JPS575000A - Tylosin derivative - Google Patents
Tylosin derivativeInfo
- Publication number
- JPS575000A JPS575000A JP7943780A JP7943780A JPS575000A JP S575000 A JPS575000 A JP S575000A JP 7943780 A JP7943780 A JP 7943780A JP 7943780 A JP7943780 A JP 7943780A JP S575000 A JPS575000 A JP S575000A
- Authority
- JP
- Japan
- Prior art keywords
- alkanoyloxy
- formula
- substituted
- compound shown
- tylosin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A tylosin derivative shown by the formula I [R1 is alkanoyloxy, (substituted)aromatic acyloxy, tetrahydropyranyloxy, (substituted)benzenesulfonyloxy, etc.; R2 is OH, alkanoyloxy, (substituted) aromatic acyloxy, etc.].
EXAMPLE: 3,23-Di-O-acetyl mycaminosyl tylonolide.
USE: An antibacterial agent. Having structural characteristics on the point that the titled substance has the substituent groups of R1 and R2 at 23 and 3 positions of mycaminosyl tylonolide. Having more improved antibacterial activity on Gram- negative and Gram-positive Bacteria than tylosin.
PROCESS: A compound shown by the formula II [R3 is (protected) aldehyde; R4 is (protected) hydroxyl group] is acylated, and converted into a tetrahydropyranyl compound, etc., to give a compound shown by the formula III (R1' is alkanoyloxy, etc.; R2' is OH, alkanoyloxy, etc.) and the protecting group is removed, to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7943780A JPS575000A (en) | 1980-06-12 | 1980-06-12 | Tylosin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7943780A JPS575000A (en) | 1980-06-12 | 1980-06-12 | Tylosin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS575000A true JPS575000A (en) | 1982-01-11 |
JPS632275B2 JPS632275B2 (en) | 1988-01-18 |
Family
ID=13689850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7943780A Granted JPS575000A (en) | 1980-06-12 | 1980-06-12 | Tylosin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS575000A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5933298A (en) * | 1982-08-19 | 1984-02-23 | Microbial Chem Res Found | Tylosin derivative |
DE3444006A1 (en) * | 1983-11-30 | 1985-06-05 | Toyo Jozo K.K., Tagata, Shizuoka | 14-DE (HYDROXYMETHYL) -MYCAMINOSYLTYLONOLIDE DERIVATIVES |
WO1988008426A1 (en) * | 1987-04-29 | 1988-11-03 | Schering Corporation | 3-o-glycosyl 16-membered macrolide antibacterials and related derivatives |
US4962146A (en) * | 1987-04-29 | 1990-10-09 | Schering Corporation | 3-O-glycosyl 16-membered macrolide antibacterials and related derivatives |
JP5129485B2 (en) * | 2005-01-24 | 2013-01-30 | 公益財団法人微生物化学研究会 | Anti-penicillin-resistant pneumococcal agent and novel 16-membered ring macrolide derivative |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0828094B2 (en) * | 1987-07-31 | 1996-03-21 | 日立マクセル株式会社 | Tape car ledge |
-
1980
- 1980-06-12 JP JP7943780A patent/JPS575000A/en active Granted
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5933298A (en) * | 1982-08-19 | 1984-02-23 | Microbial Chem Res Found | Tylosin derivative |
JPH039918B2 (en) * | 1982-08-19 | 1991-02-12 | Microbial Chem Res Found | |
DE3444006A1 (en) * | 1983-11-30 | 1985-06-05 | Toyo Jozo K.K., Tagata, Shizuoka | 14-DE (HYDROXYMETHYL) -MYCAMINOSYLTYLONOLIDE DERIVATIVES |
US4579940A (en) * | 1983-11-30 | 1986-04-01 | Toyo Jozo Kabushiki Kaisha | 14-de(hydroxymethyl)-mycaminosyltylonolide derivatives |
WO1988008426A1 (en) * | 1987-04-29 | 1988-11-03 | Schering Corporation | 3-o-glycosyl 16-membered macrolide antibacterials and related derivatives |
US4962146A (en) * | 1987-04-29 | 1990-10-09 | Schering Corporation | 3-O-glycosyl 16-membered macrolide antibacterials and related derivatives |
JP5129485B2 (en) * | 2005-01-24 | 2013-01-30 | 公益財団法人微生物化学研究会 | Anti-penicillin-resistant pneumococcal agent and novel 16-membered ring macrolide derivative |
US8507453B2 (en) | 2005-01-24 | 2013-08-13 | Microbial Chemistry Research Foundation | Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative |
Also Published As
Publication number | Publication date |
---|---|
JPS632275B2 (en) | 1988-01-18 |
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