JP6019485B2 - 血液濾過器具及び方法 - Google Patents
血液濾過器具及び方法 Download PDFInfo
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- JP6019485B2 JP6019485B2 JP2014500422A JP2014500422A JP6019485B2 JP 6019485 B2 JP6019485 B2 JP 6019485B2 JP 2014500422 A JP2014500422 A JP 2014500422A JP 2014500422 A JP2014500422 A JP 2014500422A JP 6019485 B2 JP6019485 B2 JP 6019485B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4005—Concentrating samples by transferring a selected component through a membrane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Sampling And Sample Adjustment (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
2 サンプル
3 メンブレン
4 キャリヤ
5 フルイディックシステム
6 カバー
7 受け入れチャネル
8 受け入れ開口部
9 隆起領域
10 環状領域
11 供給装置
12 供給開口部
13 供給部分
14 受け入れ装置
15 運搬装置
16 構造
17 突出部
18 チャネル
19 凹部
20 蓋
Claims (13)
- 液体サンプル(2)の濾過のための器具(1)であって、
前記サンプル(2)を濾過するメンブレン(3)を有し、
前記濾過されたサンプル(2)を受け入れるフルイディックシステム(5)を有し又は該フルイディックシステム(5)を形成するキャリヤ(4)を有する、器具において、
前記器具(1)は、前記濾過されたサンプル(2)が毛管力の結果として前記フルイディックシステム(5)に達し又は部分的にこれを充填した後でのみそれ以上の濾過又は前記濾過の促進のための負圧又は正圧を発生させる関連の運搬装置(15)を有し、
前記フルイディックシステム(5)は、前記濾過されたサンプル(2)を受け入れて排出するための前記メンブレン(3)の中央の下に配置された受け入れ開口部(8)を有し、
前記キャリヤ(4)は、前記メンブレン(3)に直接接触する隆起領域(9)を有し、
前記受け入れ開口部(8)は、前記キャリヤ(4)の前記隆起領域(9)内で前記メンブレン(3)に向かって開口する、ことを特徴とする器具。 - 前記器具は、前記キャリヤ(4)と関連したカバー(6)を有し、前記カバーは少なくとも部分的に前記フルイディックシステム(5)を覆い、かつ、前記メンブレン(3)の下で前記隆起領域(9)の周りに環状の当接領域を形成する、請求項1記載の器具。
- 前記受け入れ開口部(8)に隣接して受け入れチャネル(7)が設けられ、該受け入れチャネル(7)は、前記キャリヤ(4)に設けられた開口部によって形成された、請求項1記載の器具。
- 前記メンブレン(3)は、縁部のところで且つ/或いは円周方向に前記キャリヤ(4)に直接連結されると共に/或いは前記キャリヤ(3)の凹部(19)内に受け入れられている、請求項1記載の器具。
- 前記キャリヤ(4)は、前記メンブレン(3)の方へ向いていて、前記濾過されたサンプル(2)を前記受け入れ開口部(8)に供給する構造(16)を有する、請求項3又は4記載の器具。
- 前記メンブレン(3)は、前記サンプル(2)のための受け入れ装置(14)と一緒に該受け入れ装置に連結された状態で前記キャリヤ(4)又はそのカバー(6)上にルーズに載ると共に/或いはガス密状態で固定されてはいない、請求項1〜5のうちいずれか一に記載の器具。
- 前記器具(1)は、前記メンブレン(3)と毛管作用接触状態にある前記サンプル(2)の供給装置(11)を有する、請求項1〜6の何れか1項に記載の器具。
- 前記供給装置(11)は、漏斗形の形態のものである、請求項7に記載の器具。
- 前記供給装置(11)は、前記サンプル(2)のための受け入れ装置(14)内に配置され、前記メンブレン(3)は、その縁部のところで且つ/或いは円周方向に前記受け入れ装置(14)に連結されている、請求項7又は8に記載の器具。
- 液体サンプル(2)を濾過する方法であって、前記サンプル(2)をメンブレン(3)に通して濾過し、濾過された前記サンプル(2)を前記メンブレン(3)の平坦な側で排出してフルイディックシステム(5)に通す、方法において、
前記フルイディックシステム(5)は、前記メンブレン(3)と直接接触する隆起領域(9)を有するキャリヤ(4)により形成され、前記受け入れ開口部(8)は、前記隆起領域(9)内で前記メンブレン(3)に向かって開口し、
最初、前記濾過されたサンプル(2)が前記フルイディックシステム(5)に対し又は部分的にこれを充填するまで前記濾過を毛管力だけで又は毛管力を必要不可欠な手段として実施し、次に、負圧又は正圧を用いて前記濾過を続行し又は前記濾過を促進する、方法。 - 前記メンブレン(3)は、前記フルイディックシステム(5)を形成するキャリヤ(4)上又はそのカバー(6)上にルーズに載っていると共に/或いは縁部のところが非ガス密状態で固定されている、請求項10記載の方法。
- 前記負圧又は正圧は、最高100mPaに制限される、請求項10又は11記載の方法。
- 前記負圧又は正圧は、50mPaに制限される、請求項10又は11記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11002441.1 | 2011-03-24 | ||
EP11002441 | 2011-03-24 | ||
PCT/EP2012/055264 WO2012127050A2 (de) | 2011-03-24 | 2012-03-23 | Vorrichtung und verfahren zur filtration von blut |
Publications (2)
Publication Number | Publication Date |
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JP2014517909A JP2014517909A (ja) | 2014-07-24 |
JP6019485B2 true JP6019485B2 (ja) | 2016-11-02 |
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Application Number | Title | Priority Date | Filing Date |
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JP2014500422A Expired - Fee Related JP6019485B2 (ja) | 2011-03-24 | 2012-03-23 | 血液濾過器具及び方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US9182326B2 (ja) |
EP (1) | EP2688672A2 (ja) |
JP (1) | JP6019485B2 (ja) |
WO (1) | WO2012127050A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018176412A (ja) * | 2017-04-19 | 2018-11-15 | 天亮醫療器材股▲ふん▼有限公司SKYLA Corporation | 検出装置およびその注入口構造 |
Families Citing this family (15)
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US9182326B2 (en) | 2011-03-24 | 2015-11-10 | Boehringer Ingelheim Microparts Gmbh | Device and method for filtering blood |
DE102012015063B4 (de) * | 2012-07-31 | 2014-10-30 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren zur Behandlung eines Filtrationsmediums |
US9386948B2 (en) | 2012-12-05 | 2016-07-12 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample transport |
