15 Univ Columbia Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
WO2004085995A2 (en) * 2003-03-24 2004-10-07 Rosedale Medical Inc. Analyte concentration detection devices and methods
AU2004231988B2 (en) * 2003-04-16 2010-04-15 Drexel University Acoustic blood analyzer for assessing blood properties
GB0313015D0 (en) * 2003-06-06 2003-07-09 Hall Effect Technologies Ltd Method and device for analysing a liquid
EP1666136B1 (de) * 2003-07-24 2008-10-15 AOGAKI, Ryoichi Mikroreaktor mit magnetischer barriere
US7588733B2 (en) 2003-12-04 2009-09-15 Idexx Laboratories, Inc. Retaining clip for reagent test slides
KR100639776B1 (ko) * 2004-01-05 2006-10-27 바이오메드포토닉스 주식회사 측방 유동 정량 검정 방법 및 이를 위한 스트립과 레이저유발 표면형광 검출 장치 및 소형 스캐너
EP1711590B1 (de) 2004-01-08 2016-12-14 Dako Denmark A/S Vorrichtung und verfahren zur bearbeitung biologischer proben und reservoir dafür
TWI258586B (en) * 2004-01-13 2006-07-21 Neupro Technology Co Ltd Immunochemical detection device
US7439069B2 (en) * 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
US7422905B2 (en) * 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
ATE385572T1 (de) * 2004-03-05 2008-02-15 Egomedical Swiss Ag Analyttestsystem zur bestimmung der konzentration eines analyten in einer physiologischen flüssigkeit
US7399637B2 (en) * 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US7906000B2 (en) * 2004-04-23 2011-03-15 Arkray, Inc. Analyzer and method of manufacturing the same
WO2005111580A1 (en) * 2004-05-07 2005-11-24 Optiscan Biomedical Corporation Sample element with fringing-reduction capabilities
US8343074B2 (en) * 2004-06-30 2013-01-01 Lifescan Scotland Limited Fluid handling devices
US20060002817A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Flow modulation devices
US20060000709A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Methods for modulation of flow in a flow pathway
US20060001551A1 (en) * 2004-06-30 2006-01-05 Ulrich Kraft Analyte monitoring system with wireless alarm
US20060019406A1 (en) * 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
CN100595564C (zh) 2004-07-30 2010-03-24 百维吉伦特系统有限公司 病原体和粒子检测器系统和方法
EP1776464B1 (de) 2004-08-13 2009-10-07 Egomedical Technologies AG Analyttestsystem zur bestimmung der konzentration eines analyten in einer physiologischen oder wässrigen flüssigkeit
EP1637882B1 (de) * 2004-09-09 2007-08-08 Analyticon Biotechnologies AG Lateralflussmessvorrichtung und Messverfahren für Analyten
WO2006036592A1 (en) * 2004-09-23 2006-04-06 University Of Washington Microscale diffusion immunoassay utilizing multivalent reactants
US20060068500A1 (en) * 2004-09-28 2006-03-30 Kimberly-Clark Worldwide, Inc. Detecting yeast infections using a lateral flow assay
US20060078471A1 (en) * 2004-10-12 2006-04-13 Witty Thomas R Apparatus and method for a precision flow assay
DE502004006789D1 (de) * 2004-11-25 2008-05-21 Roche Diagnostics Gmbh Vorrichtung zum Analysieren von Proben
US20060134387A1 (en) * 2004-12-20 2006-06-22 William Gottermeier Multilayer article formed by adhesive ablation
AT502915B1 (de) * 2004-12-23 2008-01-15 Hoffmann La Roche Vorrichtung zur thermostatisierung einer messzelle in einem analysator und messzelle, welche in einen analysator austauschbar einsetzbar ist
US20070144976A1 (en) * 2004-12-24 2007-06-28 Matthias Franzreb Micro-reactor
US8936755B2 (en) 2005-03-02 2015-01-20 Optiscan Biomedical Corporation Bodily fluid composition analyzer with disposable cassette
US20060194325A1 (en) 2005-02-14 2006-08-31 Gable Jennifer H Fluid handling cassette with a fluid control interface
US20070103678A1 (en) * 2005-02-14 2007-05-10 Sterling Bernhard B Analyte detection system with interferent identification and correction
JP4586130B2 (ja) * 2005-02-22 2010-11-24 丸石化成株式会社 検体液採取器具
US7189522B2 (en) * 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
EP1866646A1 (de) * 2005-03-29 2007-12-19 Inverness Medical Switzerland GmbH Hybride vorrichtung
US7740804B2 (en) * 2005-04-12 2010-06-22 Chromedx Inc. Spectroscopic sample holder
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
US8211279B2 (en) 2005-06-03 2012-07-03 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
WO2006137334A1 (ja) * 2005-06-23 2006-12-28 Arkray, Inc. 分析用具
KR101283071B1 (ko) * 2005-07-15 2013-07-05 바이오비질런트 시스템즈 인코포레이티드 병원체 및 입자 검출기 시스템 및 방법
ATE499607T1 (de) * 2005-08-31 2011-03-15 Egomedical Technologies Ag Analytentestsystem unter verwendung nichtenzymatischer analytenerkennungselemente
JP2009506332A (ja) * 2005-08-31 2009-02-12 エゴメディカル テクノロジーズ アクチエンゲゼルシャフト 凝固検査系
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
CA2624059C (en) 2005-09-30 2019-04-02 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US9561001B2 (en) 2005-10-06 2017-02-07 Optiscan Biomedical Corporation Fluid handling cassette system for body fluid analyzer
US7344893B2 (en) * 2005-10-13 2008-03-18 Auric Enterprises, Llc Immuno-gold lateral flow assay
US8153444B2 (en) * 2005-10-13 2012-04-10 Auric Enterprises, Llc Immuno gold lateral flow assay
US8075852B2 (en) * 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
JP5175213B2 (ja) * 2005-12-22 2013-04-03 ハネウェル・インターナショナル・インコーポレーテッド 携帯用サンプル分析システム
JP5028804B2 (ja) * 2006-01-19 2012-09-19 ソニー株式会社 機能デバイス
GB2438669A (en) * 2006-03-07 2007-12-05 Inverness Medical Switzerland Sensing apparatus having a pair of coils and an oscillating member
EP2005168A4 (de) * 2006-03-09 2009-05-20 Biosite Inc Verfahren und zusammensetzung zur diagnose von krankheiten der aorta
US20080261261A1 (en) * 2006-03-31 2008-10-23 Kmg2 Sensors Corporation System/unit and method employing a plurality of magnetoelastic sensor elements for automatically quantifying parameters of whole blood and platelet-rich plasma
US7837941B2 (en) 2006-04-07 2010-11-23 Agamatrix, Inc. Method and apparatus for monitoring alteration of flow characteristics in a liquid sample
AU2007253702A1 (en) 2006-05-22 2007-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
GB0611701D0 (en) * 2006-06-14 2006-07-26 Biochrom Ltd Analytical apparatus
AU2007265628B2 (en) 2006-06-23 2012-12-06 Perkinelmer Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
EP2034318B1 (de) * 2006-06-26 2013-09-04 Nippon Telegraph and Telephone Corporation Durchflusszelle und verfahren zur herstellung davon
BRPI0714393A2 (pt) * 2006-07-17 2013-03-26 Universal Biosensors Pty Ltd detecÇço eletroquimica da mobilidade das partÍculas magnÉticas
US7749775B2 (en) * 2006-10-03 2010-07-06 Jonathan Scott Maher Immunoassay test device and method of use
US20080101987A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Analytical test strip with electroluminescent lamp
US7384798B2 (en) * 2006-10-31 2008-06-10 Hewlett-Packard Development Company, L.P. Method of detecting analytes in a microfluidic sample and a system for performing the same
US20080101986A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Analytical test strip with electroluminescent module
ES2388110T3 (es) * 2006-12-12 2012-10-09 Koninklijke Philips Electronics N.V. Dispositivo de sensor microelectrónico para detectar partículas de marcador
WO2008071218A1 (en) * 2006-12-14 2008-06-19 Egomedical Swiss Ag Monitoring device
EP2126587B1 (de) * 2007-01-09 2010-09-29 Cholestech Corporation Vorrichtung und verfahren zur messung des ldl-assoziierten cholesterols
WO2008092470A1 (en) * 2007-01-29 2008-08-07 Egomedical Swiss Ag Resealeable container for storing moisture sensitive test elements
US8361782B2 (en) * 2007-05-02 2013-01-29 Siemens Healthcare Diagnostics, Inc. Piezo dispensing of a diagnostic liquid into microfluidic devices
JP5461389B2 (ja) * 2007-05-02 2014-04-02 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド 試薬表面への診断液のピエゾ計量分配
