DE3107601C2 - - Google Patents
Info
- Publication number
- DE3107601C2 DE3107601C2 DE3107601A DE3107601A DE3107601C2 DE 3107601 C2 DE3107601 C2 DE 3107601C2 DE 3107601 A DE3107601 A DE 3107601A DE 3107601 A DE3107601 A DE 3107601A DE 3107601 C2 DE3107601 C2 DE 3107601C2
- Authority
- DE
- Germany
- Prior art keywords
- dihydrocarbostyril
- piperazinyl
- melting point
- group
- crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2880580A JPS56125370A (en) | 1980-03-06 | 1980-03-06 | Carbostyril derivative |
| JP11502280A JPS5738772A (en) | 1980-08-20 | 1980-08-20 | Carbostyril derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3107601A1 DE3107601A1 (de) | 1982-02-04 |
| DE3107601C2 true DE3107601C2 (US07122547-20061017-C00032.png) | 1989-07-20 |
Family
ID=26366952
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3152880A Expired - Fee Related DE3152880C2 (US07122547-20061017-C00032.png) | 1980-03-06 | 1981-02-27 | |
| DE19813107601 Granted DE3107601A1 (de) | 1980-03-06 | 1981-02-27 | Neue carbostyrilderivate, verfahren zu deren herstellung und pharmazeutische verbindungen, welche diese enthalten |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3152880A Expired - Fee Related DE3152880C2 (US07122547-20061017-C00032.png) | 1980-03-06 | 1981-02-27 |
Country Status (21)
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
| FI77852C (fi) * | 1981-02-17 | 1989-05-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat. |
| AU532361B2 (en) * | 1981-09-01 | 1983-09-29 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| US4578381A (en) * | 1982-07-05 | 1986-03-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| CH655110A5 (de) * | 1982-09-03 | 1986-03-27 | Otsuka Pharma Co Ltd | Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten. |
| DE3434271A1 (de) * | 1984-09-19 | 1986-03-20 | Beiersdorf Ag, 2000 Hamburg | Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen |
| DE3509131A1 (de) * | 1985-03-14 | 1986-09-18 | Fa. Carl Zeiss, 7920 Heidenheim | Verfahren zur justierten montage der optischen bauteile eines optischen geraetes |
| US4704390A (en) * | 1986-02-13 | 1987-11-03 | Warner-Lambert Company | Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
| DK167187A (da) | 1986-04-02 | 1987-10-03 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse |
| KR940000785B1 (ko) * | 1986-04-02 | 1994-01-31 | 오오쓰까세이야꾸 가부시끼가이샤 | 카르보스티릴 유도체 및 그의 염의 제조 방법 |
| US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
| ES2053480T3 (es) * | 1986-07-31 | 1994-08-01 | Otsuka Pharma Co Ltd | Un procedimiento para preparar un derivado de carboestirilo. |
| JPH0696555B2 (ja) * | 1986-07-31 | 1994-11-30 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| DE3802030A1 (de) * | 1988-01-25 | 1989-07-27 | Hoechst Ag | Makroporoese, asymmetrische, hydrophile membran aus polyaramid |
| FR2634206B1 (fr) * | 1988-07-12 | 1992-05-15 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique |
| FR2640266B2 (fr) * | 1988-07-12 | 1992-07-10 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
| FR2637591B1 (fr) * | 1988-10-11 | 1992-10-23 | Synthelabo | Derives de quinoleinone, leur preparation et leur application en therapeutique |
| US5006528A (en) * | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| DE69132141T2 (de) * | 1990-05-10 | 2000-09-21 | Pfizer Inc., New York | Neuroprotective indolone und verwandte derivate |
