BR9701953A - Processo para produção de lipstatina e tetra-hidrolipstatina - Google Patents
Processo para produção de lipstatina e tetra-hidrolipstatinaInfo
- Publication number
- BR9701953A BR9701953A BR9701953A BR9701953A BR9701953A BR 9701953 A BR9701953 A BR 9701953A BR 9701953 A BR9701953 A BR 9701953A BR 9701953 A BR9701953 A BR 9701953A BR 9701953 A BR9701953 A BR 9701953A
- Authority
- BR
- Brazil
- Prior art keywords
- tetrahydrolipstatin
- producing lipstatin
- lipstatin
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Child & Adolescent Psychology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96106598 | 1996-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9701953A true BR9701953A (pt) | 1998-09-15 |
Family
ID=8222717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9701953A BR9701953A (pt) | 1996-04-26 | 1997-04-28 | Processo para produção de lipstatina e tetra-hidrolipstatina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20020110873A1 (pt) |
| EP (1) | EP0803576B1 (pt) |
| JP (1) | JP4094698B2 (pt) |
| CN (1) | CN1128224C (pt) |
| AR (1) | AR006831A1 (pt) |
| AT (1) | ATE229077T1 (pt) |
| BR (1) | BR9701953A (pt) |
| CA (1) | CA2202016C (pt) |
| DE (1) | DE69717530T2 (pt) |
| DK (1) | DK0803576T3 (pt) |
| ES (1) | ES2186818T3 (pt) |
| ID (1) | ID16410A (pt) |
| MY (1) | MY116591A (pt) |
| PT (1) | PT803576E (pt) |
| TR (1) | TR199700289A2 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60000796T2 (de) * | 1999-01-29 | 2003-09-18 | F. Hoffmann-La Roche Ag, Basel | Reinigung von Lipstatin |
| WO2002063976A1 (en) * | 2001-02-09 | 2002-08-22 | Unilever N.V. | Food product comprising soy protein and statins |
| AU2002359601A1 (en) * | 2001-12-04 | 2003-06-17 | Biogal Gyogyszergyar Rt | A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth |
| US6734314B2 (en) * | 2001-12-04 | 2004-05-11 | Biogal Gyogyszergyar Rt. | Preparation of orlistat and orlistat crystalline forms |
| AU2003253254A1 (en) * | 2003-07-17 | 2005-02-04 | Biocon Limited | Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification |
| SK22006A3 (sk) * | 2006-01-03 | 2007-08-02 | Biotika, A. S. | Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom |
| EP1860194A1 (en) * | 2006-05-22 | 2007-11-28 | KRKA, tovarna zdravil, d.d., Novo mesto | Fermentative production of lipstatin |
| WO2009040827A1 (en) * | 2007-09-24 | 2009-04-02 | Biocon Limited | A process for obtaining tetrahydrolipstatin |
| ES2755736T3 (es) * | 2008-03-26 | 2020-04-23 | Biocon Ltd | Proceso de fermentación mejorado para un coeficiente de rendimiento más alto de inhibidor de lipasa respecto al ácido graso consumido |
| CN102268466B (zh) * | 2011-07-23 | 2013-06-12 | 鲁南新时代生物技术有限公司 | 一种发酵生产利普司他汀的方法及其培养基组份 |
| CN103820510B (zh) * | 2014-01-17 | 2016-01-20 | 浙江工业大学 | 一种微生物发酵生产利普司他汀的方法及培养基 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| CH675966A5 (pt) | 1987-02-20 | 1990-11-30 | Firmenich & Cie | |
| CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
-
1996
- 1996-12-20 MY MYPI96005405A patent/MY116591A/en unknown
-
1997
- 1997-03-25 ID IDP970979A patent/ID16410A/id unknown
- 1997-04-07 JP JP08806697A patent/JP4094698B2/ja not_active Expired - Lifetime
- 1997-04-07 CA CA002202016A patent/CA2202016C/en not_active Expired - Lifetime
- 1997-04-10 TR TR97/00289A patent/TR199700289A2/xx unknown
- 1997-04-18 DK DK97106445T patent/DK0803576T3/da active
- 1997-04-18 EP EP97106445A patent/EP0803576B1/en not_active Expired - Lifetime
- 1997-04-18 ES ES97106445T patent/ES2186818T3/es not_active Expired - Lifetime
- 1997-04-18 AT AT97106445T patent/ATE229077T1/de active
- 1997-04-18 PT PT97106445T patent/PT803576E/pt unknown
- 1997-04-18 DE DE69717530T patent/DE69717530T2/de not_active Expired - Lifetime
- 1997-04-24 AR ARP970101680A patent/AR006831A1/es active IP Right Grant
- 1997-04-25 CN CN97109732A patent/CN1128224C/zh not_active Expired - Lifetime
- 1997-04-28 BR BR9701953A patent/BR9701953A/pt not_active Application Discontinuation
-
2002
- 2002-04-17 US US10/124,115 patent/US20020110873A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20020110873A1 (en) | 2002-08-15 |
| JPH1066592A (ja) | 1998-03-10 |
| JP4094698B2 (ja) | 2008-06-04 |
| PT803576E (pt) | 2003-03-31 |
| EP0803576A2 (en) | 1997-10-29 |
| DE69717530T2 (de) | 2003-11-06 |
| MY116591A (en) | 2004-02-28 |
| CA2202016A1 (en) | 1997-10-26 |
| AR006831A1 (es) | 1999-09-29 |
| TR199700289A3 (tr) | 1997-11-21 |
| ES2186818T3 (es) | 2003-05-16 |
| DK0803576T3 (da) | 2003-03-24 |
| EP0803576A3 (en) | 1999-04-21 |
| MX9703057A (es) | 1998-06-30 |
| ID16410A (id) | 1997-10-30 |
| ATE229077T1 (de) | 2002-12-15 |
| TR199700289A2 (en) | 1997-11-21 |
| EP0803576B1 (en) | 2002-12-04 |
| CN1128224C (zh) | 2003-11-19 |
| CN1170761A (zh) | 1998-01-21 |
| DE69717530D1 (de) | 2003-01-16 |
| CA2202016C (en) | 2009-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB34 | Technical and formal requirements: requirement - article 34 of industrial property law | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 37 DA LPI LEI NO9.279 DE 14 DE MAIO DE 1996 CONCLUIMOS O EXAME INDEFERINDO O PRESENTE PEDIDO COM BASE NO ARTIGO 229 DA LEI NO 10.196 DE 14 DE FEVEREIRO DE 2001. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |