JPS54103871A - Pseudomonic acid derivative and its preparation - Google Patents
Pseudomonic acid derivative and its preparationInfo
- Publication number
- JPS54103871A JPS54103871A JP864878A JP864878A JPS54103871A JP S54103871 A JPS54103871 A JP S54103871A JP 864878 A JP864878 A JP 864878A JP 864878 A JP864878 A JP 864878A JP S54103871 A JPS54103871 A JP S54103871A
- Authority
- JP
- Japan
- Prior art keywords
- pseudomonic acid
- formula
- salt
- bacteria
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A pseudomonic acid derivative of formula I: (R is H, 1-6C alkyl, or aryl group; X is O or S). EXAMPLE:1-Pseudomonic acid 4-phenyl-thiosemicarbazide. USE:Remedies for infectious diseases of men and animals by bacteria, having powerful antibacterial ability against Gram-positive bacteria, such as Staphylococcus aureus, Streptococcus pyogenes or Streptococcus pneumoniae, effective against penicillin- or macrolide-resistant bacteria. PROCESS:An inorganic salt (sodium salt) or organic salt (triethylamine salt) of pseudomonic acid is reacted with a monoalkyl carbonate, e.g. ethyl carbonate, or an organic halide, e.g. isovaleryl chloride, to form a mixed acid anhydride, which is reacted with a compound of formula II to give the compound of formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP864878A JPS54103871A (en) | 1978-01-28 | 1978-01-28 | Pseudomonic acid derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP864878A JPS54103871A (en) | 1978-01-28 | 1978-01-28 | Pseudomonic acid derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54103871A true JPS54103871A (en) | 1979-08-15 |
JPS6157312B2 JPS6157312B2 (en) | 1986-12-06 |
Family
ID=11698754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP864878A Granted JPS54103871A (en) | 1978-01-28 | 1978-01-28 | Pseudomonic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54103871A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292892A (en) * | 1991-05-07 | 1994-03-08 | Sankyo Company, Limited | Anti-bacterial compound and pharmaceutical compositions thereof |
US5380723A (en) * | 1991-10-07 | 1995-01-10 | Nisshin Flour Milling Co., Ltd. | Indole derivatives |
US5399711A (en) * | 1992-09-18 | 1995-03-21 | Sankyo Company, Limited | Thiomarinol compounds |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61236028A (en) * | 1985-04-10 | 1986-10-21 | Csk Corp | Optical recording medium |
JPS61236029A (en) * | 1985-04-10 | 1986-10-21 | Csk Corp | Optical recording medium |
JPH0250282A (en) * | 1988-08-12 | 1990-02-20 | Casio Comput Co Ltd | Data reading device |
-
1978
- 1978-01-28 JP JP864878A patent/JPS54103871A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292892A (en) * | 1991-05-07 | 1994-03-08 | Sankyo Company, Limited | Anti-bacterial compound and pharmaceutical compositions thereof |
US5405762A (en) * | 1991-05-07 | 1995-04-11 | Sankyo Company, Limited | Culture of alteromonas and process of using the same to produce an antibacterial compound |
US5380723A (en) * | 1991-10-07 | 1995-01-10 | Nisshin Flour Milling Co., Ltd. | Indole derivatives |
US5399711A (en) * | 1992-09-18 | 1995-03-21 | Sankyo Company, Limited | Thiomarinol compounds |
Also Published As
Publication number | Publication date |
---|---|
JPS6157312B2 (en) | 1986-12-06 |
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