DE2830782A1 - Neue substituierte 4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu 1,4-diazepine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen - Google Patents
Neue substituierte 4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu 1,4-diazepine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungenInfo
- Publication number
- DE2830782A1 DE2830782A1 DE19782830782 DE2830782A DE2830782A1 DE 2830782 A1 DE2830782 A1 DE 2830782A1 DE 19782830782 DE19782830782 DE 19782830782 DE 2830782 A DE2830782 A DE 2830782A DE 2830782 A1 DE2830782 A1 DE 2830782A1
- Authority
- DE
- Germany
- Prior art keywords
- thieno
- triazolo
- diazepine
- carbon atoms
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 238000000034 method Methods 0.000 title claims description 6
- 238000004519 manufacturing process Methods 0.000 title description 6
- 239000008194 pharmaceutical composition Substances 0.000 title description 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 32
- -1 R Chemical compound 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 24
- 239000004480 active ingredient Substances 0.000 claims description 17
- 239000000460 chlorine Substances 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 12
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 11
- 229910052794 bromium Inorganic materials 0.000 claims description 11
- 229910052801 chlorine Inorganic materials 0.000 claims description 10
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 9
- 239000001257 hydrogen Substances 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 8
- 150000003254 radicals Chemical class 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 5
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- ONOBXDPYDHTSBQ-UHFFFAOYSA-N 2,3,4,7-tetrahydro-1h-diazepine Chemical compound C1CC=CCNN1 ONOBXDPYDHTSBQ-UHFFFAOYSA-N 0.000 description 2
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- QAQNWCMGKXMUQT-UHFFFAOYSA-N 6,7-dihydro-1h-1,4-diazepine Chemical compound C1CC=NC=CN1 QAQNWCMGKXMUQT-UHFFFAOYSA-N 0.000 description 2
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- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical group COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782830782 DE2830782A1 (de) | 1978-07-13 | 1978-07-13 | Neue substituierte 4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu 1,4-diazepine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
| AT0465279A AT370735B (de) | 1978-07-13 | 1979-07-04 | Verfahren zur herstellung neuer substituierter 4h-s-triazolo(3,4c)-thieno(2,3e)1,4-diazepine |
| GR59552A GR69815B (cs) | 1978-07-13 | 1979-07-09 | |
| SU792783396A SU833160A3 (ru) | 1978-07-13 | 1979-07-09 | Способ получени замещенных 4н-з-триазоло-(3,4-с)тиено(2,3-E)1,4-диАзЕпиНОВ |
| CS794826A CS209929B2 (en) | 1978-07-13 | 1979-07-10 | Method of making the new substituted 4h-s-triazolo/3,4c/-thieno/2,3e/-1,4 diazepins |
| PL1979217029A PL120417B1 (en) | 1978-07-13 | 1979-07-11 | Process for preparing novel substituted 4h-sym-triazolo/3,4-c/thieno/2,3-e/1,4-diazepins4-c tien/2,3-e/1,4-diazepinov |
| BG044296A BG34451A3 (bg) | 1978-07-13 | 1979-07-11 | Метод за получаване на заместени 4н- s- триазоло /3, 4с/ тиено /2, 3е/ 1, 4- диазепини |
| IT49724/79A IT1188845B (it) | 1978-07-13 | 1979-07-11 | 4h-s-triazol(o84)tieno(2,3e)-1,4-diazepine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono |
| DD79214271A DD144777A5 (de) | 1978-07-13 | 1979-07-11 | Verfahren zur herstellung neuer substituierter 4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu-1,4-diazepine |
| IL57776A IL57776A (en) | 1978-07-13 | 1979-07-12 | Substituted 4h-s-triazolo(3,4-c)thieno(2,3-e)1,4-diazepines,their preparation and pharmaceutical compositions containing them |
| NO792319A NO792319L (no) | 1978-07-13 | 1979-07-12 | Analogifremgangsmaate for fremstilling av terapeutisk aktive triazolo-tieno-diazepiner |
| SE7906093A SE7906093L (sv) | 1978-07-13 | 1979-07-12 | Nya substituerade 4h-s-triazolo(3,4c)tieno(2,3e)-1,4-diazepiner, forfaranden for framstellning derav och farmaceutiska kompositioner |