US10248765B1 (en) | 2012-12-05 | 2019-04-02 | Theranos Ip Company, Llc | Systems, devices, and methods for bodily fluid sample collection, transport, and handling |
US20140323911A1 (en) * | 2013-03-15 | 2014-10-30 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
JP2016512889A (ja) | 2013-03-15 | 2016-05-09 | セラノス, インコーポレイテッド | サンプルの収集およびサンプル分離の方法と機器 |
WO2016019113A1 (en) | 2014-08-01 | 2016-02-04 | Siemens Healthcare Diagnostics Inc. | Vacuum-assisted plasma separation |
CA2981990A1 (en) | 2015-04-09 | 2016-10-13 | Axela Inc. | Disposable bioassay cartridge and method of performing multiple assay steps and fluid transfer within the cartridge |
US10371606B2 (en) | 2015-07-21 | 2019-08-06 | Theraos IP Company, LLC | Bodily fluid sample collection and transport |
US11247208B2 (en) | 2015-09-09 | 2022-02-15 | Labrador Diagnostics Llc | Methods and devices for sample collection and sample separation |
JP2019520981A (ja) * | 2016-06-27 | 2019-07-25 | フルイディック・アナリティクス・リミテッド | マイクロ流体デバイスの改良またはマイクロ流体デバイスへの試料充填に関する改良 |
US20200009568A1 (en) * | 2016-12-13 | 2020-01-09 | Koninklijke Philips N.V. | Microfluidic device for accommodating, isolating, treating, and/or processing cells having an inlet chamber with a chute structure |
EP3576881A4 (en) | 2017-02-06 | 2019-12-25 | EFA - Engineering For All Ltd. | PORTABLE DIGITAL DIAGNOSTIC DEVICE |
US11857966B1 (en) | 2017-03-15 | 2024-01-02 | Labrador Diagnostics Llc | Methods and devices for sample collection and sample separation |
US11007526B2 (en) * | 2018-07-06 | 2021-05-18 | Qorvo Us, Inc. | Capless sample well port for a cartridge |
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US4849340A (en) * | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
US6540962B1 (en) | 1997-03-03 | 2003-04-01 | Kyoto Daiichi Kagaku Co., Ltd. | Testing instrument for analyzing liquid sample |
US6071294A (en) * | 1997-12-04 | 2000-06-06 | Agilent Technologies, Inc. | Lancet cartridge for sampling blood |
US7497994B2 (en) | 1998-02-24 | 2009-03-03 | Khushroo Gandhi | Microfluidic devices and systems incorporating cover layers |
US20030180711A1 (en) * | 2002-02-21 | 2003-09-25 | Turner Stephen W. | Three dimensional microfluidic device having porous membrane |
US7524462B2 (en) * | 2002-03-29 | 2009-04-28 | Agilent Technologies, Inc. | Capillary flow for a heterogenous assay in a micro-channel environment |
DE10252223A1 (de) | 2002-11-11 | 2004-05-27 | Roche Diagnostics Gmbh | Vorrichtung zur Separierung und Ausgabe von Plasma |
DE102004027422A1 (de) * | 2004-06-04 | 2005-12-29 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen |
BRPI0907148B1 (pt) | 2008-02-27 | 2021-01-12 | Boehringer Ingelheim Microparts Gmbh | dispositivo para a separação do plasma |
GB2463549B (en) * | 2008-07-15 | 2011-11-23 | L3 Technology Ltd | Assay device containing amphipathic polymers |
EP2473284A1 (en) * | 2009-09-01 | 2012-07-11 | Koninklijke Philips Electronics N.V. | Fluid filtering device |
WO2011027092A1 (en) * | 2009-09-01 | 2011-03-10 | F. Hoffmann-La Roche Ag | Micro-fluidic structures |
US9182326B2 (en) | 2011-03-24 | 2015-11-10 | Boehringer Ingelheim Microparts Gmbh | Device and method for filtering blood |
-
2012
- 2012-03-23 US US14/006,996 patent/US9182326B2/en not_active Expired - Fee Related
- 2012-03-23 EP EP12711625.9A patent/EP2688672A2/de not_active Withdrawn
- 2012-03-23 WO PCT/EP2012/055264 patent/WO2012127050A2/de active Application Filing
- 2012-03-23 JP JP2014500422A patent/JP6019485B2/ja not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018176412A (ja) * | 2017-04-19 | 2018-11-15 | 天亮醫療器材股▲ふん▼有限公司SKYLA Corporation | 検出装置およびその注入口構造 |
Also Published As
Publication number | Publication date |
---|---|
WO2012127050A2 (de) | 2012-09-27 |
WO2012127050A3 (de) | 2013-01-17 |
JP2014517909A (ja) | 2014-07-24 |
EP2688672A2 (de) | 2014-01-29 |
US20140134595A1 (en) | 2014-05-15 |
US9182326B2 (en) | 2015-11-10 |
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