JPH0348903B2 - - Google Patents

Info

Publication number
JPH0348903B2
JPH0348903B2 JP57502411A JP50241182A JPH0348903B2 JP H0348903 B2 JPH0348903 B2 JP H0348903B2 JP 57502411 A JP57502411 A JP 57502411A JP 50241182 A JP50241182 A JP 50241182A JP H0348903 B2 JPH0348903 B2 JP H0348903B2
Authority
JP
Japan
Prior art keywords
vitamin
hexafluoro
calcium
activity
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57502411A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58501176A (ja
Inventor
Hekutaa Efu Deruuka
Yoko Tanaka
Nobuo Ikegawa
Yoshiro Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UISUKONSHIN ARAMUNI RISAACHI FUAUNDEESHON
Original Assignee
UISUKONSHIN ARAMUNI RISAACHI FUAUNDEESHON
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UISUKONSHIN ARAMUNI RISAACHI FUAUNDEESHON filed Critical UISUKONSHIN ARAMUNI RISAACHI FUAUNDEESHON
Publication of JPS58501176A publication Critical patent/JPS58501176A/ja
Publication of JPH0348903B2 publication Critical patent/JPH0348903B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP57502411A 1981-07-27 1982-07-06 ２６，２６，２６，２７，２７，２７−ヘキサフルオロ−１α，２５−ジヒドロキシコレカルシフエロ−ル及びその調製方法 Granted JPS58501176A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US286790 1981-07-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP3015748A Division JPH0737476B2 (ja) 1991-01-17 1991-01-17 ２６，２６，２６，２７，２７，２７−ヘキサフルオロ−１α，２５−ジヒドロキシコレステロール

Publications (2)

Publication Number Publication Date
JPS58501176A JPS58501176A (ja) 1983-07-21
JPH0348903B2 true JPH0348903B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-07-25

Family

ID=23100174

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57502411A Granted JPS58501176A (ja) 1981-07-27 1982-07-06 ２６，２６，２６，２７，２７，２７−ヘキサフルオロ−１α，２５−ジヒドロキシコレカルシフエロ−ル及びその調製方法

Country Status (14)

Country Link
US (1) US4358406A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS58501176A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU552210B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE893943A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (2) CH656134A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3250034C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (2) DK162282C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2510566B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB2102806B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (2) IE54370B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (5) IL76090A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1157309B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8220265A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1983000335A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (en) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
CA1314872C (en) 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
EP0583378B1 (en) * 1991-05-06 2003-11-12 The Procter & Gamble Company Combined calcium and vitamin d supplements
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
US5726330A (en) * 1992-10-16 1998-03-10 Chugai Seiyaku Kabushiki Kaisha Highly crystalline 22-oxavitamin D derivatives
JPH08507073A (ja) * 1993-02-19 1996-07-30 ウイスコンシン アラムナイ リサーチ フオンデーシヨン カルシウム代謝障害の治療のための２６，２６，２６，２７，２７，２７−ヘキサフルオロ−１アルファ，２５−ジヒドロキシコレカルシフェロールの使用
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
IL139241A0 (en) 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
MX2010007266A (es) * 2007-12-28 2010-11-30 Wisconsin Alumni Res Found Análogos de vitamina d, (20s)-23, 23-difluoro-2-metilen-19-nor-bis homopregnacalciferol.
CA2981549A1 (en) 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
BR112012003372A2 (pt) 2009-08-14 2019-09-24 Berg Biosystems Llc vitamina d3 e análogos da mesma para o tratamento de alopecia.
SI2753632T1 (sl) * 2011-09-08 2023-08-31 Sage Therapeutics, Inc. Nevroaktivni steroidi, njihovi sestavki in uporaba
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
ES2536256B2 (es) * 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
SG10202010553XA (en) 2015-07-06 2020-12-30 Sage Therapeutics Inc Oxysterols and methods of use thereof
CA3038900A1 (en) 2016-09-30 2018-04-05 Sage Therapeutics, Inc. C7 substituted oxysterols and methods as nmda modulators
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Also Published As

Publication number Publication date
WO1983000335A1 (en) 1983-02-03
DK162282B (da) 1991-10-07
FR2510566A1 (fr) 1983-02-04
GB2118556B (en) 1985-02-27
GB2102806B (en) 1985-02-27
IL76090A0 (en) 1985-12-31
GB2118556A (en) 1983-11-02
IT8222574A0 (it) 1982-07-26
IE891226L (en) 1983-01-27
AU552210B2 (en) 1986-05-22
FR2510566B1 (fr) 1985-06-28
GB8311517D0 (en) 1983-06-02
DE3250034C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-02-28
DK137083A (da) 1983-03-25
DK137083D0 (da) 1983-03-25
IL76091A (en) 1987-12-31
DK165695B (da) 1993-01-04
IL76091A0 (en) 1985-12-31
IT1157309B (it) 1987-02-11
IL66351A0 (en) 1982-11-30
CH655307A5 (de) 1986-04-15
AU8760582A (en) 1983-03-17
AU6056086A (en) 1986-12-18
AU586267B2 (en) 1989-07-06
GB2102806A (en) 1983-02-09
US4358406A (en) 1982-11-09
DK554084A (da) 1984-11-22
DE3248900C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-12-13
IE821797L (en) 1983-01-27
IE54370B1 (en) 1989-09-13
IL76090A (en) 1987-12-31
BE893943A (fr) 1982-11-16
NL8220265A (nl) 1983-06-01
DK165695C (da) 1993-06-07
CH656134A5 (de) 1986-06-13
JPS58501176A (ja) 1983-07-21
DK554084D0 (da) 1984-11-22
IE54369B1 (en) 1989-09-13
DK162282C (da) 1992-03-16
DE3248900T1 (de) 1983-07-07
IL66351A (en) 1987-12-31

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