AR006831A1 - Procedimiento para la produccion de lipstatina y de tetrahidrolipstatina - Google Patents

Procedimiento para la produccion de lipstatina y de tetrahidrolipstatina

Info

Publication number
AR006831A1
AR006831A1 ARP970101680A ARP970101680A AR006831A1 AR 006831 A1 AR006831 A1 AR 006831A1 AR P970101680 A ARP970101680 A AR P970101680A AR P970101680 A ARP970101680 A AR P970101680A AR 006831 A1 AR006831 A1 AR 006831A1
Authority
AR
Argentina
Prior art keywords
lipestatin
linoleic acid
production
leucine
salt
Prior art date
Application number
ARP970101680A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR006831A1 publication Critical patent/AR006831A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Child & Adolescent Psychology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Un procedimiento para la producción por fermentación de la lipestatina, el cual comprende: a)cultivo aeróbico de un microorganismo del orden de losactinomicetos, el cual produce lipestatina, en un medio de cultivo acuoso substancialmenteexent o de grasas y aceites, y que contiene fuentes adecuadasde carbón y nitrógeno y sales inorgánicas, hasta que la fase de crecimiento inicial termina substancialmente y con ello se ha producido la suficiente masade células; b) adición alcaldo, de á cido linoleico, de preferencia junto con ácido caprílico [en donde parte o la totalidad del ácido linoleico y/odel ácido caprílico pueden substituirse por el (los) correspondiente(s) éster(es) y/o sal(es)], y N-formil-L-leucina o de pre ferencia L-leucina,estabilizándose el ácido linoleico o su(s) éster(es) o sal(es) mediante un antioxidante. La lipestatina puede separarse del caldo e hidrogenarse atetrahidrolipestatina.
ARP970101680A 1996-04-26 1997-04-24 Procedimiento para la produccion de lipstatina y de tetrahidrolipstatina AR006831A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96106598 1996-04-26

Publications (1)

Publication Number Publication Date
AR006831A1 true AR006831A1 (es) 1999-09-29

Family

ID=8222717

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101680A AR006831A1 (es) 1996-04-26 1997-04-24 Procedimiento para la produccion de lipstatina y de tetrahidrolipstatina

Country Status (15)

Country Link
US (1) US20020110873A1 (es)
EP (1) EP0803576B1 (es)
JP (1) JP4094698B2 (es)
CN (1) CN1128224C (es)
AR (1) AR006831A1 (es)
AT (1) ATE229077T1 (es)
BR (1) BR9701953A (es)
CA (1) CA2202016C (es)
DE (1) DE69717530T2 (es)
DK (1) DK0803576T3 (es)
ES (1) ES2186818T3 (es)
ID (1) ID16410A (es)
MY (1) MY116591A (es)
PT (1) PT803576E (es)
TR (1) TR199700289A3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1028115T3 (da) * 1999-01-29 2003-03-17 Hoffmann La Roche Oprensning af lipstatin
AU2002235885A1 (en) * 2001-02-09 2002-08-28 Unilever N.V. Process for the preparation of one or more statins by fermentation
WO2003048335A2 (en) * 2001-12-04 2003-06-12 Biogal Gyogyszergyar Rt A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth
US6734314B2 (en) * 2001-12-04 2004-05-11 Biogal Gyogyszergyar Rt. Preparation of orlistat and orlistat crystalline forms
AU2003253254A1 (en) * 2003-07-17 2005-02-04 Biocon Limited Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification
SK22006A3 (sk) * 2006-01-03 2007-08-02 Biotika, A. S. Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom
EP1860194A1 (en) * 2006-05-22 2007-11-28 KRKA, tovarna zdravil, d.d., Novo mesto Fermentative production of lipstatin
WO2009040827A1 (en) * 2007-09-24 2009-04-02 Biocon Limited A process for obtaining tetrahydrolipstatin
JP2011515100A (ja) * 2008-03-26 2011-05-19 バイオコン リミテッド 消費脂肪酸に対して高い収率係数のリパーゼ阻害剤を得る改善された発酵プロセス
CN102268466B (zh) * 2011-07-23 2013-06-12 鲁南新时代生物技术有限公司 一种发酵生产利普司他汀的方法及其培养基组份
CN103820510B (zh) * 2014-01-17 2016-01-20 浙江工业大学 一种微生物发酵生产利普司他汀的方法及培养基

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247547A (en) * 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives
CH675966A5 (es) 1987-02-20 1990-11-30 Firmenich & Cie
CA2098167C (en) * 1992-06-24 2006-12-19 Dorothea Isler Foodstuffs and feedstuffs containing a lipase inhibitor

Also Published As

Publication number Publication date
MX9703057A (es) 1998-06-30
DE69717530D1 (de) 2003-01-16
MY116591A (en) 2004-02-28
CN1170761A (zh) 1998-01-21
BR9701953A (pt) 1998-09-15
DE69717530T2 (de) 2003-11-06
JPH1066592A (ja) 1998-03-10
ATE229077T1 (de) 2002-12-15
EP0803576B1 (en) 2002-12-04
US20020110873A1 (en) 2002-08-15
CA2202016A1 (en) 1997-10-26
EP0803576A2 (en) 1997-10-29
ID16410A (id) 1997-10-30
ES2186818T3 (es) 2003-05-16
EP0803576A3 (en) 1999-04-21
CN1128224C (zh) 2003-11-19
JP4094698B2 (ja) 2008-06-04
PT803576E (pt) 2003-03-31
TR199700289A2 (en) 1997-11-21
CA2202016C (en) 2009-12-08
TR199700289A3 (tr) 1997-11-21
DK0803576T3 (da) 2003-03-24

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