JPS55115898A - 3",4"-diacyltylosin derivative - Google Patents

3",4"-diacyltylosin derivative

Info

Publication number
JPS55115898A
JPS55115898A JP2234079A JP2234079A JPS55115898A JP S55115898 A JPS55115898 A JP S55115898A JP 2234079 A JP2234079 A JP 2234079A JP 2234079 A JP2234079 A JP 2234079A JP S55115898 A JPS55115898 A JP S55115898A
Authority
JP
Japan
Prior art keywords
compound
alkanoyl
acetyl
methanol
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2234079A
Other languages
Japanese (ja)
Other versions
JPS6155518B2 (en
Inventor
Hideo Sakakibara
Tatsuro Fujiwara
Osamu Okegawa
Toshiyuki Watanabe
Susumu Watanabe
Tetsuo Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP2234079A priority Critical patent/JPS55115898A/en
Priority to SE7907547A priority patent/SE445739B/en
Priority to IT25677/79A priority patent/IT1123137B/en
Priority to FR7922759A priority patent/FR2436150A1/en
Priority to CH830879A priority patent/CH642381A5/en
Priority to DK382979A priority patent/DK153492C/en
Priority to CA335,557A priority patent/CA1133899A/en
Priority to HU79TO1116A priority patent/HU181976B/en
Priority to GB7931717A priority patent/GB2031418B/en
Priority to NL7906894A priority patent/NL7906894A/en
Priority to DE19792937267 priority patent/DE2937267A1/en
Priority to AT0607479A priority patent/AT366699B/en
Priority to US06/075,661 priority patent/US4268665A/en
Publication of JPS55115898A publication Critical patent/JPS55115898A/en
Priority to AT0518080A priority patent/AT367432B/en
Priority to DK446985A priority patent/DK156071C/en
Publication of JPS6155518B2 publication Critical patent/JPS6155518B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound (or its salt) of formula I (R1 is H or lower alkanoyl; one of A1 and A2 is R2 and the other is R3; R2,3 are 2W6C alkanoyl; excluding the case that R1 is H, A1 is acetyl and A2 is isovaleryl at the same time).
EXAMPLE: 3"-Acetyl-4"-butyryltylosin.
USE: Antibacterial agent useful as a remedy for infectious diseases.
PROCESS: The compound of formula IV which corresponds to the compound I wherein R1 is H, is prepared, e.g. by (1) reacting a (4'''-position OH-group-protected) tylosin with an aliphatic carboxylic acid anhydride in the presence of an inorganic base, (2) heating and reacting the resulting compound II [R4 is lower (halo)alkanoyl] with an aliphatic carboxylic acid anhydride in an inert organic solvent in the presence of an organic tertamine, (3) treating the resulting compound III with ammonia in methanol, and (4) heating the product in methanol.
COPYRIGHT: (C)1980,JPO&Japio
JP2234079A 1978-09-14 1979-02-27 3",4"-diacyltylosin derivative Granted JPS55115898A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP2234079A JPS55115898A (en) 1979-02-27 1979-02-27 3",4"-diacyltylosin derivative
SE7907547A SE445739B (en) 1978-09-14 1979-09-11 3 ", 4" DIACYLTYLOSINE DERIVATIVE
IT25677/79A IT1123137B (en) 1978-09-14 1979-09-12 "3", 4 "-DIACYLTYLOSINE AND PROCEDURE FOR ITS PRODUCTION
FR7922759A FR2436150A1 (en) 1978-09-14 1979-09-12 3 '', 4 '' DERIVATIVES - DIACYLTYLOSINE USEFUL AS MEDICINES
HU79TO1116A HU181976B (en) 1978-09-14 1979-09-13 Process for preparing 3",4"-diacyl-tylosin derivatives
DK382979A DK153492C (en) 1978-09-14 1979-09-13 PROCEDURE FOR PREPARING 3AE, 4AE-DIACYLTYLOSIN DERIVATIVES
CA335,557A CA1133899A (en) 1978-09-14 1979-09-13 3", 4"-diacyltylosin derivatives
CH830879A CH642381A5 (en) 1978-09-14 1979-09-13 DIALKANOYLTYLOSIN DERIVATIVES.
GB7931717A GB2031418B (en) 1978-09-14 1979-09-13 3'',4''-diacyl derivatives of tylosin
AT0607479A AT366699B (en) 1978-09-14 1979-09-14 METHOD FOR PRODUCING 3 '', 4 '' DIACYLTYLOSIN DERIVATIVES
DE19792937267 DE2937267A1 (en) 1978-09-14 1979-09-14 3 '', 4 '' DIACYLTYLOSIN DERIVATIVES
NL7906894A NL7906894A (en) 1978-09-14 1979-09-14 3 ", 4" DIACYLTYLOSINE DERIVATIVES.
US06/075,661 US4268665A (en) 1978-09-14 1979-09-14 Derivatives of antibiotic tylosin
AT0518080A AT367432B (en) 1978-09-14 1980-10-20 METHOD FOR PRODUCING NEW 3 ", 4" DIACYLTYLOSIN DERIVATIVES
DK446985A DK156071C (en) 1978-09-14 1985-10-02 PROCEDURE FOR PREPARING 3,3 '', 4 '' - TRIACYLTYLOSIN DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2234079A JPS55115898A (en) 1979-02-27 1979-02-27 3",4"-diacyltylosin derivative

Publications (2)

Publication Number Publication Date
JPS55115898A true JPS55115898A (en) 1980-09-06
JPS6155518B2 JPS6155518B2 (en) 1986-11-28

Family

ID=12079958

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2234079A Granted JPS55115898A (en) 1978-09-14 1979-02-27 3",4"-diacyltylosin derivative

Country Status (1)

Country Link
JP (1) JPS55115898A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6028984A (en) * 1983-07-26 1985-02-14 Kyowa Hakko Kogyo Co Ltd 3",4"-di-o-acylspiramycin i
JPS60126296A (en) * 1983-12-13 1985-07-05 Kyowa Hakko Kogyo Co Ltd 3,3",4"-tri-o-acylspiramycin i

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6028984A (en) * 1983-07-26 1985-02-14 Kyowa Hakko Kogyo Co Ltd 3",4"-di-o-acylspiramycin i
JPS60126296A (en) * 1983-12-13 1985-07-05 Kyowa Hakko Kogyo Co Ltd 3,3",4"-tri-o-acylspiramycin i

Also Published As

Publication number Publication date
JPS6155518B2 (en) 1986-11-28

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