JPS55115898A - 3",4"-diacyltylosin derivative - Google Patents
3",4"-diacyltylosin derivativeInfo
- Publication number
- JPS55115898A JPS55115898A JP2234079A JP2234079A JPS55115898A JP S55115898 A JPS55115898 A JP S55115898A JP 2234079 A JP2234079 A JP 2234079A JP 2234079 A JP2234079 A JP 2234079A JP S55115898 A JPS55115898 A JP S55115898A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkanoyl
- acetyl
- methanol
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound (or its salt) of formula I (R1 is H or lower alkanoyl; one of A1 and A2 is R2 and the other is R3; R2,3 are 2W6C alkanoyl; excluding the case that R1 is H, A1 is acetyl and A2 is isovaleryl at the same time).
EXAMPLE: 3"-Acetyl-4"-butyryltylosin.
USE: Antibacterial agent useful as a remedy for infectious diseases.
PROCESS: The compound of formula IV which corresponds to the compound I wherein R1 is H, is prepared, e.g. by (1) reacting a (4'''-position OH-group-protected) tylosin with an aliphatic carboxylic acid anhydride in the presence of an inorganic base, (2) heating and reacting the resulting compound II [R4 is lower (halo)alkanoyl] with an aliphatic carboxylic acid anhydride in an inert organic solvent in the presence of an organic tertamine, (3) treating the resulting compound III with ammonia in methanol, and (4) heating the product in methanol.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2234079A JPS55115898A (en) | 1979-02-27 | 1979-02-27 | 3",4"-diacyltylosin derivative |
SE7907547A SE445739B (en) | 1978-09-14 | 1979-09-11 | 3 ", 4" DIACYLTYLOSINE DERIVATIVE |
IT25677/79A IT1123137B (en) | 1978-09-14 | 1979-09-12 | "3", 4 "-DIACYLTYLOSINE AND PROCEDURE FOR ITS PRODUCTION |
FR7922759A FR2436150A1 (en) | 1978-09-14 | 1979-09-12 | 3 '', 4 '' DERIVATIVES - DIACYLTYLOSINE USEFUL AS MEDICINES |
HU79TO1116A HU181976B (en) | 1978-09-14 | 1979-09-13 | Process for preparing 3",4"-diacyl-tylosin derivatives |
DK382979A DK153492C (en) | 1978-09-14 | 1979-09-13 | PROCEDURE FOR PREPARING 3AE, 4AE-DIACYLTYLOSIN DERIVATIVES |
CA335,557A CA1133899A (en) | 1978-09-14 | 1979-09-13 | 3", 4"-diacyltylosin derivatives |
CH830879A CH642381A5 (en) | 1978-09-14 | 1979-09-13 | DIALKANOYLTYLOSIN DERIVATIVES. |
GB7931717A GB2031418B (en) | 1978-09-14 | 1979-09-13 | 3'',4''-diacyl derivatives of tylosin |
AT0607479A AT366699B (en) | 1978-09-14 | 1979-09-14 | METHOD FOR PRODUCING 3 '', 4 '' DIACYLTYLOSIN DERIVATIVES |
DE19792937267 DE2937267A1 (en) | 1978-09-14 | 1979-09-14 | 3 '', 4 '' DIACYLTYLOSIN DERIVATIVES |
NL7906894A NL7906894A (en) | 1978-09-14 | 1979-09-14 | 3 ", 4" DIACYLTYLOSINE DERIVATIVES. |
US06/075,661 US4268665A (en) | 1978-09-14 | 1979-09-14 | Derivatives of antibiotic tylosin |
AT0518080A AT367432B (en) | 1978-09-14 | 1980-10-20 | METHOD FOR PRODUCING NEW 3 ", 4" DIACYLTYLOSIN DERIVATIVES |
DK446985A DK156071C (en) | 1978-09-14 | 1985-10-02 | PROCEDURE FOR PREPARING 3,3 '', 4 '' - TRIACYLTYLOSIN DERIVATIVES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2234079A JPS55115898A (en) | 1979-02-27 | 1979-02-27 | 3",4"-diacyltylosin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55115898A true JPS55115898A (en) | 1980-09-06 |
JPS6155518B2 JPS6155518B2 (en) | 1986-11-28 |
Family
ID=12079958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2234079A Granted JPS55115898A (en) | 1978-09-14 | 1979-02-27 | 3",4"-diacyltylosin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55115898A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6028984A (en) * | 1983-07-26 | 1985-02-14 | Kyowa Hakko Kogyo Co Ltd | 3",4"-di-o-acylspiramycin i |
JPS60126296A (en) * | 1983-12-13 | 1985-07-05 | Kyowa Hakko Kogyo Co Ltd | 3,3",4"-tri-o-acylspiramycin i |
-
1979
- 1979-02-27 JP JP2234079A patent/JPS55115898A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6028984A (en) * | 1983-07-26 | 1985-02-14 | Kyowa Hakko Kogyo Co Ltd | 3",4"-di-o-acylspiramycin i |
JPS60126296A (en) * | 1983-12-13 | 1985-07-05 | Kyowa Hakko Kogyo Co Ltd | 3,3",4"-tri-o-acylspiramycin i |
Also Published As
Publication number | Publication date |
---|---|
JPS6155518B2 (en) | 1986-11-28 |
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