DE3153666C2 - Monacolinderivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende Arzneimittel - Google Patents

Monacolinderivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende Arzneimittel

Info

Publication number
DE3153666C2
DE3153666C2 DE3153666A DE3153666A DE3153666C2 DE 3153666 C2 DE3153666 C2 DE 3153666C2 DE 3153666 A DE3153666 A DE 3153666A DE 3153666 A DE3153666 A DE 3153666A DE 3153666 C2 DE3153666 C2 DE 3153666C2
Authority
DE
Germany
Prior art keywords
group
bis
branched
chain
straight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3153666A
Other languages
German (de)
English (en)
Inventor
Aiya Dr Sato
Akira Dr Terahara
Yoshio Dr Tsujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12604367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3153666(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE3153666C2 publication Critical patent/DE3153666C2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE3153666A 1980-03-31 1981-03-30 Monacolinderivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende Arzneimittel Expired - Lifetime DE3153666C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55041292A JPH0692381B2 (ja) 1980-03-31 1980-03-31 Ｍｂ−５３０ａ誘導体

Publications (1)

Publication Number Publication Date
DE3153666C2 true DE3153666C2 (de) 1993-11-11

Family

ID=12604367

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3153666A Expired - Lifetime DE3153666C2 (de) 1980-03-31 1981-03-30 Monacolinderivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende Arzneimittel
DE19813112566 Granted DE3112566A1 (de) 1980-03-31 1981-03-30 Monacolin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19813112566 Granted DE3112566A1 (de) 1980-03-31 1981-03-30 Monacolin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel

Country Status (15)

Country Link
JP (1) JPH0692381B2 (enrdf_load_stackoverflow)
AT (1) ATA150781A (enrdf_load_stackoverflow)
AU (1) AU6893281A (enrdf_load_stackoverflow)
BE (1) BE888214A (enrdf_load_stackoverflow)
CH (1) CH646966A5 (enrdf_load_stackoverflow)
DE (2) DE3153666C2 (enrdf_load_stackoverflow)
DK (3) DK151273C (enrdf_load_stackoverflow)
FI (1) FI810991L (enrdf_load_stackoverflow)
FR (1) FR2479222A1 (enrdf_load_stackoverflow)
GB (1) GB2073193A (enrdf_load_stackoverflow)
IE (1) IE52367B1 (enrdf_load_stackoverflow)
IT (1) IT1144325B (enrdf_load_stackoverflow)
MX (1) MX9203567A (enrdf_load_stackoverflow)
NL (1) NL8101592A (enrdf_load_stackoverflow)
SE (1) SE461590B (enrdf_load_stackoverflow)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472426A (en) * 1982-12-22 1984-09-18 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0215665B1 (en) * 1985-09-13 1991-11-21 Sankyo Company Limited Hydroxy-ml-236b derivatives, their preparation and use
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5075327A (en) * 1988-08-10 1991-12-24 Hoffmann-La Roche Inc. Antipsoriatic agents
US5073568A (en) * 1988-11-14 1991-12-17 Hoffmann-La Roche Inc. Antipsoriatic agents
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5200549A (en) * 1988-11-14 1993-04-06 Hoffman-La Roche Inc. Antipsoriatic agents
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
FR2937537A1 (fr) * 2008-10-29 2010-04-30 Centre Nat Rech Scient Nanoparticules de statine
KR101820099B1 (ko) 2013-01-18 2018-01-18 에스프린팅솔루션 주식회사 저항 발열체, 이를 채용한 가열 부재, 및 정착 장치
CA3087932A1 (en) * 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983140A (en) * 1974-06-07 1976-09-28 Sankyo Company Limited Physiologically active substances
EP0033538A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. 6(R)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
ZA81703B (en) * 1980-02-04 1982-09-29 Merck & Co Inc New antihypercholesterolemic compounds,intermediates and processes
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983140A (en) * 1974-06-07 1976-09-28 Sankyo Company Limited Physiologically active substances
EP0033538A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. 6(R)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same

Also Published As

Publication number Publication date
ATA150781A (de) 1983-03-15
IT1144325B (it) 1986-10-29
DK151273C (da) 1988-07-04
FI810991A7 (fi) 1981-10-01
FR2479222A1 (fr) 1981-10-02
FI810991L (fi) 1981-10-01
FR2479222B1 (enrdf_load_stackoverflow) 1983-08-26
DK32290D0 (da) 1990-02-07
IE52367B1 (en) 1987-09-30
DE3112566C2 (enrdf_load_stackoverflow) 1990-04-05
NL8101592A (nl) 1981-10-16
IE810698L (en) 1981-09-30
DK32190A (da) 1990-02-07
DK32190D0 (da) 1990-02-07
CH646966A5 (de) 1984-12-28
IT8167438A0 (it) 1981-03-30
SE461590B (sv) 1990-03-05
BE888214A (fr) 1981-09-30
DK145481A (da) 1981-10-01
JPH0692381B2 (ja) 1994-11-16
DK167805B1 (da) 1993-12-20
GB2073193A (en) 1981-10-14
AU6893281A (en) 1981-10-08
SE8102047L (sv) 1981-10-01
MX9203567A (es) 1992-09-01
DK151273B (da) 1987-11-16
JPS56138181A (en) 1981-10-28
DE3112566A1 (de) 1982-03-11
DK32290A (da) 1990-02-07

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