US8597190B2 (en) 2007-05-18 2013-12-03 Optiscan Biomedical Corporation Monitoring systems and methods with fast initialization
WO2009029561A2 (en) * 2007-08-24 2009-03-05 Advanced Liquid Logic, Inc. Bead manipulations on a droplet actuator
JP5112441B2 (ja) * 2007-09-04 2013-01-09 パナソニック株式会社 血液分析素子とそれを用いた血液分析装置
WO2009057024A1 (en) 2007-10-29 2009-05-07 Koninklijke Philips Electronics N. V. Frustrated total internal reflection biosensor cartridge
KR100886914B1 (ko) * 2007-11-01 2009-03-09 주식회사 아이센스 혈액 분석 장치용 카트리지 및 이를 이용한 혈액 분석 장치
WO2009060358A2 (en) * 2007-11-05 2009-05-14 Koninklijke Philips Electronics N. V. Method for detecting redispersion of beads
JP2011504591A (ja) * 2007-11-26 2011-02-10 アトノミックス アクティーゼルスカブ 信号対ノイズ比を増すための手段および方法を備える、統合型分離および検出カートリッジ
US8628976B2 (en) * 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
JP2011514182A (ja) 2008-02-04 2011-05-06 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 流体分離装置、システム、及び方法
WO2009109997A1 (en) * 2008-03-07 2009-09-11 Advanced Microdevices Pvt Ltd Method and device for particle removal and droplet preparation for qualitative and quantitative bioanalysis
SE533103C2 (sv) * 2008-04-01 2010-06-29 Tommy Forsell Blodviskositetsanalys
EP2293719B1 (de) 2008-05-30 2015-09-09 Intuity Medical, Inc. Schnittstelle zwischen einer Vorrichtung zur entnahme von Körperflüssigkeitsproben und der Entnahmestelle
WO2009148624A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Detection meter and mode of operation
WO2009148626A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Medical diagnostic devices and methods
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
JP5461556B2 (ja) * 2008-08-21 2014-04-02 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド 尿残渣分析用多層スライド
MX2011003602A (es) 2008-11-07 2011-04-27 Hoffmann La Roche Sustancias de relleno granulado fino para peliculas de reaccion fotometrica.
WO2010070521A1 (en) 2008-12-18 2010-06-24 Koninklijke Philips Electronics N.V. Sensing device for sensing a fluid
US8042748B2 (en) 2008-12-19 2011-10-25 Zodiac Pool Systems, Inc. Surface disruptor for laminar jet fountain
US8177141B2 (en) * 2008-12-19 2012-05-15 Zodiac Pool Systems, Inc. Laminar deck jet
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US8586347B2 (en) 2010-09-15 2013-11-19 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
WO2010118539A2 (en) 2009-04-14 2010-10-21 Biocartis Sa Hifu induced cavitation with reduced power threshold
CA2752823C (en) 2009-04-15 2016-08-30 Biocartis Sa Protection of bioanalytical sample chambers
ES2822105T3 (es) 2009-04-15 2021-04-29 Biocartis Nv Sistema de detección óptica para monitorizar la reacción rtPCR
EP2421649B1 (de) * 2009-04-23 2018-01-24 Dublin City University Lateralstrom-assayvorrichtung zur überwachung von koagulation und verfahren dafür
JP5766180B2 (ja) 2009-05-06 2015-08-19 ビオカルティ ナームローゼ フェノーツハップＢｉｏｃａｒｔｉｓ ＮＶ 試料キャリヤを切断するための装置
EP2437887B1 (de) 2009-06-04 2016-05-11 Lockheed Martin Corporation Mikrofluidischer chip für dna analyse von mehrfachen proben
US9554742B2 (en) 2009-07-20 2017-01-31 Optiscan Biomedical Corporation Fluid analysis system
US8928877B2 (en) 2011-07-06 2015-01-06 Optiscan Biomedical Corporation Sample cell for fluid analysis system
AU2010276082B2 (en) * 2009-07-20 2015-06-18 Monash University Three-dimensional microfluidic systems
US8731638B2 (en) 2009-07-20 2014-05-20 Optiscan Biomedical Corporation Adjustable connector and dead space reduction
EP2492665A1 (de) * 2009-10-19 2012-08-29 Tokyo Institute of Technology Biosensor mit magnetischen mikropartikeln
IN2012DN03245A (de) 2009-11-13 2015-10-23 Ventana Med Syst Inc
US9498791B2 (en) 2009-11-13 2016-11-22 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
WO2011065981A1 (en) 2009-11-30 2011-06-03 Intuity Medical, Inc. Calibration material delivery devices and methods
EP2513637B1 (de) * 2009-12-18 2020-07-15 Koninklijke Philips N.V. Apparat zur bestimmung einer substanz
US9132423B2 (en) 2010-01-29 2015-09-15 Micronics, Inc. Sample-to-answer microfluidic cartridge
ES2739038T3 (es) 2010-04-08 2020-01-28 Hemosonics Llc Visualización de parámetros hemostáticos
EP2580589B1 (de) 2010-06-09 2016-08-31 Optiscan Biomedical Corporation Messung von analyten in einer flüssigkeitsprobe aus einem patienten
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
CN103079706A (zh) 2010-06-30 2013-05-01 Csem瑞士电子和微技术研究发展中心股份有限公司 移液管头、移液管系统和借助该移液管头和系统进行分析的方法
EP2591334A1 (de) * 2010-07-09 2013-05-15 Koninklijke Philips Electronics N.V. Kartusche mit massenherstellungskonzept
CN103118785B (zh) 2010-08-05 2015-11-25 雅培医护站股份有限公司 使用易感磁微珠捕获的免疫测定方法和装置
WO2012019108A1 (en) 2010-08-05 2012-02-09 Abbott Point Of Care Inc. Magnetic immunosensor with trench configuration and method of use
EP2601526B1 (de) 2010-08-05 2016-12-21 Abbott Point Of Care, Inc. Magnetischer immunsensor und anwendungsverfahren dafür
WO2012019109A1 (en) 2010-08-05 2012-02-09 Abbott Point Of Care Inc. Oscillating immunoassay method and device
GB201014316D0 (en) 2010-08-27 2010-10-13 Univ Dublin City A agglutination assay method and device
EP2624955A1 (de) * 2010-10-07 2013-08-14 BOEHRINGER INGELHEIM microParts GmbH Mikrofluidische plattform
CA2814720C (en) 2010-10-15 2016-12-13 Lockheed Martin Corporation Micro fluidic optic design
US9522396B2 (en) 2010-12-29 2016-12-20 S.D. Sight Diagnostics Ltd. Apparatus and method for automatic detection of pathogens
US8603835B2 (en) * 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
PT2676136T (pt) 2011-02-15 2021-03-25 Hemosonics Llc Dispositivos, sistemas e métodos para avaliação de hemostasia
JP6019485B2 (ja) * 2011-03-24 2016-11-02 ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツングＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ ｍｉｃｒｏＰａｒｔｓ ＧｍｂＨ 血液濾過器具及び方法
US20120294767A1 (en) 2011-05-19 2012-11-22 Hemosonics Llc Portable hemostasis analyzer
EP2726852B1 (de) * 2011-06-30 2020-11-25 Koninklijke Philips N.V. Mehrfache untersuchungen einer probe
EP3750480B1 (de) 2011-08-03 2022-02-02 Intuity Medical, Inc. Vorrichtung zur entnahme von körperflüssigkeiten
KR102090934B1 (ko) 2012-01-09 2020-03-19 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 마이크로유체 반응기 시스템
US9588113B2 (en) 2012-02-22 2017-03-07 Church & Dwight Co., Inc. Methods for electronic analyte assaying
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
EP2926115B1 (de) 2012-11-30 2021-05-26 The University of North Carolina At Chapel Hill Verfahren und systeme zur bestimmung der physikalischer eigenschaften einer probe in einer tragbaren point-of-care-diagnosevorrichtung
CN104919191B (zh) 2012-12-21 2019-07-09 精密公司 流体回路及相关的制造方法
EP3549674B1 (de) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Filme mit geringere elastizität zur mikrofluidischen verwendung
KR20150097764A (ko) 2012-12-21 2015-08-26 마이크로닉스 인코포레이티드. 휴대형 형광 검출 시스템 및 미량분석 카트리지
WO2014129292A1 (ja) * 2013-02-22 2014-08-28 株式会社 日立ハイテクノロジーズ 生体分析デバイスおよび生体分子分析装置
USD728120S1 (en) 2013-03-15 2015-04-28 Ventana Medical Systems, Inc. Arcuate member for moving liquids along a microscope slide
US10087440B2 (en) 2013-05-07 2018-10-02 Micronics, Inc. Device for preparation and analysis of nucleic acids
WO2014182831A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
EP3869257A1 (de) 2013-05-23 2021-08-25 S.D. Sight Diagnostics Ltd. Verfahren und system zur bildgebung einer zellprobe
WO2014205412A1 (en) 2013-06-21 2014-12-24 Intuity Medical, Inc. Analyte monitoring system with audible feedback
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for obtaining a monolayer of cells, for use specifically for diagnosis
