DE2943658A1 - Heterocyclische stickstoffderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen - Google Patents

Heterocyclische stickstoffderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen

Info

Publication number
DE2943658A1
DE2943658A1 DE19792943658 DE2943658A DE2943658A1 DE 2943658 A1 DE2943658 A1 DE 2943658A1 DE 19792943658 DE19792943658 DE 19792943658 DE 2943658 A DE2943658 A DE 2943658A DE 2943658 A1 DE2943658 A1 DE 2943658A1
Authority
DE
Germany
Prior art keywords
compound
group
formula
quinoline
pyrano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19792943658
Other languages
German (de)
English (en)
Other versions
DE2943658C2 (es
Inventor
Hugh Cairns
Nigel Chadwick
David Cox
Leicestershire Loughborough
John Louis Suschitzky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of DE2943658A1 publication Critical patent/DE2943658A1/de
Application granted granted Critical
Publication of DE2943658C2 publication Critical patent/DE2943658C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19792943658 1978-10-31 1979-10-29 Heterocyclische stickstoffderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen Granted DE2943658A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7842679 1978-10-31
GB7920760 1979-06-14

Publications (2)

Publication Number Publication Date
DE2943658A1 true DE2943658A1 (de) 1980-05-14
DE2943658C2 DE2943658C2 (es) 1991-08-01

Family

ID=26269406

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792943658 Granted DE2943658A1 (de) 1978-10-31 1979-10-29 Heterocyclische stickstoffderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen

Country Status (32)

Country Link
US (1) US4419352A (es)
AR (1) AR230449A1 (es)
AT (1) AT379811B (es)
AU (1) AU528648B2 (es)
BR (1) BR7907006A (es)
CA (1) CA1142520A (es)
CH (1) CH643264A5 (es)
CS (1) CS231166B2 (es)
CU (1) CU21123A (es)
DD (1) DD146954A5 (es)
DE (1) DE2943658A1 (es)
DK (1) DK458679A (es)
FI (1) FI67702C (es)
FR (1) FR2440371A1 (es)
GR (1) GR73861B (es)
HK (1) HK66185A (es)
HU (1) HU183087B (es)
IE (1) IE49464B1 (es)
IL (1) IL58579A (es)
KE (1) KE3540A (es)
LU (1) LU81841A1 (es)
MA (1) MA18631A1 (es)
MY (1) MY8500439A (es)
NL (1) NL7907916A (es)
NO (1) NO154522C (es)
NZ (1) NZ191956A (es)
PH (1) PH15442A (es)
PL (1) PL130691B1 (es)
PT (1) PT70392A (es)
SE (1) SE451071B (es)
SG (1) SG40885G (es)
SU (1) SU1014476A3 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001681A1 (fr) * 1990-07-25 1992-02-06 Teijin Limited Derive de benzopyrane, sa production, et composition pharmaceutique le contenant

