GB1508062A - Penicillins and cephalosporins and process for producing the same - Google Patents
Penicillins and cephalosporins and process for producing the sameInfo
- Publication number
- GB1508062A GB1508062A GB17557/75A GB1755775A GB1508062A GB 1508062 A GB1508062 A GB 1508062A GB 17557/75 A GB17557/75 A GB 17557/75A GB 1755775 A GB1755775 A GB 1755775A GB 1508062 A GB1508062 A GB 1508062A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- alkoxycarbonyl
- alkoxy
- cycloalkoxycarbonyl
- acyloxyalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1508062 Penicillin and cephalosporin derivatives TOYAMA CHEMICAL CO Ltd 28 April 1975 [9 May 1974 13 May 1974 31 May 1974 24 July 1974 7 Aug 1974 13 Aug 1974 26 Sept 1974 12 Oct 1974 28 Oct 1974 6 Dec 1974 13 Dec 1974 17 Feb 1975 26 March 1975 27 March 1975] 17557/75 Heading C2C Novel compounds I (R is an amino acid residue; R<SP>1</SP> is H, an ester forming group, a cation or a silicon-, phosphorus-, or tin-containing group; n is 1 or 2; n X's which may be the same as or different from each other represent individually O or S and are linked in any combination at the 2-, 3- and 5-positions of the piperazine ring; m is 4-n; each pair of R<SP>2</SP> and R<SP>3</SP> is linked to the same carbon atom and m pairs of R<SP>2</SP> and R<SP>3</SP> represent individually H, halo, COOH, or an unsubstituted or substituted alkyl, cycloalkyl, aryl, acyl, aralkyl, alkoxycarbonyl-alkyl, acyloxyalkyl, alkoxy, alkoxycarbonyl, cycloalkoxycarbonyl, aralkoxycarbinyl, aryloxycarbonyl, amino or carbamoyl; or R<SP>2</SP> and R<SP>3</SP> together with the attached carbon atom form a cycloalkane ring; A is H, OH, NO 2 , CN or an optionally substituted alkyl, alkenyl, alkynyl, alkadienyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, aryl, acyl, aralkyl, acyloxyalkyl, alkoxy, cycloalkoxy, aryloxy, alkoxycarbonyl, cycloalkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulphonyl, cycloalkylsulphuryl, arylsulphonyl, carbamoyl, thiocarbamoyl, acylcarbamoyl, acylthiocarbamoyl, alkylsulphonylcarbamoyl, arylsulphonylcarbamoyl, alkylsulphonylthiocarbamoyl, arylsulphonylthiocarbamoyl, sulphamoyl, alkoxycarbonylthioalkyl, alkoxythiocarbonylthioalkyl, amino or heterocyclyl; Y is O or S; -Z- is -C(CH 3 ) 2 - or -CH 2 C(CH 2 R<SP>4</SP>)= and R<SP>4</SP> is H, OH, CN, N 3 , quaternary ammonium or an optionally substituted alkoxy, aryloxy, aralkoxy, acyloxy, carbamoyloxy, guanidino, amino, alkylthio, arylthio, aralkylthio, acylthio, thiocarbamoylthio, alkoxythiocarbonylthio, aryloxythiocarbonylthio, cycloalkoxythiocarbonylthio, amidinothio or heterocyclyl-thio) are prepared by conventional acylation of a compound II or IV followed where necessary by conventional chemical modification of the side chain in the cephalosporin nucleus. Pharmaceutical compositions useful as antibacterial agents comprise a compound I together with a suitable diluent and/or carrier.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CY102875A CY1028A (en) | 1974-05-09 | 1975-04-28 | |
| CY102775A CY1027A (en) | 1974-05-09 | 1975-04-28 | 2,3-dioxopiperazine derivatives |
| CY102976A CY1029A (en) | 1974-05-09 | 1976-01-19 | Cephalosporins and process for producing the same |
| KE292679A KE2926A (en) | 1975-04-28 | 1979-03-01 | Novel cephalosporins and process for producing the same |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5066374A JPS539238B2 (en) | 1974-05-09 | 1974-05-09 | |
