GB1474790A - 7-substituted-1-cyclohexemyl and 1,4-cyclohexadiemyl-acetamido- 3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids - Google Patents

7-substituted-1-cyclohexemyl and 1,4-cyclohexadiemyl-acetamido- 3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

Info

Publication number
GB1474790A
GB1474790A GB3825074A GB3825074A GB1474790A GB 1474790 A GB1474790 A GB 1474790A GB 3825074 A GB3825074 A GB 3825074A GB 3825074 A GB3825074 A GB 3825074A GB 1474790 A GB1474790 A GB 1474790A
Authority
GB
United Kingdom
Prior art keywords
substituted
cyclohexemyl
cyclohexadiemyl
cephem
acetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3825074A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US394367A external-priority patent/US3907786A/en
Priority claimed from US05/411,559 external-priority patent/US3946000A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB1474790A publication Critical patent/GB1474790A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Compounds of the formula I <IMAGE> in which R denotes various heterocyclic radicals as defined in claim 1, are prepared by reacting a correspondingly substituted 7-aminocephemcarboxylic acid derivative with an appropriate cyclohexa(di)enylacetic acid. The novel compounds have valuable antibacterial effects for treating humans, mammals and poultry, especially for treating infectious diseases caused by various Gram-positive and Gram-negative bacteria.
GB3825074A 1973-09-04 1974-09-02 7-substituted-1-cyclohexemyl and 1,4-cyclohexadiemyl-acetamido- 3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids Expired GB1474790A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US394367A US3907786A (en) 1973-09-04 1973-09-04 7-{8 {60 -(2-aminomethyl-1,4-cyclohexadienyl)acetamido{9 -3-heterocyclic-thiomethyl-3-cephem-4-carboxylic acids and salts
US05/411,559 US3946000A (en) 1973-10-31 1973-10-31 7-[α-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

Publications (1)

Publication Number Publication Date
GB1474790A true GB1474790A (en) 1977-05-25

Family

ID=27014711

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3825074A Expired GB1474790A (en) 1973-09-04 1974-09-02 7-substituted-1-cyclohexemyl and 1,4-cyclohexadiemyl-acetamido- 3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

Country Status (13)

Country Link
JP (1) JPS5924158B2 (en)
CA (1) CA1037467A (en)
CH (1) CH613458A5 (en)
DE (1) DE2442302C2 (en)
DK (1) DK143941C (en)
FI (1) FI60019C (en)
FR (1) FR2242103B1 (en)
GB (1) GB1474790A (en)
HU (1) HU169170B (en)
IE (1) IE39830B1 (en)
NL (1) NL7411569A (en)
SE (1) SE423714B (en)
YU (1) YU233874A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112645883A (en) * 2020-12-23 2021-04-13 扬州天和药业有限公司 Preparation method of 3, 6-dichloropyridazine

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002316862A1 (en) * 2001-04-19 2002-11-05 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporin derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112645883A (en) * 2020-12-23 2021-04-13 扬州天和药业有限公司 Preparation method of 3, 6-dichloropyridazine

Also Published As

Publication number Publication date
DE2442302A1 (en) 1975-03-06
CA1037467A (en) 1978-08-29
SE423714B (en) 1982-05-24
CH613458A5 (en) 1979-09-28
YU233874A (en) 1982-06-30
DK143941B (en) 1981-11-02
HU169170B (en) 1976-10-28
IE39830B1 (en) 1979-01-03
FI60019B (en) 1981-07-31
AU7291474A (en) 1976-03-11
JPS5058089A (en) 1975-05-20
FR2242103A1 (en) 1975-03-28
JPS5924158B2 (en) 1984-06-07
DE2442302C2 (en) 1982-11-18
DK143941C (en) 1982-04-13
FR2242103B1 (en) 1978-07-21
FI256074A (en) 1975-03-05
NL7411569A (en) 1975-03-06
FI60019C (en) 1981-11-10
DK466574A (en) 1975-05-05
IE39830L (en) 1975-03-04
SE7411146L (en) 1975-03-05

Similar Documents

Publication Publication Date Title
ES8104233A1 (en) Quinoline carboxylic acid derivatives
MY102919A (en) Pleuromutilin derivatives process for their preparation and their use.
FI864825A (en) CEFALOSPORINDERIVAT.
SE7709002L (en) UNSATATED DERIVATIVES OF 7-ACYLAMIDO-3-CEFEM-4-CARBOXYLIC ACID AND METHODS OF PREPARING THE SAME
ES426003A1 (en) {60 -amino-{60 -(ureidophenyl)acetamidocephalosporins
JPS5543011A (en) 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
GB1460377A (en) Antibacterial guanylhydrazones
GB1474790A (en) 7-substituted-1-cyclohexemyl and 1,4-cyclohexadiemyl-acetamido- 3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids
JPS5517386A (en) Novel oxadiazolopyrimidine derivative
JPS57203087A (en) Production of antibacterial
DE3170503D1 (en) 3-0-demethyl derivatives of istamycin b series compounds and their preparation
SE7709071L (en) OLIVANIC ACID ESTERS
SE7612295L (en) ANTIBIOTIC
SE7612961L (en) TIENAMYCIN DERIVATIVES
JPS54103871A (en) Pseudomonic acid derivative and its preparation
SE8008540L (en) N-SUBSTITUTED TIAZOLYL DERIVATIVES OF OXI-IMINO SUBSTITUTED CEPHALOSPORINES AND PROCEDURES FOR PREPARING THEREOF
GB1533413A (en) Penicillins
DK206888D0 (en) THIADIAZOLYLACETAMIDCEPHEM DERIVATIVE
ES399014A1 (en) (r)-1-(2-furoyloxy)-3-methylbutyl-pencillin compounds
HU171232B (en) Process for producing 7-square bracket-bracketo 2-aminomethyl-phenyl-bracket closed-acetamido-square bracket closed-3-thiadiazolyl-thiomethyl-ceph-3-eme-4-carboxylic acid derivatives
SE7610989L (en) ANTIBACTERIAL AGENTS
IE40057L (en) 4- oxo -1- pyridinyl penicillin and cephalosporin¹derivatives
SE7501155L (en)
GB1539053A (en) Process for the preparation of alpha-(2-oxoimidazolidinyl carbonylamino)-acetamido cephalosporins
ES8407494A1 (en) Manufacture of cefuroxime and novel intermediate therefor

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee