JPS54103872A - Antibiotic pseudomonic acid derivative and its preparation - Google Patents
Antibiotic pseudomonic acid derivative and its preparationInfo
- Publication number
- JPS54103872A JPS54103872A JP1109478A JP1109478A JPS54103872A JP S54103872 A JPS54103872 A JP S54103872A JP 1109478 A JP1109478 A JP 1109478A JP 1109478 A JP1109478 A JP 1109478A JP S54103872 A JPS54103872 A JP S54103872A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pseudomonic acid
- acid derivative
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrane Compounds (AREA)
Abstract
NEW MATERIAL:An antibiotic pseudomonic acid derivative of formula I.
USE: Remedies for infectious diseases of men and animals by bacteria, having powerful antibacterial activity against Gram-positive bacteria, e.g. Staphylococcus aureus, Streptococcus pyogenes, or Streptococcus pneumonia, penicillin- or macrolide- resistant bacteria for a long duration. Useful as an intermediate for synthesis of other antibiotics.
PROCESS: An antibiotic pseudomonic acid of formula II is changed into the corresponding halohydrin compound by the well-known method, and reduced with a suitable reducing agent, e.g. zinc dust or phosphine to give the compound of formula I. The halohydrin compound is obtained by dissolving a compound of formula II in an organic solvent containing lithium bromide, and by adding hydrobromic acid to the solution.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1109478A JPS54103872A (en) | 1978-02-02 | 1978-02-02 | Antibiotic pseudomonic acid derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1109478A JPS54103872A (en) | 1978-02-02 | 1978-02-02 | Antibiotic pseudomonic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54103872A true JPS54103872A (en) | 1979-08-15 |
Family
ID=11768399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1109478A Pending JPS54103872A (en) | 1978-02-02 | 1978-02-02 | Antibiotic pseudomonic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54103872A (en) |
-
1978
- 1978-02-02 JP JP1109478A patent/JPS54103872A/en active Pending
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