FR2338046A2 - Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids - Google Patents

Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids

Info

Publication number
FR2338046A2
FR2338046A2 FR7601283A FR7601283A FR2338046A2 FR 2338046 A2 FR2338046 A2 FR 2338046A2 FR 7601283 A FR7601283 A FR 7601283A FR 7601283 A FR7601283 A FR 7601283A FR 2338046 A2 FR2338046 A2 FR 2338046A2
Authority
FR
France
Prior art keywords
lactamase
cpd
beta
broad
4pethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7601283A
Other languages
French (fr)
Other versions
FR2338046B2 (en
Inventor
Isanu Saikawa
Shuntaro Takano
Chosaku Yoshida
Okuta Takashima
Kaishu Momonoi
Seietsu Kuroda
Miwako Kamatsu
Takashi Yasuda
Yutaka Kodama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to FR7601283A priority Critical patent/FR2338046A2/en
Publication of FR2338046A2 publication Critical patent/FR2338046A2/en
Application granted granted Critical
Publication of FR2338046B2 publication Critical patent/FR2338046B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Abstract

Cephalosporins of formula (I): (where R1 = H, a cation or a blocking group and R2 = acetoxy (cpd. C) carbamyloxy (cpd. D), 5-methyl-1,3,4-thiazol-2-ylthio (cpd. B) or 1-methyl-1,2,3,4-tetrazol-5-ylthio (cpd. A)), are broad spectrum antibiotics effective against Gram-positive and Gram-negative bacteria (partic. Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus species) and stable to bacterial beta-lactamase. The cpds. have low toxicity, are well absorbed to give high blood levels and do not show hemolytic activity.
FR7601283A 1976-01-19 1976-01-19 Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids Granted FR2338046A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7601283A FR2338046A2 (en) 1976-01-19 1976-01-19 Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7601283A FR2338046A2 (en) 1976-01-19 1976-01-19 Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids

Publications (2)

Publication Number Publication Date
FR2338046A2 true FR2338046A2 (en) 1977-08-12
FR2338046B2 FR2338046B2 (en) 1979-07-20

Family

ID=9168083

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7601283A Granted FR2338046A2 (en) 1976-01-19 1976-01-19 Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids

Country Status (1)

Country Link
FR (1) FR2338046A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7505375A (en) * 1974-05-09 1975-11-11 Toyama Chemical Co Ltd NEW PENICILLIN AND CEPHALOSPORIN DERIVATIVES AND METHOD FOR PREPARING THEM.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7505375A (en) * 1974-05-09 1975-11-11 Toyama Chemical Co Ltd NEW PENICILLIN AND CEPHALOSPORIN DERIVATIVES AND METHOD FOR PREPARING THEM.

Also Published As

Publication number Publication date
FR2338046B2 (en) 1979-07-20

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Legal Events

Date Code Title Description
CC Supplementary certificate of protection laid open to the public (law of 25 june 1990)

Free format text: 92C0487, 920625

CB Supplementary certificate of protection granted (law of 25 june 1990)

Free format text: 92C0487, 760119

CL Concession to grant licenses