IE39830B1 - 7-(substituted 1-cyclohexenyl and 1,4 cyclohexadienyl-acetamido)-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids - Google Patents

7-(substituted 1-cyclohexenyl and 1,4 cyclohexadienyl-acetamido)-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

Info

Publication number
IE39830B1
IE39830B1 IE1822/74A IE182274A IE39830B1 IE 39830 B1 IE39830 B1 IE 39830B1 IE 1822/74 A IE1822/74 A IE 1822/74A IE 182274 A IE182274 A IE 182274A IE 39830 B1 IE39830 B1 IE 39830B1
Authority
IE
Ireland
Prior art keywords
substituted
cephem
cyclohexadienyl
acetamido
cyclohexenyl
Prior art date
Application number
IE1822/74A
Other versions
IE39830L (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US394367A external-priority patent/US3907786A/en
Priority claimed from US05/411,559 external-priority patent/US3946000A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE39830L publication Critical patent/IE39830L/en
Publication of IE39830B1 publication Critical patent/IE39830B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compounds of the formula I <IMAGE> in which R denotes various heterocyclic radicals as defined in claim 1, are prepared by reacting a correspondingly substituted 7-aminocephemcarboxylic acid derivative with an appropriate cyclohexa(di)enylacetic acid. The novel compounds have valuable antibacterial effects for treating humans, mammals and poultry, especially for treating infectious diseases caused by various Gram-positive and Gram-negative bacteria. [GB1474790A]
IE1822/74A 1973-09-04 1974-09-03 7-(substituted 1-cyclohexenyl and 1,4 cyclohexadienyl-acetamido)-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids IE39830B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US394367A US3907786A (en) 1973-09-04 1973-09-04 7-{8 {60 -(2-aminomethyl-1,4-cyclohexadienyl)acetamido{9 -3-heterocyclic-thiomethyl-3-cephem-4-carboxylic acids and salts
US05/411,559 US3946000A (en) 1973-10-31 1973-10-31 7-[α-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

Publications (2)

Publication Number Publication Date
IE39830L IE39830L (en) 1975-03-04
IE39830B1 true IE39830B1 (en) 1979-01-03

Family

ID=27014711

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1822/74A IE39830B1 (en) 1973-09-04 1974-09-03 7-(substituted 1-cyclohexenyl and 1,4 cyclohexadienyl-acetamido)-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

Country Status (13)

Country Link
JP (1) JPS5924158B2 (en)
CA (1) CA1037467A (en)
CH (1) CH613458A5 (en)
DE (1) DE2442302C2 (en)
DK (1) DK143941C (en)
FI (1) FI60019C (en)
FR (1) FR2242103B1 (en)
GB (1) GB1474790A (en)
HU (1) HU169170B (en)
IE (1) IE39830B1 (en)
NL (1) NL7411569A (en)
SE (1) SE423714B (en)
YU (1) YU233874A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002316862A1 (en) * 2001-04-19 2002-11-05 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporin derivatives
CN112645883B (en) * 2020-12-23 2022-10-25 天和药业股份有限公司 Preparation method of 3,6-dichloropyridazine

Also Published As

Publication number Publication date
DE2442302A1 (en) 1975-03-06
CA1037467A (en) 1978-08-29
SE423714B (en) 1982-05-24
CH613458A5 (en) 1979-09-28
YU233874A (en) 1982-06-30
DK143941B (en) 1981-11-02
HU169170B (en) 1976-10-28
FI60019B (en) 1981-07-31
AU7291474A (en) 1976-03-11
JPS5058089A (en) 1975-05-20
FR2242103A1 (en) 1975-03-28
JPS5924158B2 (en) 1984-06-07
DE2442302C2 (en) 1982-11-18
DK143941C (en) 1982-04-13
FR2242103B1 (en) 1978-07-21
FI256074A (en) 1975-03-05
NL7411569A (en) 1975-03-06
FI60019C (en) 1981-11-10
DK466574A (en) 1975-05-05
IE39830L (en) 1975-03-04
SE7411146L (en) 1975-03-05
GB1474790A (en) 1977-05-25

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