JPS5742698A - Novel derivative of tylosin - Google Patents

Novel derivative of tylosin

Info

Publication number
JPS5742698A
JPS5742698A JP55118915A JP11891580A JPS5742698A JP S5742698 A JPS5742698 A JP S5742698A JP 55118915 A JP55118915 A JP 55118915A JP 11891580 A JP11891580 A JP 11891580A JP S5742698 A JPS5742698 A JP S5742698A
Authority
JP
Japan
Prior art keywords
formula
compound
tylosin
alkanoyloxy
dotted line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55118915A
Other languages
Japanese (ja)
Inventor
Akihiro Tanaka
Osamu Tsuchiya
Sumio Umezawa
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP55118915A priority Critical patent/JPS5742698A/en
Priority to US06/285,747 priority patent/US4438109A/en
Priority to DE19813129112 priority patent/DE3129112A1/en
Priority to GB8122796A priority patent/GB2081711B/en
Priority to CA000382401A priority patent/CA1202621A/en
Priority to ES504282A priority patent/ES504282A0/en
Priority to CH4830/81A priority patent/CH650513A5/en
Priority to FR8114456A priority patent/FR2495620A1/en
Publication of JPS5742698A publication Critical patent/JPS5742698A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The tylosin derivative of formula I [R1 is H, OH, or alkanoyloxy; R2 is OH or alkanoyloxy; the dotted line is single bond or double bond (when R1 is H, the dotted line is double bond)].
EXAMPLE: 3,4"-Di-O-acetyl-4'-deoxydemycarosyl tylosin.
USE: Antibacterial agent and its intermediate.
PROCESS: The demycarosyl tylosin of formula II having protected aldehyde group at the 20-position is made to react with the (substituted) benzylsulfonic acid (or its reactive derivative) to convert the 4'-position to sulfonic acid ester. The resulted compound of formula III is treated with an alkali metal halide to obtain the compound of formula IV wherein the 4'-position is converted to a halogen-substituent. The compound is reacted with tri-substituted tin halide to obtain the deoxy compound of formula V, which is convertd to the objective compound of formula I by removing the protecting group from the aldehyde group, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP55118915A 1980-07-25 1980-08-28 Novel derivative of tylosin Pending JPS5742698A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP55118915A JPS5742698A (en) 1980-08-28 1980-08-28 Novel derivative of tylosin
US06/285,747 US4438109A (en) 1980-07-25 1981-07-22 Tylosin derivatives
DE19813129112 DE3129112A1 (en) 1980-07-25 1981-07-23 TYLOSIN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
GB8122796A GB2081711B (en) 1980-07-25 1981-07-23 Tylosin derivatives
CA000382401A CA1202621A (en) 1980-07-25 1981-07-23 Process for producing tylosin derivatives
ES504282A ES504282A0 (en) 1980-07-25 1981-07-24 A PROCEDURE FOR THE PRODUCTION OF A TILOSINE DERIVATIVE
CH4830/81A CH650513A5 (en) 1980-07-25 1981-07-24 TYLOSIN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF.
FR8114456A FR2495620A1 (en) 1980-07-25 1981-07-24 DERIVATIVES OF TYLOSINE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55118915A JPS5742698A (en) 1980-08-28 1980-08-28 Novel derivative of tylosin

Publications (1)

Publication Number Publication Date
JPS5742698A true JPS5742698A (en) 1982-03-10

Family

ID=14748317

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55118915A Pending JPS5742698A (en) 1980-07-25 1980-08-28 Novel derivative of tylosin

Country Status (1)

Country Link
JP (1) JPS5742698A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541303A (en) * 1992-01-14 1996-07-30 Zaidan Hojin Biseibutsu Kagaku Kenkyukai 3,4'-dideoxymycaminosltylonolide derivative and process for producing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541303A (en) * 1992-01-14 1996-07-30 Zaidan Hojin Biseibutsu Kagaku Kenkyukai 3,4'-dideoxymycaminosltylonolide derivative and process for producing the same

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