DK1028115T3 - Oprensning af lipstatin - Google Patents

Oprensning af lipstatin

Info

Publication number
DK1028115T3
DK1028115T3 DK00101141T DK00101141T DK1028115T3 DK 1028115 T3 DK1028115 T3 DK 1028115T3 DK 00101141 T DK00101141 T DK 00101141T DK 00101141 T DK00101141 T DK 00101141T DK 1028115 T3 DK1028115 T3 DK 1028115T3
Authority
DK
Denmark
Prior art keywords
lipstatin
purification
extraction
relates
liquid
Prior art date
Application number
DK00101141T
Other languages
English (en)
Inventor
Stephan Doswald
Ernst Kupfer
Gerhard Steinbauer
Erich Steinwender
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1028115T3 publication Critical patent/DK1028115T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK00101141T 1999-01-29 2000-01-21 Oprensning af lipstatin DK1028115T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99101893 1999-01-29

Publications (1)

Publication Number Publication Date
DK1028115T3 true DK1028115T3 (da) 2003-03-17

Family

ID=8237471

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00101141T DK1028115T3 (da) 1999-01-29 2000-01-21 Oprensning af lipstatin

Country Status (10)

Country Link
US (1) US6156911A (da)
EP (1) EP1028115B1 (da)
JP (1) JP3445209B2 (da)
KR (1) KR100336237B1 (da)
CN (1) CN100363354C (da)
AT (1) ATE228118T1 (da)
CA (1) CA2296996C (da)
DE (1) DE60000796T2 (da)
DK (1) DK1028115T3 (da)
ES (1) ES2185523T3 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6734314B2 (en) * 2001-12-04 2004-05-11 Biogal Gyogyszergyar Rt. Preparation of orlistat and orlistat crystalline forms
AU2003253254A1 (en) * 2003-07-17 2005-02-04 Biocon Limited Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification
PT1673359E (pt) * 2003-09-12 2009-10-06 Ranbaxy Lab Ltd Processo para a preparação de formas cristalinas de orlistat
FR2861990B1 (fr) * 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
CN1763021B (zh) * 2005-09-29 2010-08-11 杭州华东医药集团生物工程研究所有限公司 一种提纯奥利司他的方法
EP1803714A1 (en) 2005-12-27 2007-07-04 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing crystalline forms of orlistat
US20080021092A1 (en) * 2006-01-06 2008-01-24 Deepak Murpani Stable pharmaceutical compositions of orlistat
WO2009039157A2 (en) * 2007-09-17 2009-03-26 Dr. Reddy's Laboratories Ltd. Orlistat pharmaceutical formulations
US20120083629A1 (en) 2009-06-15 2012-04-05 Daikin Industries, Ltd. Method for producing fluorine-containing ether with high purity
CN101948450B (zh) * 2010-10-13 2013-04-24 鲁南制药集团股份有限公司 一种生产制备奥利司他的方法
CN102558103B (zh) * 2010-12-13 2015-01-14 山东新时代药业有限公司 一种分离和纯化奥利司他的方法
CN103030613B (zh) * 2011-09-29 2014-11-12 北大方正集团有限公司 一种利普司他汀的提纯方法
US20150099800A1 (en) * 2012-05-24 2015-04-09 Northeastern University Novel lipase inhibitors, reporter substrates and uses thereof
CN103420953B (zh) * 2013-07-19 2015-10-21 杭州华东医药集团新药研究院有限公司 一种提纯奥利司他中间体的方法
CN103992297B (zh) * 2014-06-06 2016-04-13 鲁南制药集团股份有限公司 一种利普司他汀的制备方法
CN103992296B (zh) * 2014-06-06 2015-08-05 鲁南新时代生物技术有限公司 一种奥利司他的制备方法
CN110031556B (zh) * 2018-11-27 2022-02-15 福建省微生物研究所 毒三素链霉菌发酵产物中lipstatin类代谢产物的快速鉴别方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247547A (en) * 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives
MY116591A (en) * 1996-04-26 2004-02-28 Hoffmann La Roche Process for the production of lipstatin and tetrahydrolipstatin

Also Published As

Publication number Publication date
JP2001039962A (ja) 2001-02-13
EP1028115B1 (en) 2002-11-20
US6156911A (en) 2000-12-05
CN100363354C (zh) 2008-01-23
CA2296996C (en) 2005-11-15
CN1266058A (zh) 2000-09-13
EP1028115A1 (en) 2000-08-16
ATE228118T1 (de) 2002-12-15
KR100336237B1 (ko) 2002-05-09
KR20000076556A (ko) 2000-12-26
ES2185523T3 (es) 2003-05-01
JP3445209B2 (ja) 2003-09-08
CA2296996A1 (en) 2000-07-29
DE60000796D1 (de) 2003-01-02
DE60000796T2 (de) 2003-09-18

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