MX9703057A - Procedimiento para la produccion de lipestatina y tetrahidrolipestatina. - Google Patents

Procedimiento para la produccion de lipestatina y tetrahidrolipestatina.

Info

Publication number
MX9703057A
MX9703057A MX9703057A MX9703057A MX9703057A MX 9703057 A MX9703057 A MX 9703057A MX 9703057 A MX9703057 A MX 9703057A MX 9703057 A MX9703057 A MX 9703057A MX 9703057 A MX9703057 A MX 9703057A
Authority
MX
Mexico
Prior art keywords
lipestatyne
linoleic acid
salt
production
acid
Prior art date
Application number
MX9703057A
Other languages
English (en)
Other versions
MXPA97003057A (es
Inventor
Adelbert Bacher
Peter Stohler
Wolfgang Weber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX9703057A publication Critical patent/MX9703057A/es
Publication of MXPA97003057A publication Critical patent/MXPA97003057A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Un procedimiento para la produccion por fermentacion de la lipestatina, el cual procedimiento comprende: a) cultivo aerobico de un microorganismo del orden de los actinomicetos, el cual produce lipestatina, en un medio de cultivo acuoso substancialmente exento de grasas y aceites, y que contiene fuentes adecuadas de carbon y nitrogeno y sales inorgánicas, hasta que la fase de crecimiento inicial termina substancialmente y con ello se ha producido la suficiente masa de células. b) adicion al caldo, de ácido linoleico, de preferencia junto conácido caprílico [en donde parte o la totalidad del ácido linoleico y/o del ácido caprílico pueden substituirse por el(los) correspondiente(s) éster(es) y/o sal (es)], y N-formil-L-leucina o de preferencia L-leucina, estabilizándose el ácido linoleico o su(s) éster(es) o sal(es) mediante un antioxidante. La lipestatina puede separarse del caldo o hidrogenarse o tetrahidrolipestatina.
MXPA/A/1997/003057A 1996-04-26 1997-04-25 Procedimiento para la produccion de lipestatina y tetrahidrolipestatina MXPA97003057A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96106598 1996-04-26
CH96106598.4 1996-04-26

Publications (2)

Publication Number Publication Date
MX9703057A true MX9703057A (es) 1998-06-30
MXPA97003057A MXPA97003057A (es) 1998-10-30

Family

ID=

Also Published As

Publication number Publication date
JP4094698B2 (ja) 2008-06-04
EP0803576B1 (en) 2002-12-04
CA2202016C (en) 2009-12-08
CN1170761A (zh) 1998-01-21
JPH1066592A (ja) 1998-03-10
ES2186818T3 (es) 2003-05-16
ATE229077T1 (de) 2002-12-15
AR006831A1 (es) 1999-09-29
DK0803576T3 (da) 2003-03-24
CN1128224C (zh) 2003-11-19
TR199700289A2 (en) 1997-11-21
TR199700289A3 (tr) 1997-11-21
EP0803576A2 (en) 1997-10-29
US20020110873A1 (en) 2002-08-15
DE69717530D1 (de) 2003-01-16
DE69717530T2 (de) 2003-11-06
BR9701953A (pt) 1998-09-15
MY116591A (en) 2004-02-28
PT803576E (pt) 2003-03-31
CA2202016A1 (en) 1997-10-26
EP0803576A3 (en) 1999-04-21
ID16410A (id) 1997-10-30

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