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260306A (en) * 1981-07-24 1993-11-09 Fisons Plc Inhalation pharmaceuticals
GB8402047D0 (en) * 1984-01-26 1984-02-29 Fisons Plc Nitrogen heterocycles
EP0162556B1 (en) * 1984-04-13 1991-11-06 FISONS plc Novels forms and formulations of nedocromil sodium
GB8501015D0 (en) * 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
GB8607159D0 (en) * 1986-03-22 1986-04-30 Smith & Nephew Ass Pharmaceutical composition
NL8701335A (nl) * 1986-06-21 1988-01-18 Sandoz Ag Orale farmaceutische preparaten.
EP0279121B1 (en) * 1986-12-23 1993-09-01 FISONS plc Pharmaceutical compositions comprising an aqueous solution of a pyranoquinoline derivative
USRE38628E1 (en) * 1986-12-23 2004-10-19 Fisons Plc Pharmaceutical compositions
USH672H (en) 1986-12-31 1989-09-05 E. R. Squibb & Sons, Inc. Stable antifungal capsule formulation
US4767612A (en) * 1987-01-23 1988-08-30 Rorer Pharmaceutical Corporation Triamcinolone acetonide for the treatment of allergic rhinitis
GB8704089D0 (en) * 1987-02-21 1987-03-25 Fisons Plc Method of treatment
GB2202145B (en) * 1987-03-17 1991-01-02 Fisons Plc Compositions of nedocromil for dermatological use.
US5648084A (en) * 1990-02-28 1997-07-15 Guttag; Alvin Multiple dosage medicine drop bottle
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
US5453431A (en) * 1993-10-29 1995-09-26 Gilman; Andrew L. Use of hydroxychloroquine for treatment of graft-versus-host disease
ZA966579B (en) * 1995-08-04 1998-02-02 Wakamoto Pharma Co Ltd O/W emulsion composition for eye drops.
US5891472A (en) * 1996-11-19 1999-04-06 Meri Charmyne Russell Treatment of equine laminitis
US5989571A (en) * 1997-07-23 1999-11-23 Millenium Pharmaceutical Technologies, Inc. Contact dermatitis pharmaceutical preparation with anti-histamine and anti-inflammatory
US5885550A (en) * 1998-07-02 1999-03-23 Vallier; Deandra K. Ophthalmic whitening solution
US7101547B1 (en) 1999-01-22 2006-09-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies
AU2001264616A1 (en) * 2000-05-17 2001-11-26 Cor Therapeutics, Inc. Methods for producing amino substituted chromanes and intermediates therefor
US9132116B2 (en) * 2004-08-02 2015-09-15 Willowcroft Pharm Inc. Mast cell stabilizers to prevent or treat laminitis
GB0524808D0 (en) * 2005-12-05 2006-01-11 Novartis Ag Organic compounds
DE102007028095A1 (de) * 2007-06-19 2009-01-15 Bachmann, Vincent Zubereitung zur Behandlung von Hufrehe bei Equiden
FR2924344B1 (fr) * 2007-12-04 2010-04-16 Pf Medicament Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4.
EP2424527B8 (en) * 2009-04-29 2019-07-17 Willowcraft Pharm Inc. Mast cell stabilizers to prevent or treat laminitis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2809720A1 (de) * 1977-03-08 1978-09-14 Takeda Chemical Industries Ltd 1-azaxanthon-3-carbonsaeuren und verfahren zu ihrer herstellung
DE2819215A1 (de) * 1977-05-04 1978-11-16 Fisons Ltd Neue pyranochinolinonderivate, ihre herstellung und verwendung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1504709A (en) * 1974-12-07 1978-03-22 Fisons Ltd N-substituted quinolinone-2-carboxyl. acid der

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2809720A1 (de) * 1977-03-08 1978-09-14 Takeda Chemical Industries Ltd 1-azaxanthon-3-carbonsaeuren und verfahren zu ihrer herstellung
DE2819215A1 (de) * 1977-05-04 1978-11-16 Fisons Ltd Neue pyranochinolinonderivate, ihre herstellung und verwendung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem. 20, 1977, 1337 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001681A1 (fr) * 1990-07-25 1992-02-06 Teijin Limited Derive de benzopyrane, sa production, et composition pharmaceutique le contenant

Also Published As

Publication number Publication date
CS735979A2 (en) 1984-02-13
PL130691B1 (en) 1984-08-31
HK66185A (en) 1985-09-13
DK458679A (da) 1980-05-01
AU5228779A (en) 1980-05-08
FI67702B (fi) 1985-01-31
AU528648B2 (en) 1983-05-05
US4419352A (en) 1983-12-06
LU81841A1 (fr) 1980-05-07
DD146954A5 (de) 1981-03-11
SU1014476A3 (ru) 1983-04-23
NZ191956A (en) 1984-05-31
NL7907916A (nl) 1980-05-02
IL58579A0 (en) 1980-01-31
AR230449A1 (es) 1984-04-30
GR73861B (es) 1984-05-08
SG40885G (en) 1986-05-02
AT379811B (de) 1986-03-10
PL219304A1 (es) 1980-12-01
PT70392A (en) 1979-11-01
NO154522B (no) 1986-06-30
CH643264A5 (fr) 1984-05-30
KE3540A (en) 1985-07-12
FR2440371A1 (fr) 1980-05-30
PH15442A (en) 1983-01-18
DE2943658C2 (es) 1991-08-01
SE7908995L (sv) 1980-05-01
CS231166B2 (en) 1984-10-15
FI67702C (fi) 1985-05-10
NO793469L (no) 1980-05-02
CA1142520A (en) 1983-03-08
HU183087B (en) 1984-04-28
IE792074L (en) 1980-04-30
CU21123A (es) 1982-08-28
IL58579A (en) 1985-12-31
NO154522C (no) 1986-10-08
FI793369A (fi) 1980-05-01
MY8500439A (en) 1985-12-31
ATA701479A (de) 1985-07-15
IE49464B1 (en) 1985-10-16
FR2440371B1 (es) 1983-01-28
MA18631A1 (fr) 1980-07-01
SE451071B (sv) 1987-08-31
BR7907006A (pt) 1980-07-15

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee