DE3250034C2 - - Google Patents

Info

Publication number
DE3250034C2
DE3250034C2 DE3250034A DE3250034A DE3250034C2 DE 3250034 C2 DE3250034 C2 DE 3250034C2 DE 3250034 A DE3250034 A DE 3250034A DE 3250034 A DE3250034 A DE 3250034A DE 3250034 C2 DE3250034 C2 DE 3250034C2
Authority
DE
Germany
Prior art keywords
vitamin
calcium
hexafluoro
activity
acoet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3250034A
Other languages
German (de)
English (en)
Inventor
Hector F. Deluca
Yoko Madison Wis. Us Tanaka
Nobuo Musashino Tokio/Tokyo Jp Ikekawa
Yoshiro Shibuyaka Tokio/Tokyo Jp Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE3250034C2 publication Critical patent/DE3250034C2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE3250034A 1981-07-27 1982-07-06 Expired - Lifetime DE3250034C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same

Publications (1)

Publication Number Publication Date
DE3250034C2 true DE3250034C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-02-28

Family

ID=23100174

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3250034A Expired - Lifetime DE3250034C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-07-27 1982-07-06
DE823248900T Granted DE3248900T1 (de) 1981-07-27 1982-07-06 26,26,26,27,27,27-hexafluoro-1(alpha),25-dihydroxycholecalciferol und ein verfahren zu dessen herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE823248900T Granted DE3248900T1 (de) 1981-07-27 1982-07-06 26,26,26,27,27,27-hexafluoro-1(alpha),25-dihydroxycholecalciferol und ein verfahren zu dessen herstellung

Country Status (14)

Country Link
US (1) US4358406A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS58501176A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU552210B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE893943A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (2) CH656134A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3250034C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (2) DK162282C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2510566B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB2102806B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (2) IE54369B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (5) IL76090A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1157309B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8220265A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1983000335A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (en) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
CA1314872C (en) 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンd3のフッ素誘導体
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
AU5185790A (en) * 1989-02-16 1990-09-05 University Of Georgia Research Foundation, Inc., The Treatment of tibial dyschondroplasia
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
SK122593A3 (en) * 1991-05-06 1994-09-07 Procter & Gamble Additives containing calcium and vitamin d
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
CA2147264C (en) * 1992-10-16 2006-05-16 Tetsuhiro Mikami Vitamin d derivatives and a process for producing them
WO1994018985A1 (en) * 1993-02-19 1994-09-01 Wisconsin Alumni Research Foundation USE OF 26,26,26,27,27,27-HEXAFLUORO-1α,25-DIHYDROXYCHOLECALCIFEROL FOR THE TREATMENT OF CALCIUM METABOLISM DISORDERS
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
KR20010043558A (ko) 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
CA2710954C (en) * 2007-12-28 2015-07-21 Wisconsin Alumni Research Foundation (20s)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin d analogs
BRPI1007415A2 (pt) 2009-01-27 2016-02-16 Berg Biosystems Llc vitamina d3 e análogos da mesma para aliviar os efeitos colaterais associados com quimioterapia
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンd3およびその類似体
EP4245369A3 (en) * 2011-09-08 2023-11-22 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
ES2536256B2 (es) * 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
CA2991214C (en) 2015-07-06 2024-04-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MX392270B (es) 2016-09-30 2025-03-24 Sage Therapeutics Inc Oxisteroles sustituidos en c7 y metodos de uso de los mismos.
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Also Published As

Publication number Publication date
FR2510566A1 (fr) 1983-02-04
IL66351A0 (en) 1982-11-30
DK137083A (da) 1983-03-25
CH656134A5 (de) 1986-06-13
IL76091A (en) 1987-12-31
FR2510566B1 (fr) 1985-06-28
DK165695B (da) 1993-01-04
JPH0348903B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-07-25
WO1983000335A1 (en) 1983-02-03
DE3248900C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-12-13
IL76091A0 (en) 1985-12-31
IL76090A0 (en) 1985-12-31
GB2118556B (en) 1985-02-27
DK554084A (da) 1984-11-22
IT8222574A0 (it) 1982-07-26
AU552210B2 (en) 1986-05-22
AU6056086A (en) 1986-12-18
AU586267B2 (en) 1989-07-06
IL76090A (en) 1987-12-31
DK162282B (da) 1991-10-07
IE54369B1 (en) 1989-09-13
IE821797L (en) 1983-01-27
GB2102806B (en) 1985-02-27
GB2118556A (en) 1983-11-02
IT1157309B (it) 1987-02-11
DE3248900T1 (de) 1983-07-07
DK137083D0 (da) 1983-03-25
BE893943A (fr) 1982-11-16
US4358406A (en) 1982-11-09
GB8311517D0 (en) 1983-06-02
IE54370B1 (en) 1989-09-13
AU8760582A (en) 1983-03-17
DK162282C (da) 1992-03-16
DK165695C (da) 1993-06-07
DK554084D0 (da) 1984-11-22
NL8220265A (nl) 1983-06-01
JPS58501176A (ja) 1983-07-21
IE891226L (en) 1983-01-27
GB2102806A (en) 1983-02-09
CH655307A5 (de) 1986-04-15
IL66351A (en) 1987-12-31

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