US10082500B2 (en) 2013-08-22 2018-09-25 Franz Baudenbacher Device and method for detecting a target analyte
WO2015029032A1 (en) 2013-08-26 2015-03-05 Parasight Ltd. Digital microscopy systems, methods and computer program products
KR20150039051A (ko) * 2013-10-01 2015-04-09 삼성전자주식회사 혈액으로부터 혈장 또는 혈청을 분리하는 혈액 필터 장치 및 그의 용도
WO2015095239A1 (en) 2013-12-18 2015-06-25 Optiscan Biomedical Corporation Systems and methods for detecting leaks
US9891216B2 (en) 2014-04-02 2018-02-13 Chembio Diagnostic Systems, Inc. Immunoassay methods utilizing trapping conjugate
US10253357B2 (en) 2014-04-24 2019-04-09 Diassess Inc. Colorimetric detection of nucleic acid amplification
US10073091B2 (en) * 2014-08-08 2018-09-11 Ortho-Clinical Diagnostics, Inc. Lateral flow assay device
EP3186778B1 (de) 2014-08-27 2023-01-11 S.D. Sight Diagnostics Ltd. System und verfahren zur berechnung der fokusvariation für ein digitales mikroskop
US10175225B2 (en) 2014-09-29 2019-01-08 C A Casyso Ag Blood testing system and method
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
US10488644B2 (en) 2015-09-17 2019-11-26 S.D. Sight Diagnostics Ltd. Methods and apparatus for detecting an entity in a bodily sample
CN105628747B (zh) * 2015-12-18 2019-03-22 上海奥普生物医药有限公司 凝血时间测试分析装置及其测试分析方法
JP6949864B2 (ja) 2016-03-14 2021-10-13 ルシラ ヘルス インコーポレイテッド 生物学的アッセイ試料調製および送り出しのための装置および方法
WO2017160836A1 (en) 2016-03-14 2017-09-21 Diassess Inc. Systems and methods for performing biological assays
WO2017160839A1 (en) * 2016-03-14 2017-09-21 Diassess Inc. Devices and methods for modifying optical properties
EP3429543A4 (de) 2016-03-14 2019-11-06 Lucira Health, Inc. Selektiv belüftete biologische testvorrichtungen und zugehörige verfahren
US11733150B2 (en) 2016-03-30 2023-08-22 S.D. Sight Diagnostics Ltd. Distinguishing between blood sample components
EP3455610B1 (de) 2016-05-11 2023-01-04 S.D. Sight Diagnostics Ltd. Probenträger für optische messungen
CN115266540A (zh) 2016-05-11 2022-11-01 思迪赛特诊断有限公司 对样品实施的光学测量
KR101865055B1 (ko) * 2016-09-02 2018-06-08 (주)지엠에스바이오 혈당 측정용 스트립
US10172401B1 (en) * 2016-12-17 2019-01-08 Simple Texan Llc Backing plate for magnetic attachment
JP6941939B2 (ja) * 2016-12-22 2021-09-29 リンテック株式会社 検査部材、および検査部材の製造方法
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
CN110691972B (zh) 2017-04-20 2022-11-04 海默索尼克斯有限公司 用于止血功能分析的一次性系统
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
GB2569344A (en) * 2017-12-14 2019-06-19 Randox Laboratories Ltd Fluidic card assembly
USD910200S1 (en) 2018-12-21 2021-02-09 Lucira Health, Inc. Test tube
CN211905402U (zh) * 2019-11-22 2020-11-10 京东方科技集团股份有限公司 检测芯片及检测系统
CN110681297B (zh) * 2019-11-25 2023-05-30 徐州蓝湖信息科技有限公司 一种化工试剂制备扩散加速器
CN115349085A (zh) * 2020-03-24 2022-11-15 前沿诊疗股份有限公司 用于常规化学、免疫分析和核酸检测的临床分光光度计
US20230341672A1 (en) * 2020-04-24 2023-10-26 Leavitt Medical, Inc. D/B/A Lumea Focal plane spacers for microscope slides and related systems and methods
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
GB2622895A (en) * 2022-12-23 2024-04-03 Flexotronix Ltd Housing

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US27866A (en) * 1860-04-10 Improved mode of securing metal hoops on cotton-bales
US2616796A (en) * 1950-11-25 1952-11-04 Fred J Schilling Apparatus for determining a coagulation factor of blood samples
US3233975A (en) * 1962-03-05 1966-02-08 Ames Lab Tek Inc Prothrombin reaction chamber
GB1088421A (en) * 1964-01-07 1967-10-25 Harshaw Chemicals Ltd A method and apparatus for depositing a coating on the internal walls of capillary or smallbore tubes
US3395210A (en) * 1964-02-07 1968-07-30 Warner Lambert Pharmaceutical Lyophilized diagnostic reagent for the determination of blood coagulation factors
DE1617732C2 (de) * 1966-03-01 1972-12-21 Promoveo-Sobioda & Cie, Seyssinet (Frankreich) Vorrichtung zur Untersuchung lebender Zellen von Mikroorganismen
US3450501A (en) * 1966-03-28 1969-06-17 Bruce J Oberhardt Prothrombin time determination
US3520659A (en) * 1967-10-20 1970-07-14 Xerox Corp Method and apparatus for use in determining prothrombin time of a blood sample
US3635678A (en) * 1969-06-13 1972-01-18 Baxter Laboratories Inc Clot-timing system and method
BE759811A (fr) * 1969-12-04 1971-06-03 Technicon Instr Appareil de determination automatique des vitesses de coagulation, agglutination ou floculation de liquides, et agent renforcateur de reactionutilisable avec cet appareil
US3695842A (en) * 1970-03-12 1972-10-03 Intern Technidyne Corp Method and system for analyzing a liquid
US3691017A (en) * 1970-05-06 1972-09-12 Worthington Bio Chem Corp Means and method for chemical analysis
US3672351A (en) * 1970-08-17 1972-06-27 Richard W Ubersax Disposable blood test device
BE792113A (fr) * 1971-12-13 1973-05-30 Technicon Instr Melangeur de liquides contenant des particules magnetiques
US3861197A (en) * 1973-06-29 1975-01-21 Technicon Instr Method and apparatus for determining the viscosity of a liquid sample
US3880714A (en) * 1973-07-18 1975-04-29 Warner Lambert Co Diagnostic reagent
SE380100B (de) * 1974-02-07 1975-10-27 Monega Anstalt
US3918908A (en) * 1974-05-17 1975-11-11 Geomet Method for prothrombin testing
SE399768B (sv) * 1975-09-29 1978-02-27 Lilja Jan E Kyvett for provtagning, blandning av, provet med ett reagensmedel och direkt utforande av, serskilt optisk, analys av det med reagensmedlet blandade provet
US4097237A (en) * 1977-03-04 1978-06-27 Technicon Instruments Corporation Determination of cells in blood
US4176973A (en) * 1977-07-29 1979-12-04 Gregory Stephen A Stenotype tape marking attachment
JPS5469497A (en) * 1977-11-12 1979-06-04 Kyoto Daiichi Kagaku Kk Method and device for measuring blood solidification time
US4344438A (en) * 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
US4233029A (en) * 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4310399A (en) * 1979-07-23 1982-01-12 Eastman Kodak Company Liquid transport device containing means for delaying capillary flow
US4302313A (en) * 1979-07-23 1981-11-24 Eastman Kodak Company Electrode-containing device with capillary transport between electrodes
US4321057A (en) * 1979-09-20 1982-03-23 Buckles Richard G Method for quantitative analysis using optical fibers
US4323536A (en) * 1980-02-06 1982-04-06 Eastman Kodak Company Multi-analyte test device
US4413407A (en) * 1980-03-10 1983-11-08 Eastman Kodak Company Method for forming an electrode-containing device with capillary transport between electrodes
DE3029579C2 (de) * 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4391905A (en) * 1981-02-12 1983-07-05 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4391906A (en) * 1981-02-12 1983-07-05 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4340669A (en) * 1981-02-12 1982-07-20 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4473457A (en) * 1982-03-29 1984-09-25 Eastman Kodak Company Liquid transport device providing diversion of capillary flow into a non-vented second zone
DE3233809A1 (de) * 1982-09-11 1984-03-15 Boehringer Mannheim Gmbh, 6800 Mannheim Kuevette zur bestimmung chemischer verbindungen in fluessigkeiten
DE3247608A1 (de) * 1982-12-23 1984-07-05 Boehringer Mannheim Gmbh, 6800 Mannheim Teststreifen
US4558014A (en) * 1983-06-13 1985-12-10 Myron J. Block Assay apparatus and methods
IT1196349B (it) * 1983-12-02 1988-11-16 Vertrik Bioteknik Ab Dispositivo per le analisi chimiche ed impiego di esso
US4654127A (en) * 1984-04-11 1987-03-31 Sentech Medical Corporation Self-calibrating single-use sensing device for clinical chemistry and method of use
DE3582532D1 (de) * 1984-06-13 1991-05-23 Ares Serond Research & Dev Ltd Vorrichtungen zur verwendung in chemischen analyseverfahren.
