JPS58501176A - 26,26,26,27,27,27−ヘキサフルオロ−1α,25−ジヒドロキシコレカルシフエロ−ル及びその調製方法 - Google Patents

26,26,26,27,27,27−ヘキサフルオロ−1α,25−ジヒドロキシコレカルシフエロ−ル及びその調製方法

Info

Publication number
JPS58501176A
JPS58501176A JP57502411A JP50241182A JPS58501176A JP S58501176 A JPS58501176 A JP S58501176A JP 57502411 A JP57502411 A JP 57502411A JP 50241182 A JP50241182 A JP 50241182A JP S58501176 A JPS58501176 A JP S58501176A
Authority
JP
Japan
Prior art keywords
hexafluoro
triacetate
hydroxy
vitamin
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57502411A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0348903B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
デル−カ・ヘクタ−・エフ
洋子 田中
池川 信夫
小林 義郎
Original Assignee
ウイスコンシン アラムナイ リサ−チ フオンデ−シヨン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウイスコンシン アラムナイ リサ−チ フオンデ−シヨン filed Critical ウイスコンシン アラムナイ リサ−チ フオンデ−シヨン
Publication of JPS58501176A publication Critical patent/JPS58501176A/ja
Publication of JPH0348903B2 publication Critical patent/JPH0348903B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP57502411A 1981-07-27 1982-07-06 26,26,26,27,27,27−ヘキサフルオロ−1α,25−ジヒドロキシコレカルシフエロ−ル及びその調製方法 Granted JPS58501176A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US286790 1981-07-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP3015748A Division JPH0737476B2 (ja) 1991-01-17 1991-01-17 26,26,26,27,27,27−ヘキサフルオロ−1α,25−ジヒドロキシコレステロール

Publications (2)

Publication Number Publication Date
JPS58501176A true JPS58501176A (ja) 1983-07-21
JPH0348903B2 JPH0348903B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-07-25

Family

ID=23100174

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57502411A Granted JPS58501176A (ja) 1981-07-27 1982-07-06 26,26,26,27,27,27−ヘキサフルオロ−1α,25−ジヒドロキシコレカルシフエロ−ル及びその調製方法

Country Status (14)

Country Link
US (1) US4358406A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS58501176A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU552210B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE893943A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (2) CH655307A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3250034C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (2) DK162282C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2510566B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB2102806B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (2) IE54370B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (5) IL66351A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1157309B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8220265A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1983000335A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0250755A2 (en) 1986-04-25 1988-01-07 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
WO1994008958A1 (en) * 1992-10-16 1994-04-28 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivative and process for producing the same

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (en) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンd3のフッ素誘導体
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
AU5185790A (en) * 1989-02-16 1990-09-05 University Of Georgia Research Foundation, Inc., The Treatment of tibial dyschondroplasia
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
AU666313B2 (en) * 1991-05-06 1996-02-08 Procter & Gamble Company, The Combined calcium and vitamin D supplements
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
JPH08507073A (ja) * 1993-02-19 1996-07-30 ウイスコンシン アラムナイ リサーチ フオンデーシヨン カルシウム代謝障害の治療のための26,26,26,27,27,27−ヘキサフルオロ−1アルファ,25−ジヒドロキシコレカルシフェロールの使用
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
KR20010043558A (ko) * 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
JP2011508743A (ja) * 2007-12-28 2011-03-17 ウィスコンシン アラムナイ リサーチ ファンデーション (20s)−23,23−ジフルオロ−2−メチレン−19−ノル−ビスホモプレグナカルシフェロール−ビタミンd類縁体
JP5932339B2 (ja) 2009-01-27 2016-06-08 バーグ エルエルシー 化学療法に付随する副作用を軽減するためのビタミンd3およびその類似体
BR112012003372A2 (pt) 2009-08-14 2019-09-24 Berg Biosystems Llc vitamina d3 e análogos da mesma para o tratamento de alopecia.
FI2753632T3 (fi) * 2011-09-08 2023-08-02 Sage Therapeutics Inc Neuroaktiivisia steroideja, koostumuksia ja niiden käyttöjä
CN105492081A (zh) 2013-05-29 2016-04-13 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
ES2536256B2 (es) * 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
HRP20210526T8 (hr) 2015-07-06 2021-08-20 Sage Therapeutics, Inc. Oksisteroli i postupci za njihovu uporabu
MX392270B (es) 2016-09-30 2025-03-24 Sage Therapeutics Inc Oxisteroles sustituidos en c7 y metodos de uso de los mismos.
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0250755A2 (en) 1986-04-25 1988-01-07 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
WO1994008958A1 (en) * 1992-10-16 1994-04-28 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivative and process for producing the same

Also Published As

Publication number Publication date
NL8220265A (nl) 1983-06-01
IL76091A (en) 1987-12-31
CH656134A5 (de) 1986-06-13
IE54369B1 (en) 1989-09-13
IL66351A (en) 1987-12-31
DK137083D0 (da) 1983-03-25
WO1983000335A1 (en) 1983-02-03
BE893943A (fr) 1982-11-16
DE3248900C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-12-13
IE891226L (en) 1983-01-27
DK554084D0 (da) 1984-11-22
AU586267B2 (en) 1989-07-06
IT8222574A0 (it) 1982-07-26
AU6056086A (en) 1986-12-18
IL66351A0 (en) 1982-11-30
GB2118556B (en) 1985-02-27
CH655307A5 (de) 1986-04-15
IT1157309B (it) 1987-02-11
GB2118556A (en) 1983-11-02
DK554084A (da) 1984-11-22
IL76090A0 (en) 1985-12-31
DE3248900T1 (de) 1983-07-07
GB2102806A (en) 1983-02-09
GB2102806B (en) 1985-02-27
DK162282C (da) 1992-03-16
DK165695C (da) 1993-06-07
DK165695B (da) 1993-01-04
JPH0348903B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-07-25
IL76090A (en) 1987-12-31
IE821797L (en) 1983-01-27
IL76091A0 (en) 1985-12-31
US4358406A (en) 1982-11-09
DK162282B (da) 1991-10-07
DE3250034C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-02-28
FR2510566A1 (fr) 1983-02-04
GB8311517D0 (en) 1983-06-02
AU552210B2 (en) 1986-05-22
AU8760582A (en) 1983-03-17
IE54370B1 (en) 1989-09-13
FR2510566B1 (fr) 1985-06-28
DK137083A (da) 1983-03-25

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