FR2479222A1 - Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol, leur procede de preparation et leur application en therapeutique - Google Patents

Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol, leur procede de preparation et leur application en therapeutique Download PDF

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Publication number
FR2479222A1
FR2479222A1 FR8106403A FR8106403A FR2479222A1 FR 2479222 A1 FR2479222 A1 FR 2479222A1 FR 8106403 A FR8106403 A FR 8106403A FR 8106403 A FR8106403 A FR 8106403A FR 2479222 A1 FR2479222 A1 FR 2479222A1
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FR
France
Prior art keywords
group
bis
compounds according
hydrogen atom
multiplet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8106403A
Other languages
English (en)
French (fr)
Other versions
FR2479222B1 (enrdf_load_stackoverflow
Inventor
Aiya Sato
Akira Terahara
Yoshio Tsujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12604367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2479222(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of FR2479222A1 publication Critical patent/FR2479222A1/fr
Application granted granted Critical
Publication of FR2479222B1 publication Critical patent/FR2479222B1/fr
Granted legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR8106403A 1980-03-31 1981-03-31 Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol, leur procede de preparation et leur application en therapeutique Granted FR2479222A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55041292A JPH0692381B2 (ja) 1980-03-31 1980-03-31 Ｍｂ−５３０ａ誘導体

Publications (2)

Publication Number Publication Date
FR2479222A1 true FR2479222A1 (fr) 1981-10-02
FR2479222B1 FR2479222B1 (enrdf_load_stackoverflow) 1983-08-26

Family

ID=12604367

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8106403A Granted FR2479222A1 (fr) 1980-03-31 1981-03-31 Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol, leur procede de preparation et leur application en therapeutique

Country Status (15)

Country Link
JP (1) JPH0692381B2 (enrdf_load_stackoverflow)
AT (1) ATA150781A (enrdf_load_stackoverflow)
AU (1) AU6893281A (enrdf_load_stackoverflow)
BE (1) BE888214A (enrdf_load_stackoverflow)
CH (1) CH646966A5 (enrdf_load_stackoverflow)
DE (2) DE3112566A1 (enrdf_load_stackoverflow)
DK (3) DK151273C (enrdf_load_stackoverflow)
FI (1) FI810991L (enrdf_load_stackoverflow)
FR (1) FR2479222A1 (enrdf_load_stackoverflow)
GB (1) GB2073193A (enrdf_load_stackoverflow)
IE (1) IE52367B1 (enrdf_load_stackoverflow)
IT (1) IT1144325B (enrdf_load_stackoverflow)
MX (1) MX9203567A (enrdf_load_stackoverflow)
NL (1) NL8101592A (enrdf_load_stackoverflow)
SE (1) SE461590B (enrdf_load_stackoverflow)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472426A (en) * 1982-12-22 1984-09-18 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0215665B1 (en) * 1985-09-13 1991-11-21 Sankyo Company Limited Hydroxy-ml-236b derivatives, their preparation and use
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5075327A (en) * 1988-08-10 1991-12-24 Hoffmann-La Roche Inc. Antipsoriatic agents
US5073568A (en) * 1988-11-14 1991-12-17 Hoffmann-La Roche Inc. Antipsoriatic agents
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5200549A (en) * 1988-11-14 1993-04-06 Hoffman-La Roche Inc. Antipsoriatic agents
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
FR2937537A1 (fr) * 2008-10-29 2010-04-30 Centre Nat Rech Scient Nanoparticules de statine
KR101820099B1 (ko) 2013-01-18 2018-01-18 에스프린팅솔루션 주식회사 저항 발열체, 이를 채용한 가열 부재, 및 정착 장치
WO2019139919A1 (en) * 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983140A (en) * 1974-06-07 1976-09-28 Sankyo Company Limited Physiologically active substances
FR2449685A1 (fr) * 1979-02-20 1980-09-19 Sankyo Co Agent antihypercholesterolemique prepare par culture de microorganismes du genre monascus et son procede de preparation
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR69216B (enrdf_load_stackoverflow) * 1979-06-15 1982-05-07 Merck & Co Inc
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
ZA81703B (en) * 1980-02-04 1982-09-29 Merck & Co Inc New antihypercholesterolemic compounds,intermediates and processes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983140A (en) * 1974-06-07 1976-09-28 Sankyo Company Limited Physiologically active substances
FR2449685A1 (fr) * 1979-02-20 1980-09-19 Sankyo Co Agent antihypercholesterolemique prepare par culture de microorganismes du genre monascus et son procede de preparation
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation

Also Published As

Publication number Publication date
DK151273B (da) 1987-11-16
CH646966A5 (de) 1984-12-28
FI810991A7 (fi) 1981-10-01
FI810991L (fi) 1981-10-01
DK32290A (da) 1990-02-07
BE888214A (fr) 1981-09-30
IE52367B1 (en) 1987-09-30
FR2479222B1 (enrdf_load_stackoverflow) 1983-08-26
AU6893281A (en) 1981-10-08
IT1144325B (it) 1986-10-29
DK145481A (da) 1981-10-01
DK32190D0 (da) 1990-02-07
GB2073193A (en) 1981-10-14
IT8167438A0 (it) 1981-03-30
ATA150781A (de) 1983-03-15
SE461590B (sv) 1990-03-05
IE810698L (en) 1981-09-30
DE3153666C2 (de) 1993-11-11
DE3112566C2 (enrdf_load_stackoverflow) 1990-04-05
JPS56138181A (en) 1981-10-28
DE3112566A1 (de) 1982-03-11
NL8101592A (nl) 1981-10-16
DK32290D0 (da) 1990-02-07
DK32190A (da) 1990-02-07
DK151273C (da) 1988-07-04
JPH0692381B2 (ja) 1994-11-16
SE8102047L (sv) 1981-10-01
MX9203567A (es) 1992-09-01
DK167805B1 (da) 1993-12-20

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