| JP5225474A JPS539239B2 (en) | 1974-05-13 | 1974-05-13 | |
| JP6078774A JPS539240B2 (en) | 1974-05-31 | 1974-05-31 | |
| JP9199674A JPS5123284A (en) | 1974-08-13 | 1974-08-13 | Shinkina penishirinruino seizoho |
| JP10995474A JPS5139687A (en) | 1974-09-26 | 1974-09-26 | SHINKINAPENISHIRINRUINOSEIZOHO |
| JP14249974A JPS5170788A (en) | 1974-12-13 | 1974-12-13 | Shinkina sefuarosuhorinruino seizoho |
| JP50037207A JPS51113890A (en) | 1975-03-27 | 1975-03-27 | Method for preparing novel cephalosporins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1508062A true GB1508062A (en) | 1978-04-19 |
Family
ID=27564446
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15360/77A Expired GB1508064A (en) | 1974-05-09 | 1975-04-28 | Amino acid derivatives |
| GB17557/75A Expired GB1508062A (en) | 1974-05-09 | 1975-04-28 | Penicillins and cephalosporins and process for producing the same |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15360/77A Expired GB1508064A (en) | 1974-05-09 | 1975-04-28 | Amino acid derivatives |
Country Status (18)
| Country | Link |
|---|---|
| AR (1) | AR209607A1 (en) |
| AT (1) | AT344906B (en) |
| BE (1) | BE828692A (en) |
| CH (1) | CH605995A5 (en) |
| CY (1) | CY1026A (en) |
| DD (1) | DD117882A5 (en) |
| DE (2) | DE2519400C3 (en) |
| DK (1) | DK151338C (en) |
| FI (1) | FI63760C (en) |
| FR (2) | FR2269937B1 (en) |
| GB (2) | GB1508064A (en) |
| HK (1) | HK26279A (en) |
| HU (1) | HU169633B (en) |
| IL (2) | IL47168A (en) |
| KE (1) | KE2923A (en) |
| NL (1) | NL162386C (en) |
| PH (5) | PH21545A (en) |
| SE (2) | SE431457B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642240B2 (en) | 1999-10-07 | 2003-11-04 | Smithkline Beecham Corporation | Treating emesis in a mammal |
| US7060702B2 (en) | 2000-10-17 | 2006-06-13 | Smithkline Beecham Corporation | Chemical compounds |
| US7189713B2 (en) | 2002-02-08 | 2007-03-13 | Glaxo Group Limited | Piperidine derivatives |
| US7276509B2 (en) | 2002-02-08 | 2007-10-02 | Glaxo Group Limited | Piperidine derivatives and their use as antagonists of tachykinins |
| USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
| US7482365B2 (en) | 2002-02-08 | 2009-01-27 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases |
| EP2128162A1 (en) * | 2007-01-31 | 2009-12-02 | Toyama Chemical Co., Ltd. | Novel crystal of piperacillin sodium |
| CN110746445A (en) * | 2019-10-16 | 2020-02-04 | 深圳海关食品检验检疫技术中心 | Preparation method of cefoperazone deuterated internal standard substance |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH624958A5 (en) * | 1975-06-24 | 1981-08-31 | Bayer Ag | Process for the preparation of beta-lactam compounds |
| DE2528079A1 (en) * | 1975-06-24 | 1977-01-20 | Bayer Ag | PENICILLIN, THE METHOD FOR MANUFACTURING IT AND THEIR USE AS A MEDICINAL PRODUCT |
| FR2338046A2 (en) * | 1976-01-19 | 1977-08-12 | Toyama Chemical Co Ltd | Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids |
| JPS6026800B2 (en) * | 1976-01-22 | 1985-06-25 | 富山化学工業株式会社 | Novel 7α-methoxycephalosporins and their production method |
| JPS52106883A (en) * | 1976-02-13 | 1977-09-07 | Toyama Chem Co Ltd | Novel penicillins and cephalosporins |
| JPS5331690A (en) * | 1976-09-01 | 1978-03-25 | Shionogi & Co Ltd | Oxadithiacephalosporins |
| DE2831568C2 (en) * | 1977-07-23 | 1985-01-10 | Toyama Chemical Co. Ltd., Tokio / Tokyo | 7 α-Methoxycephalosporins and methods for making the same |
| DE2810083A1 (en) * | 1978-03-08 | 1979-09-20 | Bayer Ag | BETA-LACTAM COMPOUNDS |
| DE2813771A1 (en) * | 1978-03-30 | 1979-10-11 | Bayer Ag | BETA-LACTAM COMPOUNDS |
| DE2817228A1 (en) * | 1978-04-20 | 1979-10-31 | Bayer Ag | PROCESS FOR MANUFACTURING SEMI-SYNTHETIC BETA-LACTAMANTIBIOTICS |
| EP0015240A1 (en) * | 1979-02-16 | 1980-09-03 | Ciba-Geigy Ag | Azacyclyl (thio) ureidoacetyl compounds and their preparation |
| CA1209477A (en) * | 1981-03-26 | 1986-08-12 | Bruce E. Haeger | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
| CA1200239A (en) * | 1981-03-30 | 1986-02-04 | Donald C. Boop | Process for preparing 6-¬d-(-)-alpha-(4-c1-c4 alkyl- 2,3-dioxo-1-piperazinocarbonyl-amino)- phenylacetamido|penicillanic acid |
| JPS57118587A (en) * | 1981-11-26 | 1982-07-23 | Toyama Chem Co Ltd | Novel penicillin |
| BG46664A1 (en) * | 1985-08-16 | 1990-02-15 | Druzhestven N Izsledovatelski | Method for preparing of 6- /d (-)- alpha- (4- ethyl- 2, 3- dioxo- 1- piperazine carbonylamino)- phenylacetamido/- penicillanic acid |
| DE3619562A1 (en) * | 1986-06-11 | 1987-12-17 | Basf Ag | METHOD FOR PRODUCING 2,3-DIOXO-4-OXICARBONYLPIPERAZINE DERIVATIVES, NEW 2,3-DIOXO-4-OXICARBONYLPIPERAZINE DERIVATIVES AND THE USE THEREOF |
| US5859012A (en) * | 1996-04-03 | 1999-01-12 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU2002332640B2 (en) | 2001-08-24 | 2007-11-08 | University Of South Florida | Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment |
| AU2009310959B2 (en) | 2008-10-31 | 2015-05-07 | Shionogi & Co., Ltd. | Cephalosporin having catechol group |
| MX2012011521A (en) | 2010-04-05 | 2013-03-08 | Shionogi & Co | Cephem compound having catechol group. |
| US8883773B2 (en) | 2010-04-05 | 2014-11-11 | Shionogi & Co., Ltd. | Cephem compound having pseudo-catechol group |
| WO2011136268A1 (en) | 2010-04-28 | 2011-11-03 | 塩野義製薬株式会社 | Novel cephem derivative |
| CA2833121A1 (en) | 2011-04-28 | 2012-11-01 | Shionogi & Co., Ltd. | Novel cephem compound having catechol or pseudo-catechol structure |
| WO2013002215A1 (en) | 2011-06-27 | 2013-01-03 | 塩野義製薬株式会社 | Cephem compound having pyridinium group |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1770620A1 (en) * | 1968-06-12 | 1971-11-11 | Bayer Ag | New penicillins |
| DE2104580C3 (en) * | 1971-02-01 | 1981-04-02 | Bayer Ag, 5090 Leverkusen | Acylureidopenicillins |
| DE2025415C3 (en) * | 1970-05-25 | 1981-01-22 | Bayer Ag, 5090 Leverkusen | Process for the preparation of cyclic acylureido penicillins |
| US3741962A (en) | 1971-05-21 | 1973-06-26 | Squibb & Sons Inc | Alpha-thioureidocephalosporanic acid compounds |
| BE790440A (en) * | 1971-10-23 | 1973-04-24 | Bayer Ag | |
| BE794886A (en) * | 1972-02-22 | 1973-08-02 | Pfizer | 6- (ALPHA- (OMEGA-GUANIDINOALCANOYLAMINO) ACYLAMINO) -PENICILLANIC ACIDS |
| CH570407A5 (en) * | 1972-03-29 | 1975-12-15 | Ciba Geigy Ag | |
| AR204162A1 (en) * | 1972-05-08 | 1975-11-28 | Yamanouchi Pharma Co Ltd | PROCESS FOR THE PREPARATION OF AMPICILLIN DERIVATIVES |
| AR208171A1 (en) | 1972-09-29 | 1976-12-09 | Ciba Geigy Ag | PROCEDURE FOR OBTAINING NEW DERIVATIVES OF CEF-3-EM-4-CARBOXYL ACID |
-
1975
- 1975-04-24 IL IL47168A patent/IL47168A/en unknown
- 1975-04-28 GB GB15360/77A patent/GB1508064A/en not_active Expired
- 1975-04-28 GB GB17557/75A patent/GB1508062A/en not_active Expired
- 1975-04-28 CY CY1026A patent/CY1026A/en unknown
- 1975-04-30 DE DE2519400A patent/DE2519400C3/en not_active Expired
- 1975-04-30 DE DE2560239A patent/DE2560239C2/en not_active Expired
- 1975-05-02 BE BE156035A patent/BE828692A/en not_active IP Right Cessation
- 1975-05-05 PH PH17137A patent/PH21545A/en unknown
- 1975-05-06 CH CH584775A patent/CH605995A5/xx not_active IP Right Cessation
- 1975-05-06 AR AR258658A patent/AR209607A1/en active
- 1975-05-06 FR FR7514159A patent/FR2269937B1/fr not_active Expired
- 1975-05-07 NL NL7505375.A patent/NL162386C/en not_active IP Right Cessation
- 1975-05-07 FI FI751340A patent/FI63760C/en not_active IP Right Cessation
- 1975-05-07 DK DK201975A patent/DK151338C/en not_active IP Right Cessation
- 1975-05-08 DD DD185922A patent/DD117882A5/xx unknown
- 1975-05-08 HU HUTO1002A patent/HU169633B/hu unknown
- 1975-05-09 SE SE7505392A patent/SE431457B/en not_active IP Right Cessation
-
1976
- 1976-02-10 PH PH18076A patent/PH20534A/en unknown
- 1976-10-22 FR FR7631895A patent/FR2320295A1/en active Granted
- 1976-11-08 AT AT828976A patent/AT344906B/en not_active IP Right Cessation
- 1976-11-15 PH PH19128A patent/PH22346A/en unknown
- 1976-11-15 PH PH19129A patent/PH22336A/en unknown
-
1977
- 1977-05-25 PH PH19814A patent/PH21987A/en unknown
- 1977-11-29 IL IL53485A patent/IL53485A0/en not_active IP Right Cessation
-
1978
- 1978-07-27 SE SE7808204A patent/SE435062B/en not_active IP Right Cessation
-
1979
- 1979-03-01 KE KE2923A patent/KE2923A/en unknown
- 1979-04-26 HK HK262/79A patent/HK26279A/en unknown
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
| US6951861B1 (en) | 1999-10-07 | 2005-10-04 | Smithkline Beechan Corporation | Chemical compounds |
| US7625904B2 (en) | 1999-10-07 | 2009-12-01 | Smithkline Beecham Corporation | Methods for the treatment of sleep disorders |
| US7071196B2 (en) | 1999-10-07 | 2006-07-04 | Smithkline Beecham Croporation | Chemical compounds |
| US7345041B2 (en) | 1999-10-07 | 2008-03-18 | Smithkline Beecham Corporation | Chemical compounds |
| US6642240B2 (en) | 1999-10-07 | 2003-11-04 | Smithkline Beecham Corporation | Treating emesis in a mammal |
| US7294630B2 (en) | 2000-10-17 | 2007-11-13 | Smithkline Beecham Corporation | Piperazinyl piperidine tachykinin antagonists |
| US7119092B2 (en) | 2000-10-17 | 2006-10-10 | Smithkline Beecham Corporation | Chemical compounds |
| US7060702B2 (en) | 2000-10-17 | 2006-06-13 | Smithkline Beecham Corporation | Chemical compounds |
| US7648990B2 (en) | 2000-10-17 | 2010-01-19 | Glaxosmithkline Llc | Chemical compounds |
| US7276509B2 (en) | 2002-02-08 | 2007-10-02 | Glaxo Group Limited | Piperidine derivatives and their use as antagonists of tachykinins |
| US7189713B2 (en) | 2002-02-08 | 2007-03-13 | Glaxo Group Limited | Piperidine derivatives |
| US7482365B2 (en) | 2002-02-08 | 2009-01-27 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases |
| US7652012B2 (en) | 2002-02-08 | 2010-01-26 | Glaxo Group Limited | 2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof |
| EP2128162A1 (en) * | 2007-01-31 | 2009-12-02 | Toyama Chemical Co., Ltd. | Novel crystal of piperacillin sodium |
| EP2128162A4 (en) * | 2007-01-31 | 2011-05-25 | Toyama Chemical Co Ltd | Novel crystal of piperacillin sodium |
| CN110746445A (en) * | 2019-10-16 | 2020-02-04 | 深圳海关食品检验检疫技术中心 | Preparation method of cefoperazone deuterated internal standard substance |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19950427 |