| FR2668149B1 (fr) * | 1990-10-18 | 1994-09-23 | Synthelabo | Le 1-(3,4-dihydro-2-oxo-1h-quinolein-6-yl)-2-[4-(2-phenyl-ethyl)piperidin-1-yl]ethanol, sa preparation et son application en therapeutique. |
| US5147881A (en) * | 1990-11-14 | 1992-09-15 | Pfizer Inc | 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents |
| US5189171A (en) * | 1991-06-21 | 1993-02-23 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
| US5166367A (en) * | 1991-06-21 | 1992-11-24 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
| CA2113568A1 (en) * | 1991-07-17 | 1993-02-04 | Willard Mckowan Welch Jr. | 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents |
| US6255322B1 (en) | 1992-06-19 | 2001-07-03 | Pfizer Inc. | 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents |
| PT650476E (pt) * | 1993-04-07 | 2002-11-29 | Otsuka Pharma Co Ltd | Agente vasodilatador periferico que contem derivados n-acilados de 4-amino-piperidina como ingredientes activos |
| ES2128629T3 (es) * | 1994-10-31 | 1999-05-16 | Merck Patent Gmbh | Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos. |
| ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| DE19812331A1 (de) | 1998-03-20 | 1999-09-23 | Merck Patent Gmbh | Piperidinderivate |
| FR2823749B1 (fr) | 2001-04-20 | 2004-02-20 | Sanofi Synthelabo | Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
| DE10210779A1 (de) * | 2002-03-12 | 2003-10-09 | Merck Patent Gmbh | Cyclische Amide |
| EA007270B1 (ru) * | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н.В. | Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы |
| JP4725945B2 (ja) | 2002-03-13 | 2011-07-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体 |
| PL212089B1 (pl) | 2002-03-13 | 2012-08-31 | Janssen Pharmaceutica Nv | Związki heterocykliczne jako inhibitory deacetylazy histonowej, kompozycja farmaceutyczna je zawierająca, ich zastosowanie, sposób wytwarzania, sposób wykrywania lub identyfikacji HDAC oraz kompozycja |
| OA12789A (en) * | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | Carbonylamino-derivatives as novel inhibitors of histone deacetylase. |
| MY142362A (en) * | 2004-01-29 | 2010-11-30 | Otsuka Pharma Co Ltd | Pharmaceutical composition for promoting angiogenesis |
| DE602005014646D1 (de) * | 2004-07-28 | 2009-07-09 | Janssen Pharmaceutica Nv | Substituierte propenylpiperazinderivate als neue inhibitoren von histondeacetylase |
| RS51189B (sr) * | 2004-07-28 | 2010-10-31 | Janssen Pharmaceutica N.V. | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
| BRPI0512676B8 (pt) * | 2004-07-28 | 2021-05-25 | Janssen Pharmaceutica Nv | derivados de indolil alquil amina substituídos como inibidores de histona desacetilase, composição farmacêutica que os compreende, seus processos de preparação e uso |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| DK1885710T3 (en) | 2005-05-18 | 2015-11-23 | Janssen Pharmaceutica Nv | SUBSTITUTED AMINOPROPENYLPIPERIDINE OR MORPHOLINE DERIVATIVES AS UNKNOWN INHIBITORS OF HISTONDEACETYLASE |
| ATE432272T1 (de) * | 2006-01-19 | 2009-06-15 | Janssen Pharmaceutica Nv | Aminophenylderivate als neue inhibitoren von histondeacetylase |
| JP5137848B2 (ja) * | 2006-01-19 | 2013-02-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体 |
| CA2630717C (en) | 2006-01-19 | 2015-02-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| EP1981875B1 (en) * | 2006-01-19 | 2014-04-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| EP1988077A4 (en) * | 2006-02-23 | 2009-09-02 | Shionogi & Co | NUCLEIC HETEROCYCLIC DERIVATIVES SUBSTITUTED BY CYCLIC GROUPS |