US4596695A (en) * 1984-09-10 1986-06-24 Cottingham Hugh V Agglutinographic reaction chamber
US4826759A (en) * 1984-10-04 1989-05-02 Bio-Metric Systems, Inc. Field assay for ligands
US4678757A (en) * 1985-04-11 1987-07-07 Smithkline Diagnostics, Inc. Device and method for whole blood separation and analysis
FR2580407B1 (fr) * 1985-04-11 1987-06-26 Vieillard Didier Procede et appareil pour la mesure de la coagulation du plasma sanguin
DE3523439A1 (de) * 1985-06-29 1987-01-08 Boehringer Mannheim Gmbh Testtraeger
DE3523969A1 (de) * 1985-07-04 1987-01-08 Boehringer Mannheim Gmbh Gerinnungsneutrale, hydrophile glasfasern
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US4682895A (en) * 1985-08-06 1987-07-28 Texas A&M University Fiber optic probe for quantification of colorimetric reactions
US4761381A (en) * 1985-09-18 1988-08-02 Miles Inc. Volume metering capillary gap device for applying a liquid sample onto a reactive surface
US4712460A (en) * 1985-11-18 1987-12-15 Biotrack, Inc. Integrated drug dosage form and metering system
DE3616496A1 (de) * 1986-05-16 1987-11-19 Boehringer Mannheim Gmbh Analyseelement zur bestimmung von gerinnungsparametern
US4731330A (en) * 1986-07-01 1988-03-15 Biotrack, Inc. Whole blood control sample
US4753776A (en) * 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4789629A (en) * 1986-11-24 1988-12-06 Smithkline Beckman Corporation Method and device for collecting and testing for fecal occult blood
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US4912034A (en) * 1987-09-21 1990-03-27 Biogenex Laboratories Immunoassay test device and method
US4999163A (en) * 1987-10-29 1991-03-12 Hygeia Sciences, Inc. Disposable, pre-packaged device for conducting immunoassay procedures
US4818677A (en) * 1987-12-03 1989-04-04 Monoclonal Antibodies, Inc. Membrane assay using focused sample application

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10101576B4 (de) * 2001-01-15 2016-02-18 Presens Precision Sensing Gmbh Optischer Sensor und Sensorfeld
DE10140699A1 (de) * 2001-08-24 2003-03-13 Roche Diagnostics Gmbh Anordnung und Verfahren zur Untersuchung der Fließfähigkeit einer physiologischen Flüssigprobe
US6955923B2 (en) 2001-08-24 2005-10-18 Roche Diagnostics Operations, Inc. Device and method for investigating the flowability of a physiological fluid sample
DE10148210B4 (de) * 2001-09-28 2005-09-15 Ibidi Gmbh Flusskammer
US7517499B2 (en) 2001-09-28 2009-04-14 Ibidi Gmbh Flow chamber

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AU1591888A (en) 1988-11-02
CA1310566C (en) 1992-11-24
US4849340A (en) 1989-07-18
JP2736091B2 (ja) 1998-04-02
AU613623B2 (en) 1991-08-08
US6197494B1 (en) 2001-03-06
US20020119486A1 (en) 2002-08-29
ATE120543T1 (de) 1995-04-15
DE3853457D1 (de) 1995-05-04
EP0308494B1 (de) 1995-03-29
US5658723A (en) 1997-08-19
EP0308494A4 (de) 1990-07-04
WO1988007666A1 (en) 1988-10-06
EP0308494A1 (de) 1989-03-29
JPH01502797A (ja) 1989-09-28

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