GB1074235A - Antibiotics r-451b(x)and r-451d(x)and processes for their manufacture - Google Patents
Antibiotics r-451b(x)and r-451d(x)and processes for their manufactureInfo
- Publication number
- GB1074235A GB1074235A GB28829/64A GB2882964A GB1074235A GB 1074235 A GB1074235 A GB 1074235A GB 28829/64 A GB28829/64 A GB 28829/64A GB 2882964 A GB2882964 A GB 2882964A GB 1074235 A GB1074235 A GB 1074235A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotics
- methanol
- spectrum
- pict
- infra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
- C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
- C12P19/485—Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/29—Micromonospora
Abstract
The invention relates to the broad spectrum antibiotics R-451 B(X) and R-451 D(X) which are obtained by recrystallizing from an organic solvent the antibiotics R-451 B and R-451 D produced by cultivating micromonospora carbonacea according to Specification 1,021,402. Antibiotic R-451 B(X) has a m.pt. 154-157 DEG C., an elementary analysis C=51.02%, H=6.68%, N=1.23%, O=34.72%, Cl=3.97%, optical rotation [a ]25D= -25.5 (1% pyridine), U.V. max. absorption at 288 mm with E1% in <PICT:1074235/C2/1> <PICT:1074235/C2/2> methanol = 12 and an infra-red absorption spectrum as in Fig. 1. Antibiotic R-451 D(X) has a m.pt. 160-161 DEG C., an elementary analysis C=51.79%, H=6.35%, N=1.40%, O=36.35%, Cl=3.98%; an optical rotation [a ]25D= -25.3 DEG (1% in methanol); ultra-violet absorption maximum at 289 mm with E1% in methanol=22, and infra-red spectrum as shown in Fig. 2. R-451 D(X) methyl ether is prepared by treating R-451 D(X) with diazomethane in a solvent. R-451 D(X) acetate is prepared by treating R-451 D(X) with acetic anhydride in pyridine. The antibiotics form salts with bases, ethers (as above) and O-acyl dervatives (as above). Pharmaceutical compositions comprise one or more antibiotics identified as R-451 B(X), R-451 D(X) and R-451 D(X) acetate and a carrier. They are active against gram-positive pathogenic microorganisms in man and animals, e.g. mastitis in cattle and pleuropneumonia diseases in poultry.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15226261A | 1961-11-14 | 1961-11-14 | |
US18448462A | 1962-04-02 | 1962-04-02 | |
US19841462A | 1962-05-23 | 1962-05-23 | |
US21115462A | 1962-07-16 | 1962-07-16 | |
US211153A US3091572A (en) | 1962-07-16 | 1962-07-16 | Gentamycin and method of production |
US21180662A | 1962-07-23 | 1962-07-23 | |
US29799963A | 1963-07-24 | 1963-07-24 | |
US35416864A | 1964-03-23 | 1964-03-23 | |
US76250468A | 1968-09-25 | 1968-09-25 | |
US76912268A | 1968-10-21 | 1968-10-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1074235A true GB1074235A (en) | 1967-07-05 |
Family
ID=27581070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB28829/64A Expired GB1074235A (en) | 1961-11-14 | 1964-07-13 | Antibiotics r-451b(x)and r-451d(x)and processes for their manufacture |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE650943A (en) |
FR (1) | FR117F (en) |
GB (1) | GB1074235A (en) |
LU (1) | LU42688A1 (en) |
NL (3) | NL6408506A (en) |
OA (1) | OA00868A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1178311A1 (en) * | 1999-05-10 | 2002-02-06 | Tomoya Sato | Method and apparatus for determining the type and/or condition of disease and method and apparatus for screening drug |
-
0
- NL NL285188D patent/NL285188A/xx unknown
- FR FR117D patent/FR117F/fr active Active
-
1962
- 1962-11-13 LU LU42688D patent/LU42688A1/xx unknown
-
1964
- 1964-07-13 GB GB28829/64A patent/GB1074235A/en not_active Expired
- 1964-07-24 BE BE650943D patent/BE650943A/xx unknown
- 1964-07-24 NL NL6408506A patent/NL6408506A/xx unknown
- 1964-12-22 OA OA50956A patent/OA00868A/en unknown
-
1972
- 1972-02-10 NL NL7201760A patent/NL7201760A/xx unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1178311A1 (en) * | 1999-05-10 | 2002-02-06 | Tomoya Sato | Method and apparatus for determining the type and/or condition of disease and method and apparatus for screening drug |
EP1178311A4 (en) * | 1999-05-10 | 2003-04-09 | Tomoya Sato | Method and apparatus for determining the type and/or condition of disease and method and apparatus for screening drug |
US6743637B2 (en) | 1999-05-10 | 2004-06-01 | Tomoya Sato | Disease type and/or condition determination method and apparatus and drug screening method and apparatus |
Also Published As
Publication number | Publication date |
---|---|
BE650943A (en) | 1964-11-16 |
NL7201760A (en) | 1972-05-25 |
NL285188A (en) | |
FR117F (en) | |
OA00868A (en) | 1968-03-22 |
NL6408506A (en) | 1965-01-25 |
LU42688A1 (en) | 1963-01-13 |
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