| WO2009034029A2 (de) * | 2007-09-07 | 2009-03-19 | Boehringer Ingelheim International Gmbh | 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten |
| NZ595263A (en) | 2009-02-26 | 2013-06-28 | Compositions, synthesis, and methods of utilizing arylpiperazine derivatives | |
| WO2013169964A1 (en) * | 2012-05-09 | 2013-11-14 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| CN106608875A (zh) | 2015-10-26 | 2017-05-03 | 江苏恩华药业股份有限公司 | 一种稠和杂环类衍生物合成及其应用 |
| CN108031471A (zh) * | 2017-10-27 | 2018-05-15 | 苏州盖德精细材料有限公司 | 一种静电纺丝制备的负载型纳米纤维催化剂及其在3,5-二羟基甲苯制备中的应用 |
| CN108250058B (zh) * | 2018-01-19 | 2022-02-11 | 上海怡立舍生物技术有限公司 | Ppar激动剂及其在治疗老年痴呆及其他疾病中的用途 |
| CN116554127A (zh) * | 2022-01-28 | 2023-08-08 | 成都麻沸散医药科技有限公司 | 哌嗪取代苯酚类衍生物及其用途 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3629266A (en) * | 1969-03-03 | 1971-12-21 | Miles Lab | (phenyl piperidino alkyl)3 4-dihydrocarbostyrils |
| US3910924A (en) * | 1972-04-13 | 1975-10-07 | Otsuka Pharma Co Ltd | 3,4-Dihydrocarbostyril derivatives and a process for preparing the same |
| JPS5239035B2 (US07122547-20061017-C00032.png) * | 1972-12-14 | 1977-10-03 | ||
| US4068076A (en) * | 1972-12-29 | 1978-01-10 | Otsuka Pharmaceutical Co., Ltd. | 5-(1-Hydroxy-2-(heterocyclic amino))ethyl-8-hydroxy-3,4-dihydrocarbostyril derivatives |
| US4026897A (en) * | 1974-01-31 | 1977-05-31 | Otsuka Pharmaceutical Company | 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives |
| US4022784A (en) * | 1974-01-31 | 1977-05-10 | Otsuka Pharmaceutical Company Limited | 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives |
| JPS5310986B2 (US07122547-20061017-C00032.png) * | 1974-02-05 | 1978-04-18 | ||
| JPS5310989B2 (US07122547-20061017-C00032.png) * | 1974-04-25 | 1978-04-18 | ||
| US3994901A (en) * | 1974-06-13 | 1976-11-30 | Otsuka Pharmaceutical Company Limited | 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives |
| US4145542A (en) * | 1974-06-13 | 1979-03-20 | Otsuka Pharmaceutical Co., Ltd. | 5- 1-Hydroxy-2-(heterocyclic-amino)!alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives |
| JPS5112516A (US07122547-20061017-C00032.png) * | 1974-07-21 | 1976-01-31 | Toyoda Automatic Loom Works | |
| JPS5112515A (ja) * | 1974-07-23 | 1976-01-31 | Nikkari Kk | Tankijonpansochiniokeru seidoseigyosochi |
| JPS5116478A (ja) * | 1974-07-30 | 1976-02-09 | Omron Tateisi Electronics Co | Rodenshadanki |
| JPS51125291A (en) * | 1974-12-07 | 1976-11-01 | Otsuka Pharmaceut Co Ltd | A process for preparing novel carbostyryl derivatives |
| JPS51118771A (en) * | 1975-04-09 | 1976-10-18 | Otsuka Pharmaceut Co Ltd | Method for preparing carbostyryl derivatives |
| JPS51118772A (en) * | 1975-04-09 | 1976-10-18 | Otsuka Pharmaceut Co Ltd | Method for preparing carbostyryl derivatives |
| FR2336674A1 (fr) * | 1975-12-24 | 1977-07-22 | Kronenbourg Brasseries | Appareil pour la mesure automatique du temps de resorption de la mousse, en particulier d'une boisson gazeuse, notamment la biere |
| US3994900A (en) * | 1976-01-23 | 1976-11-30 | E. R. Squibb & Sons, Inc. | 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones |
| US4210753A (en) * | 1976-03-17 | 1980-07-01 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds |
| GB1574665A (en) * | 1976-05-08 | 1980-09-10 | Otsuka Pharma Co Ltd | 3,4-dihydrocarbostyril derivatives and process for preparing the same |
| JPS6026797B2 (ja) * | 1976-07-12 | 1985-06-25 | 大塚製薬株式会社 | 新規なカルボスチリル誘導体 |
| JPS609713B2 (ja) * | 1976-10-08 | 1985-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| JPS5416478A (en) * | 1977-07-08 | 1979-02-07 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril herivative |
| JPS54130587A (en) | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| DE2960178D1 (en) * | 1978-06-06 | 1981-04-09 | Hoechst Ag | New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation |
| DE2827566A1 (de) * | 1978-06-23 | 1980-01-10 | Boehringer Mannheim Gmbh | 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung |
| JPS5527158A (en) * | 1978-08-16 | 1980-02-27 | Otsuka Pharmaceut Co Ltd | 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative |
| JPS5583749A (en) * | 1978-12-19 | 1980-06-24 | Yoshitomi Pharmaceut Ind Ltd | Quinolone derivative |
| JPS5589221A (en) * | 1978-12-28 | 1980-07-05 | Otsuka Pharmaceut Co Ltd | Antihistaminic agent |
| JPS5589222A (en) * | 1978-12-28 | 1980-07-05 | Otsuka Pharmaceut Co Ltd | Antihistaminic agent |
| PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
| FI77852C (fi) * | 1981-02-17 | 1989-05-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat. |
| AU532361B2 (en) * | 1981-09-01 | 1983-09-29 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
-
1981
- 1981-02-25 PH PH25264A patent/PH17194A/en unknown
- 1981-02-27 DE DE3152880A patent/DE3152880C2/de not_active Expired - Fee Related
- 1981-02-27 CA CA000371904A patent/CA1155119A/en not_active Expired
- 1981-02-27 DE DE19813107601 patent/DE3107601A1/de active Granted
- 1981-03-02 AU AU67973/81A patent/AU523005B2/en not_active Ceased
- 1981-03-03 FI FI810669A patent/FI76323C/fi not_active IP Right Cessation
- 1981-03-03 AT AT0098481A patent/AT381307B/de not_active IP Right Cessation
- 1981-03-04 SU SU813257001A patent/SU1367857A3/ru active
- 1981-03-04 CH CH1446/81A patent/CH647775A5/de not_active IP Right Cessation
- 1981-03-04 FR FR8104311A patent/FR2477542A1/fr active Granted
- 1981-03-05 IT IT67311/81A patent/IT1144315B/it active
- 1981-03-05 ES ES500137A patent/ES500137A0/es active Granted
- 1981-03-05 NO NO810765A patent/NO159531C/no unknown
- 1981-03-05 DK DK099781A patent/DK155282C/da active
- 1981-03-05 SE SE8101409A patent/SE447255B/sv not_active IP Right Cessation
- 1981-03-05 BE BE0/204016A patent/BE887800A/fr not_active IP Right Cessation
- 1981-03-05 PT PT72622A patent/PT72622B/pt unknown
- 1981-03-06 GB GB8107036A patent/GB2071094B/en not_active Expired
- 1981-03-06 NL NLAANVRAGE8101099,A patent/NL184364C/xx not_active IP Right Cessation
- 1981-03-06 MX MX819337U patent/MX6980E/es unknown
-
1982
- 1982-02-16 ES ES509659A patent/ES509659A0/es active Granted
- 1982-02-16 ES ES509658A patent/ES509658A0/es active Granted
- 1982-03-18 RU SU823406699A patent/RU1779249C/ru active
- 1982-04-07 US US06/366,337 patent/US4460593A/en not_active Expired - Fee Related
- 1982-04-07 US US06/366,336 patent/US4567187A/en not_active Expired - Fee Related
- 1982-04-07 US US06/366,335 patent/US4455422A/en not_active Expired - Fee Related
- 1982-12-29 ES ES518667A patent/ES518667A0/es active Granted
-
1983
- 1983-03-09 US US06/473,641 patent/US4619932A/en not_active Expired - Fee Related
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