| DK295179A DK295179A (da) | 1978-07-13 | 1979-07-12 | Fremgangsmaade til fremstilling af substituerede 4h-s-triazolo (,4c) thieno 2,3e)-1,4-diazepiner |
| BE0/196277A BE877669A (fr) | 1978-07-13 | 1979-07-12 | Nouvelles 4h-s-triazolo 3,4-c thieno 2,3e 1,4-diazepines, procedes pour leur preparation et medicaments les renfermant |
| JP8754479A JPS5513297A (en) | 1978-07-13 | 1979-07-12 | Diazepin derivative and medical compositiom |
| ES482437A ES482437A1 (es) | 1978-07-13 | 1979-07-12 | Procedimiento para la preparacion de nuevas 4h-s-triazolo-3,4c-tieno,2,3e-1,4-diazepinas sustituidas. |
| PT69910A PT69910A (de) | 1978-07-13 | 1979-07-12 | Neue substituierte 4h-s-triazolo/3,4c/thieno/2,3e/-1,4-diazepine verfahren zu ihrer herstellung und pharmazeutsche zusammensetzungen |
| FI792185A FI792185A7 (fi) | 1978-07-13 | 1979-07-12 | Uudet substituoidut 4H-s-triatsolo/3, 4c/tieno-/2,3e/-1,4- diatsepiinit, niiden valmistusmenetelmät ja farmafarmaseuttiset seokset. |
| LU81494A LU81494A1 (de) | 1978-07-13 | 1979-07-12 | Neue substituierte 4h-s-triazolo(3,4c)thieno(2,3e)-1,4-diaze-pine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
| AU48893/79A AU520063B2 (en) | 1978-07-13 | 1979-07-12 | Substituted 4h-s-triazolo(3,4-c)thieno(2,3-e)1,4-diazepines |
| ES482442A ES482442A1 (es) | 1978-07-13 | 1979-07-12 | Procedimiento para la preparacion de nuevas 4h-s-triazolo-3,4c-tieno-2,3e-1,4-diazepinas sustituidas. |
| HU79BO1796A HU177960B (en) | 1978-07-13 | 1979-07-12 | Process for preparing new disubstituted 4h-s-triazolo/3,4-c/thieno-/2,3-e/-1,4-diazepines |
| RO7998143A RO78104A (ro) | 1978-07-13 | 1979-07-12 | Procedeu pentru prepararea unor 4h-s-triazolo(3,4c)-tieno-(2,3e)1,4-diazepine substituite |
| GB7924357A GB2029408B (en) | 1978-07-13 | 1979-07-12 | 4h-s-traizolo(3,4-c)theino(2,3-e)1,4-diazepines |
| ZA00793509A ZA793509B (en) | 1978-07-13 | 1979-07-12 | Substituted 4h-s-triazolo (3,4-c) thieno-(2,3-e)1,4-diazepines processes for their preparation,and pharmaceutical these compounds |
| FR7918300A FR2430949A1 (fr) | 1978-07-13 | 1979-07-13 | Nouvelles 4h-s-triazolo (3,4c) thieno (2,3e) 1,4-diazepines, procedes pour leur preparation et medicaments les renfermant |
| NL7905483A NL7905483A (nl) | 1978-07-13 | 1979-07-13 | Nieuwe gesubstitueerde 4h-s-triazolo/3,4c/thie- no/2,3e/1,4-diazepinen werkwijze ter bereiding daarvan, alsmede farmaceutische preparaten, die deze verbindin- gen bevatten. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782830782 DE2830782A1 (de) | 1978-07-13 | 1978-07-13 | Neue substituierte 4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu 1,4-diazepine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2830782A1 true DE2830782A1 (de) | 1980-01-24 |
Family
ID=6044278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19782830782 Withdrawn DE2830782A1 (de) | 1978-07-13 | 1978-07-13 | Neue substituierte 4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu 1,4-diazepine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS5513297A (cs) |
| AT (1) | AT370735B (cs) |
| BE (1) | BE877669A (cs) |
| BG (1) | BG34451A3 (cs) |
| CS (1) | CS209929B2 (cs) |
| DD (1) | DD144777A5 (cs) |
| DE (1) | DE2830782A1 (cs) |
| DK (1) | DK295179A (cs) |
| ES (2) | ES482442A1 (cs) |
| FI (1) | FI792185A7 (cs) |
| FR (1) | FR2430949A1 (cs) |
| GB (1) | GB2029408B (cs) |
| GR (1) | GR69815B (cs) |
| HU (1) | HU177960B (cs) |
| IL (1) | IL57776A (cs) |
| IT (1) | IT1188845B (cs) |
| LU (1) | LU81494A1 (cs) |
| NL (1) | NL7905483A (cs) |
| NO (1) | NO792319L (cs) |
| PL (1) | PL120417B1 (cs) |
| PT (1) | PT69910A (cs) |
| RO (1) | RO78104A (cs) |
| SE (1) | SE7906093L (cs) |
| SU (1) | SU833160A3 (cs) |
| ZA (1) | ZA793509B (cs) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696114A (en) * | 1991-11-04 | 1997-12-09 | Korth; Ruth | Treatment and prevention of odema |
| US5852052A (en) * | 1987-10-20 | 1998-12-22 | Ruth Korth | Treatment of lyso paf-mediated mental or neuronal disorders with lyso paf or paf antagonists and procedure for determining their efficacy |
| US5895785A (en) * | 1987-10-20 | 1999-04-20 | Ruth Korth | Treatment and prevention of disorders mediated by LA-paf or endothelial cells |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3709899A (en) * | 1971-04-28 | 1973-01-09 | Upjohn Co | 6-phenyl-4h-s-triazolo(4,3-a)(1,4)benzodiazepines and their production |
| AT338799B (de) * | 1974-03-02 | 1977-09-12 | Boehringer Sohn Ingelheim | Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze |
| FI63033C (fi) * | 1977-07-21 | 1983-04-11 | Boehringer Sohn Ingelheim | Foerfarande foer framstaellning av anxiolytiska tranquilliserande sedativa och/eller neuroleptiska substituerade 1-piperazinyl-4h-s-triazolo(3,4-c)tieno(2,3-e)-1,4-diazepiner |
-
1978
- 1978-07-13 DE DE19782830782 patent/DE2830782A1/de not_active Withdrawn
-
1979
- 1979-07-04 AT AT0465279A patent/AT370735B/de not_active IP Right Cessation
- 1979-07-09 GR GR59552A patent/GR69815B/el unknown
- 1979-07-09 SU SU792783396A patent/SU833160A3/ru active
- 1979-07-10 CS CS794826A patent/CS209929B2/cs unknown
- 1979-07-11 DD DD79214271A patent/DD144777A5/de unknown
- 1979-07-11 IT IT49724/79A patent/IT1188845B/it active
- 1979-07-11 PL PL1979217029A patent/PL120417B1/pl unknown
- 1979-07-11 BG BG044296A patent/BG34451A3/xx unknown
- 1979-07-12 PT PT69910A patent/PT69910A/pt unknown
- 1979-07-12 ES ES482442A patent/ES482442A1/es not_active Expired
- 1979-07-12 ZA ZA00793509A patent/ZA793509B/xx unknown
- 1979-07-12 SE SE7906093A patent/SE7906093L/xx not_active Application Discontinuation
- 1979-07-12 LU LU81494A patent/LU81494A1/de unknown
- 1979-07-12 HU HU79BO1796A patent/HU177960B/hu unknown
- 1979-07-12 IL IL57776A patent/IL57776A/xx unknown
- 1979-07-12 ES ES482437A patent/ES482437A1/es not_active Expired
- 1979-07-12 NO NO792319A patent/NO792319L/no unknown
- 1979-07-12 FI FI792185A patent/FI792185A7/fi not_active Application Discontinuation
- 1979-07-12 BE BE0/196277A patent/BE877669A/fr not_active IP Right Cessation
- 1979-07-12 JP JP8754479A patent/JPS5513297A/ja active Pending
- 1979-07-12 DK DK295179A patent/DK295179A/da not_active Application Discontinuation
- 1979-07-12 RO RO7998143A patent/RO78104A/ro unknown
- 1979-07-12 GB GB7924357A patent/GB2029408B/en not_active Expired
- 1979-07-13 FR FR7918300A patent/FR2430949A1/fr active Granted
- 1979-07-13 NL NL7905483A patent/NL7905483A/nl not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5852052A (en) * | 1987-10-20 | 1998-12-22 | Ruth Korth | Treatment of lyso paf-mediated mental or neuronal disorders with lyso paf or paf antagonists and procedure for determining their efficacy |
| US5895785A (en) * | 1987-10-20 | 1999-04-20 | Ruth Korth | Treatment and prevention of disorders mediated by LA-paf or endothelial cells |
| US5696114A (en) * | 1991-11-04 | 1997-12-09 | Korth; Ruth | Treatment and prevention of odema |
| EP0540767B1 (en) * | 1991-11-04 | 2002-08-07 | Korth, Ruth-Maria, Dr. med | Treatment and prevention of mental diseases mediated by elevated lyso paf levels with paf antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7905483A (nl) | 1980-01-15 |
| IT7949724A0 (it) | 1979-07-11 |
| BG34451A3 (bg) | 1983-09-15 |
| AT370735B (de) | 1983-04-25 |
| CS209929B2 (en) | 1981-12-31 |
| FR2430949B1 (cs) | 1982-11-05 |
| IT1188845B (it) | 1988-01-28 |
| FR2430949A1 (fr) | 1980-02-08 |
| SU833160A3 (ru) | 1981-05-23 |
| DD144777A5 (de) | 1980-11-05 |
| FI792185A7 (fi) | 1981-01-01 |
| GR69815B (cs) | 1982-07-13 |
| SE7906093L (sv) | 1980-01-14 |
| ES482442A1 (es) | 1980-04-01 |
| NO792319L (no) | 1980-01-15 |
| DK295179A (da) | 1980-01-14 |
| RO78104A (ro) | 1982-02-01 |
| IL57776A0 (en) | 1979-11-30 |
| ZA793509B (en) | 1981-03-25 |
| LU81494A1 (de) | 1980-08-08 |
| ATA465279A (de) | 1982-09-15 |
| GB2029408A (en) | 1980-03-19 |
| ES482437A1 (es) | 1980-04-01 |
| PL120417B1 (en) | 1982-02-27 |
| BE877669A (fr) | 1980-01-14 |
| PL217029A1 (cs) | 1980-08-11 |
| PT69910A (de) | 1979-08-01 |
| HU177960B (en) | 1982-02-28 |
| IL57776A (en) | 1983-06-15 |
| JPS5513297A (en) | 1980-01-30 |
| GB2029408B (en) | 1982-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |