DE69717530T2 - Verfahren zur Herstellung von Lipstatin und Tetrahydrolipstatin - Google Patents

Verfahren zur Herstellung von Lipstatin und Tetrahydrolipstatin

Info

Publication number
DE69717530T2
DE69717530T2 DE69717530T DE69717530T DE69717530T2 DE 69717530 T2 DE69717530 T2 DE 69717530T2 DE 69717530 T DE69717530 T DE 69717530T DE 69717530 T DE69717530 T DE 69717530T DE 69717530 T2 DE69717530 T2 DE 69717530T2
Authority
DE
Germany
Prior art keywords
lipstatin
tetrahydrolipstatin
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69717530T
Other languages
English (en)
Other versions
DE69717530D1 (de
Inventor
Adelbert Bacher
Peter Stohler
Wolfgang Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69717530D1 publication Critical patent/DE69717530D1/de
Application granted granted Critical
Publication of DE69717530T2 publication Critical patent/DE69717530T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69717530T 1996-04-26 1997-04-18 Verfahren zur Herstellung von Lipstatin und Tetrahydrolipstatin Expired - Lifetime DE69717530T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96106598 1996-04-26

Publications (2)

Publication Number Publication Date
DE69717530D1 DE69717530D1 (de) 2003-01-16
DE69717530T2 true DE69717530T2 (de) 2003-11-06

Family

ID=8222717

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69717530T Expired - Lifetime DE69717530T2 (de) 1996-04-26 1997-04-18 Verfahren zur Herstellung von Lipstatin und Tetrahydrolipstatin

Country Status (15)

Country Link
US (1) US20020110873A1 (de)
EP (1) EP0803576B1 (de)
JP (1) JP4094698B2 (de)
CN (1) CN1128224C (de)
AR (1) AR006831A1 (de)
AT (1) ATE229077T1 (de)
BR (1) BR9701953A (de)
CA (1) CA2202016C (de)
DE (1) DE69717530T2 (de)
DK (1) DK0803576T3 (de)
ES (1) ES2186818T3 (de)
ID (1) ID16410A (de)
MY (1) MY116591A (de)
PT (1) PT803576E (de)
TR (1) TR199700289A3 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1028115T3 (da) * 1999-01-29 2003-03-17 Hoffmann La Roche Oprensning af lipstatin
AU2002235885A1 (en) * 2001-02-09 2002-08-28 Unilever N.V. Process for the preparation of one or more statins by fermentation
WO2003048335A2 (en) * 2001-12-04 2003-06-12 Biogal Gyogyszergyar Rt A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth
US6734314B2 (en) * 2001-12-04 2004-05-11 Biogal Gyogyszergyar Rt. Preparation of orlistat and orlistat crystalline forms
AU2003253254A1 (en) * 2003-07-17 2005-02-04 Biocon Limited Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification
SK22006A3 (sk) * 2006-01-03 2007-08-02 Biotika, A. S. Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom
EP1860194A1 (de) * 2006-05-22 2007-11-28 KRKA, tovarna zdravil, d.d., Novo mesto Fermentative Herstellung von Lipstatin
WO2009040827A1 (en) * 2007-09-24 2009-04-02 Biocon Limited A process for obtaining tetrahydrolipstatin
JP2011515100A (ja) * 2008-03-26 2011-05-19 バイオコン リミテッド 消費脂肪酸に対して高い収率係数のリパーゼ阻害剤を得る改善された発酵プロセス
CN102268466B (zh) * 2011-07-23 2013-06-12 鲁南新时代生物技术有限公司 一种发酵生产利普司他汀的方法及其培养基组份
CN103820510B (zh) * 2014-01-17 2016-01-20 浙江工业大学 一种微生物发酵生产利普司他汀的方法及培养基

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247547A (en) * 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives
CH675966A5 (de) 1987-02-20 1990-11-30 Firmenich & Cie
CA2098167C (en) * 1992-06-24 2006-12-19 Dorothea Isler Foodstuffs and feedstuffs containing a lipase inhibitor

Also Published As

Publication number Publication date
MX9703057A (es) 1998-06-30
DE69717530D1 (de) 2003-01-16
MY116591A (en) 2004-02-28
CN1170761A (zh) 1998-01-21
BR9701953A (pt) 1998-09-15
JPH1066592A (ja) 1998-03-10
ATE229077T1 (de) 2002-12-15
EP0803576B1 (de) 2002-12-04
US20020110873A1 (en) 2002-08-15
CA2202016A1 (en) 1997-10-26
EP0803576A2 (de) 1997-10-29
ID16410A (id) 1997-10-30
ES2186818T3 (es) 2003-05-16
EP0803576A3 (de) 1999-04-21
CN1128224C (zh) 2003-11-19
JP4094698B2 (ja) 2008-06-04
PT803576E (pt) 2003-03-31
TR199700289A2 (en) 1997-11-21
AR006831A1 (es) 1999-09-29
CA2202016C (en) 2009-12-08
TR199700289A3 (tr) 1997-11-21
DK0803576T3 (da) 2003-03-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition