DE2560239C2 - 2,3-Dioxopiperazinderivate und Verfahren zu deren Herstellung - Google Patents

2,3-Dioxopiperazinderivate und Verfahren zu deren Herstellung

Info

Publication number
DE2560239C2
DE2560239C2 DE2560239A DE2560239A DE2560239C2 DE 2560239 C2 DE2560239 C2 DE 2560239C2 DE 2560239 A DE2560239 A DE 2560239A DE 2560239 A DE2560239 A DE 2560239A DE 2560239 C2 DE2560239 C2 DE 2560239C2
Authority
DE
Germany
Prior art keywords
acid
dioxo
group
methyl
piperazinocarbonylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2560239A
Other languages
German (de)
English (en)
Inventor
Yutaka Kodama
Miwako Komatsu
Seietsu Kuroda
Kaishu Shinminato Momonoi
Isamu Saikawa
Shuntaro Toyama Takano
Okuta Toyama Takashima
Takashi Yasuda
Chosaku Takaoka Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5066374A external-priority patent/JPS539238B2/ja
Priority claimed from JP5225474A external-priority patent/JPS539239B2/ja
Priority claimed from JP6078774A external-priority patent/JPS539240B2/ja
Priority claimed from JP9199674A external-priority patent/JPS5123284A/ja
Priority claimed from JP10995474A external-priority patent/JPS5139687A/ja
Priority claimed from JP14249974A external-priority patent/JPS5170788A/ja
Priority claimed from JP50037207A external-priority patent/JPS51113890A/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Application granted granted Critical
Publication of DE2560239C2 publication Critical patent/DE2560239C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DE2560239A 1974-05-09 1975-04-30 2,3-Dioxopiperazinderivate und Verfahren zu deren Herstellung Expired DE2560239C2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP5066374A JPS539238B2 (nl) 1974-05-09 1974-05-09
JP5225474A JPS539239B2 (nl) 1974-05-13 1974-05-13
JP6078774A JPS539240B2 (nl) 1974-05-31 1974-05-31
JP9199674A JPS5123284A (en) 1974-08-13 1974-08-13 Shinkina penishirinruino seizoho
JP10995474A JPS5139687A (ja) 1974-09-26 1974-09-26 Shinkinapenishirinruinoseizoho
JP14249974A JPS5170788A (en) 1974-12-13 1974-12-13 Shinkina sefuarosuhorinruino seizoho
JP50037207A JPS51113890A (en) 1975-03-27 1975-03-27 Method for preparing novel cephalosporins

Publications (1)

Publication Number Publication Date
DE2560239C2 true DE2560239C2 (de) 1984-10-11

Family

ID=27564446

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2560239A Expired DE2560239C2 (de) 1974-05-09 1975-04-30 2,3-Dioxopiperazinderivate und Verfahren zu deren Herstellung
DE2519400A Expired DE2519400C3 (de) 1974-05-09 1975-04-30 Penicillinverbindungen, Verfahren zur Herstellung derselben und Mittel mit einem Gehalt derselben

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2519400A Expired DE2519400C3 (de) 1974-05-09 1975-04-30 Penicillinverbindungen, Verfahren zur Herstellung derselben und Mittel mit einem Gehalt derselben

Country Status (18)

Country Link
AR (1) AR209607A1 (nl)
AT (1) AT344906B (nl)
BE (1) BE828692A (nl)
CH (1) CH605995A5 (nl)
CY (1) CY1026A (nl)
DD (1) DD117882A5 (nl)
DE (2) DE2560239C2 (nl)
DK (1) DK151338C (nl)
FI (1) FI63760C (nl)
FR (2) FR2269937B1 (nl)
GB (2) GB1508064A (nl)
HK (1) HK26279A (nl)
HU (1) HU169633B (nl)
IL (2) IL47168A (nl)
KE (1) KE2923A (nl)
NL (1) NL162386C (nl)
PH (5) PH21545A (nl)
SE (2) SE431457B (nl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2528079A1 (de) * 1975-06-24 1977-01-20 Bayer Ag Penicilline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH624958A5 (en) * 1975-06-24 1981-08-31 Bayer Ag Process for the preparation of beta-lactam compounds
FR2338046A2 (fr) * 1976-01-19 1977-08-12 Toyama Chemical Co Ltd Nouvelles cephalosporines, leur procede de preparation et leur application en therapeutique
JPS6026800B2 (ja) * 1976-01-22 1985-06-25 富山化学工業株式会社 新規な７α−メトキシセフアロスポリン類およびその製造法
JPS52106883A (en) * 1976-02-13 1977-09-07 Toyama Chem Co Ltd Novel penicillins and cephalosporins
JPS5331690A (en) * 1976-09-01 1978-03-25 Shionogi & Co Ltd Oxadithiacephalosporins
DE2857696C2 (de) * 1977-07-23 1984-08-30 Toyama Chemical Co. Ltd., Tokio / Tokyo Cephalosporine
DE2810083A1 (de) * 1978-03-08 1979-09-20 Bayer Ag Beta-lactam-verbindungen
DE2813771A1 (de) * 1978-03-30 1979-10-11 Bayer Ag Beta-lactam-verbindungen
DE2817228A1 (de) * 1978-04-20 1979-10-31 Bayer Ag Verfahren zur herstellung halbsynthetischer beta-lactamantibiotika
EP0015240A1 (de) * 1979-02-16 1980-09-03 Ciba-Geigy Ag Azacyclyl (thio) ureidoacetyl-Verbindungen und Verfahren zu ihrer Herstellung
CA1209477A (en) * 1981-03-26 1986-08-12 Bruce E. Haeger Composition of matter comprising a lyophilized preparation of a penicillin derivative
CA1200239A (en) * 1981-03-30 1986-02-04 Donald C. Boop Process for preparing 6-¬d-(-)-alpha-(4-c1-c4 alkyl- 2,3-dioxo-1-piperazinocarbonyl-amino)- phenylacetamido|penicillanic acid
JPS57118587A (en) * 1981-11-26 1982-07-23 Toyama Chem Co Ltd Novel penicillin
BG46664A1 (en) * 1985-08-16 1990-02-15 Druzhestven N Izsledovatelski Method for preparing of 6- /d (-)- alpha- (4- ethyl- 2, 3- dioxo- 1- piperazine carbonylamino)- phenylacetamido/- penicillanic acid
DE3619562A1 (de) * 1986-06-11 1987-12-17 Basf Ag Verfahren zur herstellung von 2,3-dioxo-4-oxicarbonylpiperazinderivaten, neue 2,3-dioxo-4-oxicarbonylpiperazinderivate und deren verwendung
US5859012A (en) * 1996-04-03 1999-01-12 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
ES2335092T3 (es) 2001-08-24 2010-03-22 Yale University Compuestos de piperazinona como agentes antitumorales y anticancer.
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
JP2005522436A (ja) 2002-02-08 2005-07-28 グラクソ　グループ　リミテッド ピペリジルカルボキシアミド誘導体またはそのタキキニン介在疾患の治療における使用
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
CN101611040A (zh) * 2007-01-31 2009-12-23 富山化学工业株式会社 哌拉西林钠的新颖结晶
RS55365B1 (sr) 2008-10-31 2017-03-31 Shionogi & Co Cefalosporin sa kateholskom grupom
WO2011125966A1 (ja) 2010-04-05 2011-10-13 塩野義製薬株式会社 擬似カテコール基を有するセフェム化合物
KR20130018845A (ko) 2010-04-05 2013-02-25 시오노기세야쿠 가부시키가이샤 카테콜기를 갖는 세펨 화합물
US9085589B2 (en) 2010-04-28 2015-07-21 Shionogi & Co., Ltd. Cephem derivative
CA2833121A1 (en) 2011-04-28 2012-11-01 Shionogi & Co., Ltd. Novel cephem compound having catechol or pseudo-catechol structure
US9242999B2 (en) 2011-06-27 2016-01-26 Shionogi & Co., Ltd. Cephem compound having pyridinium group
CN110746445B (zh) * 2019-10-16 2021-03-16 深圳海关食品检验检疫技术中心 一种头孢哌酮氘代内标物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1770620A1 (de) * 1968-06-12 1971-11-11 Bayer Ag Neue Penicilline
DE2104580C3 (de) * 1971-02-01 1981-04-02 Bayer Ag, 5090 Leverkusen Acylureidopenicilline
DE2025415C3 (de) * 1970-05-25 1981-01-22 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von cyclischen Acylureido-Penicillinen
US3741962A (en) 1971-05-21 1973-06-26 Squibb & Sons Inc Alpha-thioureidocephalosporanic acid compounds
BE790440A (nl) * 1971-10-23 1973-04-24 Bayer Ag
BE794886A (fr) * 1972-02-22 1973-08-02 Pfizer Acides 6-(alpha-(omega-guanidinoalcanoylamino)acylamino)-penicillaniques
CH570407A5 (nl) * 1972-03-29 1975-12-15 Ciba Geigy Ag
AR204162A1 (es) * 1972-05-08 1975-11-28 Yamanouchi Pharma Co Ltd Proceso para la preparacion de derivados de ampicilina
AR208171A1 (es) 1972-09-29 1976-12-09 Ciba Geigy Ag Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT *

Also Published As

Publication number Publication date
AU8043175A (en) 1976-10-28
PH21987A (en) 1988-05-02
DE2519400C3 (de) 1982-02-11
FI751340A (nl) 1975-11-10
GB1508064A (en) 1978-04-19
DD117882A5 (nl) 1976-02-05
HU169633B (nl) 1976-12-28
IL53485A0 (en) 1978-01-31
SE7505392L (sv) 1975-12-23
IL47168A0 (en) 1975-06-25
NL162386B (nl) 1979-12-17
PH21545A (en) 1987-12-11
FR2269937A1 (nl) 1975-12-05
CY1026A (en) 1980-08-01
FR2320295A1 (fr) 1977-03-04
DK201975A (da) 1975-11-10
KE2923A (en) 1979-04-06
PH20534A (en) 1987-02-09
NL162386C (nl) 1980-05-16
DE2519400A1 (de) 1976-03-04
FR2269937B1 (nl) 1979-06-15
FI63760B (fi) 1983-04-29
FR2320295B1 (nl) 1980-11-07
DK151338C (da) 1988-07-18
SE431457B (sv) 1984-02-06
BE828692A (fr) 1975-11-03
CH605995A5 (nl) 1978-10-13
SE7808204L (sv) 1978-07-27
AR209607A1 (es) 1977-05-13
SE435062B (sv) 1984-09-03
DK151338B (da) 1987-11-23
AT344906B (de) 1978-08-25
GB1508062A (en) 1978-04-19
HK26279A (en) 1979-05-04
FI63760C (fi) 1983-08-10
PH22346A (en) 1988-08-12
DE2519400B2 (de) 1981-05-21
ATA828976A (de) 1977-12-15
IL47168A (en) 1979-07-25
NL7505375A (nl) 1975-11-11
PH22336A (en) 1988-08-12

Similar Documents

Publication Publication Date Title
DE2560239C2 (de) 2,3-Dioxopiperazinderivate und Verfahren zu deren Herstellung
CH628058A5 (de) Verfahren zur herstellung von cephemverbindungen.
CH633558A5 (de) Verfahren zur herstellung neuer cephalosporinderivate.
DE2538804C2 (de) Cephalosporinderivate, Verfahren zu ihrer Herstellung und sie enthaltende Mittel
DE2216146A1 (de) Verfahren zur Herstellung von Cephalosporinderivaten
CH644129A5 (de) 3-unsubstituierte-3-cephemverbindungen, sowie verfahren zu ihrer herstellung.
DE2324272A1 (de) 3-methylencephalosporine
DE2824575A1 (de) 1,3-dithietan-2-carbonsaeuren sowie verfahren zu ihrer herstellung
DE2857696C2 (de) Cephalosporine
DE2804040C3 (de) Verfahren zur Herstellung von Cephemverbindungen
CH622799A5 (nl)
DE2534926A1 (de) Sauerstoffanaloge von cephalosporinen
CH623330A5 (en) Process for the preparation of cephalosporin derivatives
DE2651509C2 (de) Verfahren zur Herstellung von 3-Cephemverbindungen
DE2633005A1 (de) Cephem- und penamverbindungen und verfahren zu ihrer herstellung
DE2559932C2 (de) Cephalosporine, Verfahren zur Herstellung derselben und Mittel mit einem Gehalt derselben
DE2451492A1 (de) 2-oxo-1-pyridinyl-penicillin- und -cephalosporin-derivate
CH666037A5 (de) Verfahren zur herstellung von cephalosporin-syn-isomeren.
CH631988A5 (de) Verfahren zur herstellung von 3-(alkylsulfonamidoalkyltetrazolylthiomethyl)-cephalosporin-derivaten.
CH621351A5 (nl)
DE2702552A1 (de) 7alpha-methoxy-cephalosporine und verfahren zur herstellung derselben
AT337357B (de) Verfahren zur herstellung von neuen penamderivaten
CH638781A5 (de) Verfahren zur herstellung von beta-lactamen.
DE2722666C2 (de) 7-Acylamino-3-pyrazinylthiomethyl- 3-cephem-4-carbonsäure-Verbindungen und ihre Verwendung/Bekämpfung bakterieller Infektionen
AT368149B (de) Verfahren zur herstellung von neuen glyoxylsaeureverbindungen

Legal Events

Date Code Title Description
OI Miscellaneous see part 1
OI Miscellaneous see part 1
OD Request for examination
AC Divided out of

Ref country code: DE

Ref document number: 2519400

Format of ref document f/p: P

D2 Grant after examination
8364 No opposition during term of opposition