ATE229077T1 - Verfahren zur herstellung von lipstatin und tetrahydrolipstatin - Google Patents
Verfahren zur herstellung von lipstatin und tetrahydrolipstatinInfo
- Publication number
- ATE229077T1 ATE229077T1 AT97106445T AT97106445T ATE229077T1 AT E229077 T1 ATE229077 T1 AT E229077T1 AT 97106445 T AT97106445 T AT 97106445T AT 97106445 T AT97106445 T AT 97106445T AT E229077 T1 ATE229077 T1 AT E229077T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydrolipstatin
- producing lipstatin
- lipstatin
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Child & Adolescent Psychology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96106598 | 1996-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE229077T1 true ATE229077T1 (de) | 2002-12-15 |
Family
ID=8222717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97106445T ATE229077T1 (de) | 1996-04-26 | 1997-04-18 | Verfahren zur herstellung von lipstatin und tetrahydrolipstatin |
Country Status (15)
Country | Link |
---|---|
US (1) | US20020110873A1 (de) |
EP (1) | EP0803576B1 (de) |
JP (1) | JP4094698B2 (de) |
CN (1) | CN1128224C (de) |
AR (1) | AR006831A1 (de) |
AT (1) | ATE229077T1 (de) |
BR (1) | BR9701953A (de) |
CA (1) | CA2202016C (de) |
DE (1) | DE69717530T2 (de) |
DK (1) | DK0803576T3 (de) |
ES (1) | ES2186818T3 (de) |
ID (1) | ID16410A (de) |
MY (1) | MY116591A (de) |
PT (1) | PT803576E (de) |
TR (1) | TR199700289A3 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2185523T3 (es) * | 1999-01-29 | 2003-05-01 | Hoffmann La Roche | Purificacion de lipstatina. |
CN100456962C (zh) * | 2001-02-09 | 2009-02-04 | 荷兰联合利华有限公司 | 含大豆蛋白和抑制素的食物制品 |
EP1458882A2 (de) | 2001-12-04 | 2004-09-22 | Biogal Gyogyszergyar Rt. | Fermentationsverfahren für lipstatin und verfahren zur extraktion von lipstatin aus einer fermentationsbrühe |
AU2002362061A1 (en) * | 2001-12-04 | 2003-06-17 | Biogal Gyogyszergyar Rt | Preparation of orlistat and orlistat crystalline forms |
WO2005007639A1 (en) * | 2003-07-17 | 2005-01-27 | Biocon Limited | Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification |
SK22006A3 (sk) * | 2006-01-03 | 2007-08-02 | Biotika, A. S. | Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom |
EP1860194A1 (de) * | 2006-05-22 | 2007-11-28 | KRKA, tovarna zdravil, d.d., Novo mesto | Fermentative Herstellung von Lipstatin |
WO2009040827A1 (en) * | 2007-09-24 | 2009-04-02 | Biocon Limited | A process for obtaining tetrahydrolipstatin |
ES2755736T3 (es) * | 2008-03-26 | 2020-04-23 | Biocon Ltd | Proceso de fermentación mejorado para un coeficiente de rendimiento más alto de inhibidor de lipasa respecto al ácido graso consumido |
CN102268466B (zh) * | 2011-07-23 | 2013-06-12 | 鲁南新时代生物技术有限公司 | 一种发酵生产利普司他汀的方法及其培养基组份 |
CN103820510B (zh) * | 2014-01-17 | 2016-01-20 | 浙江工业大学 | 一种微生物发酵生产利普司他汀的方法及培养基 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
CH675966A5 (de) | 1987-02-20 | 1990-11-30 | Firmenich & Cie | |
CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
-
1996
- 1996-12-20 MY MYPI96005405A patent/MY116591A/en unknown
-
1997
- 1997-03-25 ID IDP970979A patent/ID16410A/id unknown
- 1997-04-07 JP JP08806697A patent/JP4094698B2/ja not_active Expired - Lifetime
- 1997-04-07 CA CA002202016A patent/CA2202016C/en not_active Expired - Lifetime
- 1997-04-10 TR TR97/00289A patent/TR199700289A3/tr unknown
- 1997-04-18 AT AT97106445T patent/ATE229077T1/de active
- 1997-04-18 PT PT97106445T patent/PT803576E/pt unknown
- 1997-04-18 DK DK97106445T patent/DK0803576T3/da active
- 1997-04-18 EP EP97106445A patent/EP0803576B1/de not_active Expired - Lifetime
- 1997-04-18 ES ES97106445T patent/ES2186818T3/es not_active Expired - Lifetime
- 1997-04-18 DE DE69717530T patent/DE69717530T2/de not_active Expired - Lifetime
- 1997-04-24 AR ARP970101680A patent/AR006831A1/es active IP Right Grant
- 1997-04-25 CN CN97109732A patent/CN1128224C/zh not_active Expired - Lifetime
- 1997-04-28 BR BR9701953A patent/BR9701953A/pt not_active Application Discontinuation
-
2002
- 2002-04-17 US US10/124,115 patent/US20020110873A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MY116591A (en) | 2004-02-28 |
DK0803576T3 (da) | 2003-03-24 |
TR199700289A2 (en) | 1997-11-21 |
JP4094698B2 (ja) | 2008-06-04 |
MX9703057A (es) | 1998-06-30 |
AR006831A1 (es) | 1999-09-29 |
CA2202016A1 (en) | 1997-10-26 |
EP0803576A2 (de) | 1997-10-29 |
ES2186818T3 (es) | 2003-05-16 |
US20020110873A1 (en) | 2002-08-15 |
CA2202016C (en) | 2009-12-08 |
TR199700289A3 (tr) | 1997-11-21 |
CN1170761A (zh) | 1998-01-21 |
BR9701953A (pt) | 1998-09-15 |
PT803576E (pt) | 2003-03-31 |
EP0803576A3 (de) | 1999-04-21 |
JPH1066592A (ja) | 1998-03-10 |
ID16410A (id) | 1997-10-30 |
DE69717530D1 (de) | 2003-01-16 |
EP0803576B1 (de) | 2002-12-04 |
CN1128224C (zh) | 2003-11-19 |
DE69717530T2 (de) | 2003-11-06 |
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Legal Events
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---|---|---|---|
UEP | Publication of translation of european patent specification |
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