IE40057L - 4- oxo -1- pyridinyl penicillin and cephalosporin¹derivatives - Google Patents
4- oxo -1- pyridinyl penicillin and cephalosporin¹derivativesInfo
- Publication number
- IE40057L IE40057L IE742084A IE208474A IE40057L IE 40057 L IE40057 L IE 40057L IE 742084 A IE742084 A IE 742084A IE 208474 A IE208474 A IE 208474A IE 40057 L IE40057 L IE 40057L
- Authority
- IE
- Ireland
- Prior art keywords
- novel
- oxo
- compounds
- utilisable
- gram
- Prior art date
Links
- -1 4- oxo -1- pyridinyl penicillin Chemical compound 0.000 title 1
- 229930182555 Penicillin Natural products 0.000 title 1
- 229940049954 penicillin Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940124587 cephalosporin Drugs 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- GCNTZFIIOFTKIY-UHFFFAOYSA-N 4-hydroxypyridine Chemical compound OC1=CC=NC=C1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 108010087702 Penicillinase Proteins 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 1
- 229950009506 penicillinase Drugs 0.000 abstract 1
- 244000144977 poultry Species 0.000 abstract 1
- 150000003952 β-lactams Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2219/00—Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
- C10M2219/10—Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2219/00—Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
- C10M2219/10—Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
- C10M2219/102—Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring containing sulfur and carbon only in the ring
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2219/00—Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
- C10M2219/10—Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
- C10M2219/104—Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring containing sulfur and carbon with nitrogen or oxygen in the ring
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2219/00—Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
- C10M2219/10—Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
- C10M2219/104—Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring containing sulfur and carbon with nitrogen or oxygen in the ring
- C10M2219/106—Thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
- C10N2040/00—Specified use or application for which the lubricating composition is intended
- C10N2040/20—Metal working
- C10N2040/22—Metal working with essential removal of material, e.g. cutting, grinding or drilling
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The preparation of novel 4-oxo-1-pyridinylpenicillin and -cephalosporin derivatives of the formula I, in which the substituents are defined in Claim 1, is described. The said compounds are prepared by converting a 4-hydroxypyridine into the corresponding silyl ether and then condensing this with an alpha -haloacetamido beta -lactam. The novel compounds are utilisable as antibacterial active compounds, since they have a high degree of efficacy against a large number of microorganisms. The novel cephalosporin derivatives are particularly utilisable against penicillinase-producing microorganisms and can therefore be used as antibacterial agents in the treatment of infectious diseases which are caused by gram-positive and gram-negative bacteria in poultry and animals, including humans.
[GB1446409A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41356573A | 1973-11-07 | 1973-11-07 | |
| US50899974A | 1974-09-27 | 1974-09-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40057L true IE40057L (en) | 1975-05-07 |
| IE40057B1 IE40057B1 (en) | 1979-02-28 |
Family
ID=27022230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2084/74A IE40057B1 (en) | 1973-11-07 | 1974-10-08 | 4-oxo-1-pyridinyl penicillin and cephalosporin derivatives |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5082088A (en) |
| CA (1) | CA1066269A (en) |
| CH (1) | CH610326A5 (en) |
| DE (1) | DE2450048A1 (en) |
| DK (1) | DK564874A (en) |
| ES (1) | ES431688A1 (en) |
| FR (1) | FR2257290B1 (en) |
| GB (1) | GB1446409A (en) |
| IE (1) | IE40057B1 (en) |
| IL (1) | IL45877A (en) |
| NL (1) | NL7414395A (en) |
| NO (1) | NO743991L (en) |
| NZ (1) | NZ175674A (en) |
| SE (1) | SE7413947L (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2507834A1 (en) * | 1975-02-24 | 1976-09-02 | Merck Patent Gmbh | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
| GB8308054D0 (en) * | 1983-03-24 | 1983-05-05 | Hider R C | Pharmaceutical compositions |
| US4912118A (en) * | 1983-09-23 | 1990-03-27 | National Research Development Corporation | Pharmaceutical compositions |
-
1974
- 1974-10-08 IE IE2084/74A patent/IE40057B1/en unknown
- 1974-10-11 NZ NZ175674A patent/NZ175674A/en unknown
- 1974-10-18 IL IL45877A patent/IL45877A/en unknown
- 1974-10-21 CA CA211,827A patent/CA1066269A/en not_active Expired
- 1974-10-22 DE DE19742450048 patent/DE2450048A1/en not_active Withdrawn
- 1974-10-30 DK DK564874A patent/DK564874A/da unknown
- 1974-11-05 NL NL7414395A patent/NL7414395A/en not_active Application Discontinuation
- 1974-11-06 GB GB4792274A patent/GB1446409A/en not_active Expired
- 1974-11-06 NO NO743991A patent/NO743991L/no unknown
- 1974-11-06 SE SE7413947A patent/SE7413947L/xx unknown
- 1974-11-06 ES ES431688A patent/ES431688A1/en not_active Expired
- 1974-11-06 CH CH1485574A patent/CH610326A5/en not_active IP Right Cessation
- 1974-11-06 FR FR7436875A patent/FR2257290B1/fr not_active Expired
- 1974-11-06 JP JP49127236A patent/JPS5082088A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL45877A0 (en) | 1974-12-31 |
| NO743991L (en) | 1975-06-02 |
| NZ175674A (en) | 1978-03-06 |
| FR2257290B1 (en) | 1977-07-01 |
| IE40057B1 (en) | 1979-02-28 |
| JPS5082088A (en) | 1975-07-03 |
| FR2257290A1 (en) | 1975-08-08 |
| CH610326A5 (en) | 1979-04-12 |
| CA1066269A (en) | 1979-11-13 |
| DK564874A (en) | 1975-07-14 |
| IL45877A (en) | 1979-09-30 |
| DE2450048A1 (en) | 1975-05-15 |
| ES431688A1 (en) | 1977-04-16 |
| SE7413947L (en) | 1975-05-09 |
| NL7414395A (en) | 1975-05-12 |
| GB1446409A (en) | 1976-08-18 |
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