ES2185523T3 - Purificacion de lipstatina. - Google Patents

Purificacion de lipstatina.

Info

Publication number
ES2185523T3
ES2185523T3 ES00101141T ES00101141T ES2185523T3 ES 2185523 T3 ES2185523 T3 ES 2185523T3 ES 00101141 T ES00101141 T ES 00101141T ES 00101141 T ES00101141 T ES 00101141T ES 2185523 T3 ES2185523 T3 ES 2185523T3
Authority
ES
Spain
Prior art keywords
purification
extraction
lipstatine
lipstatin
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00101141T
Other languages
English (en)
Inventor
Stephan Doswald
Ernst Kupfer
Gerhard Steinbauer
Erich Steinwender
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2185523T3 publication Critical patent/ES2185523T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Un proceso para la purificación de lipstatina de la lipstatina cruda que comprende: a) extracción líquida-líquida de lipstatina de un disolvente no polar seleccionado de un hidrocarburo aromático o alifático en un disolvente polar seleccionado de un ácido carboxílico, un alcohol, un mono-etilenglicol o polietilenglicol O-mono-sustituido, un diol o un disolvente aprótico dipolar seguido por, b) dilución de la fase disolvente polar con agua o modificación de la proporción de la fase y reextracción de lipstatina en un disolvente no polar fresco.
ES00101141T 1999-01-29 2000-01-21 Purificacion de lipstatina. Expired - Lifetime ES2185523T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99101893 1999-01-29

Publications (1)

Publication Number Publication Date
ES2185523T3 true ES2185523T3 (es) 2003-05-01

Family

ID=8237471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00101141T Expired - Lifetime ES2185523T3 (es) 1999-01-29 2000-01-21 Purificacion de lipstatina.

Country Status (10)

Country Link
US (1) US6156911A (es)
EP (1) EP1028115B1 (es)
JP (1) JP3445209B2 (es)
KR (1) KR100336237B1 (es)
CN (1) CN100363354C (es)
AT (1) ATE228118T1 (es)
CA (1) CA2296996C (es)
DE (1) DE60000796T2 (es)
DK (1) DK1028115T3 (es)
ES (1) ES2185523T3 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002362061A1 (en) * 2001-12-04 2003-06-17 Biogal Gyogyszergyar Rt Preparation of orlistat and orlistat crystalline forms
AU2003253254A1 (en) * 2003-07-17 2005-02-04 Biocon Limited Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification
WO2005026140A1 (en) * 2003-09-12 2005-03-24 Ranbaxy Laboratories Limited Process for the preparation of crystalline forms of orlistat
FR2861990B1 (fr) * 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
CN1763021B (zh) * 2005-09-29 2010-08-11 杭州华东医药集团生物工程研究所有限公司 一种提纯奥利司他的方法
EP1803714A1 (en) 2005-12-27 2007-07-04 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing crystalline forms of orlistat
US20080021092A1 (en) * 2006-01-06 2008-01-24 Deepak Murpani Stable pharmaceutical compositions of orlistat
US20100196464A1 (en) * 2007-09-17 2010-08-05 Dr. Reddy's Laboratories Limited Orlistat pharmaceutical formulations
RU2486170C1 (ru) 2009-06-15 2013-06-27 Дайкин Индастриз, Лтд. Способ получения фторсодержащего простого эфира высокой чистоты
CN101948450B (zh) * 2010-10-13 2013-04-24 鲁南制药集团股份有限公司 一种生产制备奥利司他的方法
CN102558103B (zh) * 2010-12-13 2015-01-14 山东新时代药业有限公司 一种分离和纯化奥利司他的方法
CN103030613B (zh) * 2011-09-29 2014-11-12 北大方正集团有限公司 一种利普司他汀的提纯方法
WO2013177492A2 (en) * 2012-05-24 2013-11-28 Northeastern University Novel lipase inhibitors, reporter substrates and uses thereof
CN103420953B (zh) * 2013-07-19 2015-10-21 杭州华东医药集团新药研究院有限公司 一种提纯奥利司他中间体的方法
CN103992296B (zh) * 2014-06-06 2015-08-05 鲁南新时代生物技术有限公司 一种奥利司他的制备方法
CN103992297B (zh) * 2014-06-06 2016-04-13 鲁南制药集团股份有限公司 一种利普司他汀的制备方法
CN110031556B (zh) * 2018-11-27 2022-02-15 福建省微生物研究所 毒三素链霉菌发酵产物中lipstatin类代谢产物的快速鉴别方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247547A (en) * 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives
MY116591A (en) * 1996-04-26 2004-02-28 Hoffmann La Roche Process for the production of lipstatin and tetrahydrolipstatin

Also Published As

Publication number Publication date
DE60000796D1 (de) 2003-01-02
CA2296996C (en) 2005-11-15
KR100336237B1 (ko) 2002-05-09
JP3445209B2 (ja) 2003-09-08
DK1028115T3 (da) 2003-03-17
ATE228118T1 (de) 2002-12-15
JP2001039962A (ja) 2001-02-13
US6156911A (en) 2000-12-05
KR20000076556A (ko) 2000-12-26
CA2296996A1 (en) 2000-07-29
EP1028115B1 (en) 2002-11-20
DE60000796T2 (de) 2003-09-18
CN1266058A (zh) 2000-09-13
EP1028115A1 (en) 2000-08-16
CN100363354C (zh) 2008-01-23

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